Wee1
Gli inibitori di Wee1 prendono di mira la chinasi Wee1, un regolatore chiave del checkpoint G2/M nel ciclo cellulare. Wee1 controlla i tempi della mitosi inibendo le chinasi ciclina-dipendenti (CDK) per prevenire un ingresso prematuro nella mitosi. L'inibizione di Wee1 può portare all'abolizione del checkpoint G2/M, costringendo le cellule con DNA danneggiato a entrare prematuramente in mitosi, spesso risultando nella morte cellulare. Ciò rende gli inibitori di Wee1 particolarmente utili nella terapia del cancro, soprattutto in combinazione con agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una selezione di inibitori di Wee1 di alta qualità per supportare la tua ricerca nel controllo del ciclo cellulare, nella risposta ai danni del DNA e nel trattamento del cancro.
Trovati 19 prodotti per "Wee1".
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ZN-c3
CAS:Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.Formula:C29H34N8O2Purezza:99.98%Colore e forma:SolidPeso molecolare:526.63Ref: TM-T9643
1mg90,00€5mg215,00€1mL*10mM (DMSO)250,00€10mg334,00€25mg620,00€50mg982,00€100mg1.468,00€200mg1.972,00€Myt1-IN-4
Myt1-IN-4 (21) is an orally active, selective inhibitor of membrane-associated tyrosine- and threonine-specific cdc2 inhibitory kinase (Myt1) (Gene name PKMYT1), with an IC50 value of 2.6 nM. It exhibits antitumor properties.Formula:C25H27N7O2Peso molecolare:457.22262WEE1-IN-6
CAS:WEE1-IN-6 (compound 110) is an orally active inhibitor of WEE1, displaying a DC50 value of ≤ 100 nM. This compound effectively inhibits cell proliferation [1].Formula:C45H52FN11O4Colore e forma:SolidPeso molecolare:829.96PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Formula:C19H15F3N4O2Colore e forma:SolidPeso molecolare:388.34WEE1-IN-13
WEE1-IN-13 (Compound 10) is a highly selective inhibitor of the WEE1 kinase (IC50=0.7 nM). It can disrupt the G2/M checkpoint and induce apoptosis in tumor cells. WEE1-IN-13 shows potential for research in solid tumors, including non-small cell lung cancer and ovarian cancer.WEE1-IN-12
CAS:WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. It inhibits the proliferation of HT29 cells (IC50: 1.07 μM) and shows enhanced efficacy when combined with Gemcitabine (IC50: 0.34 μM). WEE1-IN-12 is applicable in the study of tumors such as colon cancer.Formula:C38H38Cl2N10O6Peso molecolare:801.68WEE1/PKMYT1-IN-2
CAS:WEE1/PKMYT1-IN-2 is the axial chiral P configuration of WEE1/PKMYT1-IN-1. WEE1/PKMYT1-IN-1 is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1, exhibiting antiproliferative activity.Formula:C16H16N4O3Peso molecolare:312.33PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formula:C24H26FN5O2Colore e forma:SolidPeso molecolare:435.49WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Formula:C28H31N7O2Purezza:98.33%Colore e forma:SolidPeso molecolare:497.59Ref: TM-T8916
1mg66,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg225,00€25mg398,00€50mg532,00€100mg767,00€200mg1.018,00€PD0166285
CAS:PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.Formula:C26H27Cl2N5O2Purezza:99.23%Colore e forma:Yellow SolidPeso molecolare:512.43Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Formula:C27H32N8O2Purezza:98.65% - 99.86%Colore e forma:SolidPeso molecolare:500.6Ref: TM-T2077
5mg46,00€1mL*10mM (DMSO)49,00€10mg66,00€25mg81,00€50mg96,00€100mg110,00€200mg161,00€500mg260,00€RP-6306
CAS:Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.Formula:C18H20N4O2Purezza:98.41% - 99.75%Colore e forma:SolidPeso molecolare:324.38PKMYT1-IN-9
CAS:PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.Formula:C17H14FN5OColore e forma:SolidPeso molecolare:323.324PKMYT1-IN-2
CAS:PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Formula:C22H19N5O2Colore e forma:SolidPeso molecolare:385.42WEE1-IN-10
CAS:WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Formula:C28H30Cl2N8OPurezza:98.18%Colore e forma:Yellow SolidPeso molecolare:565.5WEE1/PKMYT1-IN-1
CAS:WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.Formula:C16H16N4O3Colore e forma:SolidPeso molecolare:312.323WEE1-IN-14
CAS:WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor, with an IC50 of 0.5 nM determined by L-RB-FEP calculations and 1.0 nM in ADP-Glo kinase assays. Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removing cell cycle regulation, leading to premature mitotic failure and subsequent tumor cell apoptosis. Thus, WEE1-IN-14 serves as a valuable tool for studying cancer biology.Formula:C25H25Cl2N7OPeso molecolare:510.42WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formula:C26H29FN8OS2Colore e forma:SolidPeso molecolare:552.69WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Formula:C30H31N5O3Colore e forma:SolidPeso molecolare:509.6
