HSP
Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.
Trovati 179 prodotti di "HSP"
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MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Formula:C54H66N4O10Colore e forma:SolidPeso molecolare:931.12dPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Colore e forma:Odour SolidGrp94 Inhibitor-3
Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.Formula:C24H20ClNO4Colore e forma:SolidPeso molecolare:421.87Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Formula:C34H49F3N4O10Colore e forma:SolidPeso molecolare:730.34008Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formula:C24H18F3N5O3Colore e forma:SolidPeso molecolare:481.43NPX800
CAS:NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Formula:C32H32FN5O4Purezza:99.29%Colore e forma:SolidPeso molecolare:569.63Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Formula:C31H30N6O6S4Purezza:98%Colore e forma:Off-White To Fawn SolidPeso molecolare:710.87CCT245232
CAS:CCT245232 is a potent HSF1 inhibitor, possibly used for researching cancer.Formula:C27H23N3O4Colore e forma:SolidPeso molecolare:453.49Palmitic acid-1-13C
CAS:Palmitic acid-13C, a 16-C saturated fatty acid internal standard for GC/LC-MS, is prevalent in plasma lipids and influences protein acylation and COX-2 levels.Formula:C16H32O2Colore e forma:SolidPeso molecolare:257.422PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Formula:C18H21IN6O2SPurezza:98.31% - 99.937%Colore e forma:SolidPeso molecolare:512.37Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formula:C22H30N6O2SPurezza:98.98%Colore e forma:SolidPeso molecolare:442.58L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Formula:C8H15N3O4Purezza:99.71% - 99.97%Colore e forma:SolidPeso molecolare:217.22YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Formula:C21H19ClN2O4Purezza:97.25%Colore e forma:SolidPeso molecolare:398.84MitoBloCK-10
CAS:MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.Formula:C12H8FN3O3SPurezza:99.51%Colore e forma:SolidPeso molecolare:293.27MK2-IN-1 hydrochloride
CAS:MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.Formula:C27H26Cl2N4O2Purezza:97.32%Colore e forma:SolidPeso molecolare:509.43HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formula:C21H19N3O2S2Purezza:98.89%Colore e forma:SolidPeso molecolare:409.52Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Formula:C20H19NO4Purezza:93.77%Colore e forma:SolidPeso molecolare:337.37PF04929113
CAS:PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.Formula:C25H30F3N5O4Purezza:99.04%Colore e forma:SolidPeso molecolare:521.53XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Formula:C29H37N5O3Purezza:99.18%Colore e forma:SolidPeso molecolare:503.64PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Formula:C26H34F3N5O7SPurezza:99% - 99.46%Colore e forma:SolidPeso molecolare:617.63
