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Wee1

Wee1

Gli inibitori di Wee1 prendono di mira la chinasi Wee1, un regolatore chiave del checkpoint G2/M nel ciclo cellulare. Wee1 controlla i tempi della mitosi inibendo le chinasi ciclina-dipendenti (CDK) per prevenire un ingresso prematuro nella mitosi. L'inibizione di Wee1 può portare all'abolizione del checkpoint G2/M, costringendo le cellule con DNA danneggiato a entrare prematuramente in mitosi, spesso risultando nella morte cellulare. Ciò rende gli inibitori di Wee1 particolarmente utili nella terapia del cancro, soprattutto in combinazione con agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una selezione di inibitori di Wee1 di alta qualità per supportare la tua ricerca nel controllo del ciclo cellulare, nella risposta ai danni del DNA e nel trattamento del cancro.

Trovati 14 prodotti di "Wee1"

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  • WEE1-IN-6
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    WEE1-IN-6

    CAS:
    WEE1-IN-6 (compound 110) is an orally active inhibitor of WEE1, displaying a DC50 value of ≤ 100 nM. This compound effectively inhibits cell proliferation [1].
    Formula:C45H52FN11O4
    Colore e forma:Solid
    Peso molecolare:829.96

    Ref: TM-T87631

  • Logo CymitQuimica
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    PKMYT1-IN-3

    PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.
    Formula:C24H26FN5O2
    Colore e forma:Solid
    Peso molecolare:435.49

    Ref: TM-T200211

  • Logo CymitQuimica
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    PKMYT1-IN-4

    PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.
    Formula:C19H15F3N4O2
    Colore e forma:Solid
    Peso molecolare:388.34

    Ref: TM-T201136

  • ZN-c3
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    ZN-c3

    CAS:
    <p>Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.</p>
    Formula:C29H34N8O2
    Purezza:99.98%
    Colore e forma:Solid
    Peso molecolare:526.63

    Ref: TM-T9643

  • PD0166285
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    PD0166285

    CAS:
    <p>PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.</p>
    Formula:C26H27Cl2N5O2
    Purezza:99.23%
    Colore e forma:Solid
    Peso molecolare:512.43

    Ref: TM-T6931

  • WEE1-IN-3
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    WEE1-IN-3

    CAS:
    WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
    Formula:C28H31N7O2
    Purezza:98.33%
    Colore e forma:Solid
    Peso molecolare:497.59

    Ref: TM-T8916

  • Adavosertib
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    Adavosertib

    CAS:
    Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
    Formula:C27H32N8O2
    Purezza:98.65% - 99.86%
    Colore e forma:Solid
    Peso molecolare:500.6

    Ref: TM-T2077

  • RP-6306
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    RP-6306

    CAS:
    <p>Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.</p>
    Formula:C18H20N4O2
    Purezza:98.41% - 99.28%
    Colore e forma:Solid
    Peso molecolare:324.38

    Ref: TM-T60889

  • WEE1-IN-10
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    WEE1-IN-10

    CAS:
    WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.
    Formula:C28H30Cl2N8O
    Purezza:98.18%
    Colore e forma:Solid
    Peso molecolare:565.5

    Ref: TM-T89365

  • WEE1/PKMYT1-IN-1
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    WEE1/PKMYT1-IN-1

    CAS:
    <p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>
    Formula:C16H16N4O3
    Colore e forma:Solid
    Peso molecolare:312.323

    Ref: TM-T204368

  • WEE1-IN-11
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    WEE1-IN-11

    CAS:
    WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.
    Formula:C26H29FN8OS2
    Colore e forma:Solid
    Peso molecolare:552.69

    Ref: TM-T200924

  • PKMYT1-IN-2
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    PKMYT1-IN-2

    CAS:
    <p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>
    Formula:C22H19N5O2
    Colore e forma:Solid
    Peso molecolare:385.42

    Ref: TM-T87219

  • WEE1 degrader 1
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    WEE1 degrader 1

    WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.
    Formula:C30H31N5O3
    Colore e forma:Solid
    Peso molecolare:509.6

    Ref: TM-T201806

  • PKMYT1-IN-9
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    PKMYT1-IN-9

    CAS:
    PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.
    Formula:C17H14FN5O
    Colore e forma:Solid
    Peso molecolare:323.324

    Ref: TM-T206301