HSP

Gli inibitori delle proteine da shock termico (HSP) prendono di mira le HSP, una famiglia di chaperoni molecolari che assistono nel ripiegamento delle proteine, nella stabilità e nella protezione contro i danni indotti dallo stress. Le HSP sono spesso sovraregolate nelle cellule tumorali, aiutandole a sopravvivere in condizioni stressanti come l'ipossia e la chemioterapia. L'inibizione delle HSP può interrompere questi meccanismi protettivi, portando alla morte cellulare. Gli inibitori delle HSP sono quindi preziosi nella terapia del cancro e nella ricerca sulle risposte allo stress. Presso CymitQuimica, offriamo una gamma completa di inibitori delle HSP di alta qualità per supportare la tua ricerca nell'omeostasi delle proteine, nelle risposte allo stress e nell'oncologia.

Trovati 179 prodotti di "HSP"

Purezza (%)

100

prodotti per pagina.

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Vibsanin A
CAS:
- 72506-14-0
Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.
Formula:C₂₅H₃₈O₄
Colore e forma:Solid
Peso molecolare:402.57
Ref: TM-T68802
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6BrCaQ
CAS:
- 954416-67-2
6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.
Formula:C₁₈H₁₅BrN₂O₃
Colore e forma:Solid
Peso molecolare:387.23
Ref: TM-T61726
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Malonganenone A
CAS:
- 882403-69-2
Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.
Formula:C₂₆H₃₈N₄O₂
Colore e forma:Solid
Peso molecolare:438.61
Ref: TM-T24429
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Displurigen
CAS:
- 96156-26-2
Displurigen is an inhibitor of ATPase activity of HSP70.
Formula:C₁₅H₁₀O₄S
Purezza:98%
Colore e forma:Solid
Peso molecolare:286.3
Ref: TM-T27184
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MPC-3100
CAS:
- 958025-66-6
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].
Formula:C₂₂H₂₅BrN₆O₄S
Colore e forma:Solid
Peso molecolare:549.44
Ref: TM-T21600
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Hsp90-IN-17
CAS:
- 1253584-78-9
Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.
Formula:C₂₁H₂₀N₄O₇
Colore e forma:Solid
Peso molecolare:440.41
Ref: TM-T72996
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YM-01 Tosylate
CAS:
- 1427450-47-2
YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.
Formula:C₂₇H₂₇N₃O₄S₃
Colore e forma:Solid
Peso molecolare:553.72
Ref: TM-T29179
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Icapamespib HCl
CAS:
- 2267287-26-1
Icapamespib (PU-HZ151) is an HSP90 inhibitor; EC50 of 5 nM, logD of 2.37; targets epichaperomes, effective in cells, mice, and humans.
Formula:C₁₉H₂₅Cl₂IN₆O₂S
Colore e forma:Solid
Peso molecolare:599.31
Ref: TM-T69712
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CH5015765
CAS:
- 959766-47-3
CH5015765: potent, selective HSP90 inhibitor with high affinity and antitumor effects in human cancer mouse models.
Formula:C₁₆H₁₃ClN₄OS
Colore e forma:Solid
Peso molecolare:344.82
Ref: TM-T68228
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HSP90-IN-12
CAS:
- 2408643-60-5
VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.
Formula:C₂₅H₃₆O₄
Colore e forma:Solid
Peso molecolare:400.55
Ref: TM-T61938
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Grp94-IN-2
CAS:
- 1887032-92-9
Grp94-IN-2 is a inhibitor of Grp94.
Formula:C₂₂H₂₃ClN₂O₅
Colore e forma:Solid
Peso molecolare:430.88
Ref: TM-T70088
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YM-1
CAS:
- 409086-68-6
YM-1, a stable MKT-077 analog, inhibits Hsp70 orally, kills HeLa cells, and boosts p53 and p21 proteins.
Formula:C₂₀H₂₀ClN₃OS₂
Colore e forma:Solid
Peso molecolare:417.98
Ref: TM-T73579
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BF844
CAS:
- 1404506-35-9
BF844 chemical counters USH3-induced hearing loss by transporting mutated CLRN1 to cell membranes, effectively preserving hearing in vivo.
Formula:C₂₁H₁₉ClN₄O
Colore e forma:Solid
Peso molecolare:378.85
Ref: TM-T61594
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HSP90-IN-20
CAS:
- 747414-31-9
HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.
Formula:C₂₆H₃₂N₄O₄
Colore e forma:Solid
Peso molecolare:464.56
Ref: TM-T73011
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Bimoclomol
CAS:
- 130493-03-7
Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.
Formula:C₁₄H₂₀ClN₃O₂
Colore e forma:Solid
Peso molecolare:297.78
Ref: TM-T13580
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CH5138303
CAS:
- 959763-06-5
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
Formula:C₁₉H₁₈ClN₅O₂S
Purezza:98%
Colore e forma:Solid
Peso molecolare:415.9
Ref: TM-T6442
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KUNB31
CAS:
- 2220263-80-7
KUNB31 is a potent and selective inhibitor of Hsp90β.
Formula:C₁₉H₁₈N₂O₃
Colore e forma:Solid
Peso molecolare:322.36
Ref: TM-T69779
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Hsp90-IN-15
CAS:
- 2252283-32-0
Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.
Formula:C₂₃H₂₇F₃N₄
Colore e forma:Solid
Peso molecolare:416.48
Ref: TM-T62163
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Retaspimycin
CAS:
- 857402-23-4
Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).
Formula:C₃₁H₄₅N₃O₈
Purezza:98%
Colore e forma:Solid
Peso molecolare:587.7
Ref: TM-T12726
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BIIB028
CAS:
- 911398-13-5
BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.
Formula:C₁₉H₂₁ClN₅O₅P
Colore e forma:Solid
Peso molecolare:465.83
Ref: TM-T68383

HSP

Trovati 179 prodotti di "HSP"

Vibsanin A

Ref: TM-T68802

6BrCaQ

Ref: TM-T61726

Malonganenone A

Ref: TM-T24429

Displurigen

Ref: TM-T27184

MPC-3100

Ref: TM-T21600

Hsp90-IN-17

Ref: TM-T72996

YM-01 Tosylate

Ref: TM-T29179

Icapamespib HCl

Ref: TM-T69712

CH5015765

Ref: TM-T68228

HSP90-IN-12

Ref: TM-T61938

Grp94-IN-2

Ref: TM-T70088

YM-1

Ref: TM-T73579

BF844

Ref: TM-T61594

HSP90-IN-20

Ref: TM-T73011

Bimoclomol

Ref: TM-T13580

CH5138303

Ref: TM-T6442

KUNB31

Ref: TM-T69779

Hsp90-IN-15

Ref: TM-T62163

Retaspimycin

Ref: TM-T12726

BIIB028

Ref: TM-T68383