Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 457 prodotti di "Metiltransferasi del DNA"
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PRMT5-IN-32
CAS:PRMT5-IN-32, an inhibitor of PRMT5, inhibits HCT116 cell proliferation with an IC50 of 0.13 μM [1].Formula:C27H21F4N5O2Colore e forma:SolidPeso molecolare:523.48(2R)-Octyl-α-hydroxyglutarate sodium
CAS:(Sodium) (2R)-Octyl-α-hydroxyglutarate is the sodium salt variant of (2R)-Octyl-α-hydroxyglutarate, which has been shown to possess anti-inflammatory properties [1].Formula:C13H23NaO5Colore e forma:SolidPeso molecolare:282.31YEATS4 binder-1
YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a bindingFormula:C23H34N4O3Colore e forma:SolidPeso molecolare:414.54HBI-2375
CAS:HBI-2375 (HYBI-084) is a selective inhibitor that penetrates the blood-brain barrier and is orally active, targeting the MLL1-WDR5 interaction. It inhibits WDR5 with an IC50 of 4.48 nM and demonstrates antiproliferative activity in MV4;11 leukemia cells with an IC50 of 3.17 µM. Furthermore, HBI-2375 disrupts histone methyltransferase activity in cancer cells and is useful for researching leukemia, glioma, and glioblastoma.Formula:C29H36ClF2N9O2Colore e forma:SolidPeso molecolare:616.11MRK-740-NC
CAS:MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.Formula:C25H31N5O3Colore e forma:SolidPeso molecolare:449.55rel-A-395 hydrochloride
CAS:rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Formula:C26H36ClFN4O2SColore e forma:SolidPeso molecolare:523.11HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Formula:C18H19N3O3Colore e forma:SolidPeso molecolare:325.36(1-Nitroethene-1,2-diyl)dibenzene
CAS:(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formula:C14H11NO2Colore e forma:SolidPeso molecolare:225.24RL5a
CAS:RL5a (compound C23) is a novel inhibitor of SETD8.Formula:C17H19N3OColore e forma:SolidPeso molecolare:281.35MMSET-IN-1
CAS:MMSET-IN-1 is an inhibitor of multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) .Formula:C18H29N7O5Purezza:98%Colore e forma:SolidPeso molecolare:423.47Octyl-α-hydroxyglutarate
CAS:Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.
Formula:C13H24O5Peso molecolare:260.33SGC6870N
CAS:SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.
Formula:C23H21BrN2O2SPeso molecolare:469.39PRMT5-IN-50
CAS:PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formula:C26H23F3N6OColore e forma:SolidPeso molecolare:492.496RK-0080552
CAS:RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.Formula:C12H6N6O2Colore e forma:SolidPeso molecolare:266.215TDI-015051
CAS:TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Formula:C22H22FN5O4SColore e forma:SolidPeso molecolare:471.505PRMT5-IN-37
CAS:PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.Formula:C21H15F4N5O2Colore e forma:SolidPeso molecolare:445.37PRMT5-IN-49
CAS:PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.Formula:C19H22N2O2Colore e forma:SolidPeso molecolare:310.39NSD2-PWWP1-IN-2
CAS:NSD2-PWWP1-IN-2 (compound 33) is a potent NSD2-PWWP1 inhibitor, exhibiting an IC50 value of 1.49 µM, indicating its potential utility in cancer research.Formula:C29H30N4Colore e forma:SolidPeso molecolare:434.575PRMT5-IN-3
CAS:PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.Formula:C22H23F3N4O3Colore e forma:SolidPeso molecolare:448.44MS117
MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1].Formula:C17H22N4OColore e forma:SolidPeso molecolare:298.38EZH2-IN-12
EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.Formula:C23H23Cl2N3O3Colore e forma:SolidPeso molecolare:460.35PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Formula:C25H24N4OColore e forma:SolidPeso molecolare:396.48WDR5-IN-5
CAS:WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.Formula:C29H29F3N6OColore e forma:SolidPeso molecolare:534.58PRMT5-IN-1 hydrochloride
PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.Formula:C19H20Cl2N4O5Colore e forma:SolidPeso molecolare:455.29NSD2-PWWP1-IN-3
CAS:NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.
Formula:C34H39N5O2Colore e forma:SolidPeso molecolare:549.706Pociredir
CAS:Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.Formula:C22H18FN5O2Colore e forma:SolidPeso molecolare:403.41PRMT5-MTA-IN-3
CAS:PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.Formula:C19H17F3N6O3Colore e forma:SolidPeso molecolare:434.372MM-589
CAS:MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formula:C28H44N8O5Purezza:98%Colore e forma:SolidPeso molecolare:572.70MS8511
CAS:MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.Formula:C28H41N5O3Colore e forma:SolidPeso molecolare:495.66PRMT5-IN-21
PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.Formula:C18H18F2N6O3Colore e forma:SolidPeso molecolare:404.37O6BTG-C8-αGlu
CAS:O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.Formula:C24H34BrN5O7SColore e forma:SolidPeso molecolare:616.525NSD2-PWWP1-IN-1
CAS:NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.Formula:C28H30N4Colore e forma:SolidPeso molecolare:422.565EED ligand 1
EED ligand 1: potent PRC2 inhibitor targeting EED subunit.Formula:C19H19FN8OColore e forma:SolidPeso molecolare:394.41MS8815
CAS:MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.Formula:C65H87N9O8SColore e forma:SolidPeso molecolare:1154.51RU-0415529
CAS:RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Formula:C21H29N3O4SColore e forma:SolidPeso molecolare:419.538(Rac)-RG108
CAS:(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.
Formula:C19H14N2O4Colore e forma:SolidPeso molecolare:334.326CARM1-IN-3 dihydrochloride
CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).Formula:C24H34Cl2N4O2Colore e forma:SolidPeso molecolare:481.46W4275
CAS:W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.Formula:C25H36N6O3Colore e forma:SolidPeso molecolare:468.59GSK3368715
CAS:GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50sFormula:C20H38N4O2Purezza:98%Colore e forma:SolidPeso molecolare:366.54PF-06726304 acetate
CAS:PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.Formula:C24H25Cl2N3O5Purezza:98%Colore e forma:SolidPeso molecolare:506.38Dot1L-IN-1
CAS:The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.Formula:C32H36ClN9O2SPurezza:98%Colore e forma:SolidPeso molecolare:646.21GSK3368715 3HCl
CAS:GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formula:C20H41Cl3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:475.92MM-589 TFA
CAS:MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formula:C30H45F3N8O7Purezza:98%Colore e forma:SolidPeso molecolare:686.72PRMT5-IN-18
CAS:PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.Formula:C32H42N4O4Colore e forma:SolidPeso molecolare:546.70PRMT5-IN-48
CAS:PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).Formula:C30H37N5O3Colore e forma:SolidPeso molecolare:515.646GSK3368715 dihydrochloride
CAS:GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.Formula:C20H40Cl2N4O2Purezza:99.66% - 99.66%Colore e forma:SolidPeso molecolare:439.46ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Formula:C26H25FN6OPurezza:98.08%Colore e forma:SolidPeso molecolare:456.52Ref: TM-T87073
1mg84,00€5mg165,00€10mg237,00€25mg402,00€50mg515,00€100mg774,00€1mL*10mM (DMSO)Prezzo su richiestaLLY-283
CAS:LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.Formula:C17H18N4O4Purezza:99.49%Colore e forma:SolidPeso molecolare:342.35AMG-193
CAS:AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.Formula:C22H19F3N4O3Purezza:99.52%Colore e forma:SolidPeso molecolare:444.41EZM0414
CAS:EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.Formula:C22H29FN4O2Purezza:99.58%Colore e forma:SolidPeso molecolare:400.49BRD0639
CAS:BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.Formula:C21H22ClN5O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:475.95Sinefungin
CAS:Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viralFormula:C15H23N7O5Purezza:98% - 98.12%Colore e forma:SolidPeso molecolare:381.39EHMT2-IN-2
CAS:EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.Formula:C21H22N6OColore e forma:SolidPeso molecolare:374.44CARM1-IN-1 hydrochloride
CAS:CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.Formula:C26H22Br2ClNO3Colore e forma:SolidPeso molecolare:591.72BLL5 Maleate
CAS:BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.Formula:C21H21N3Purezza:98%Colore e forma:SolidPeso molecolare:315.41Igermetostat
CAS:Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].
Formula:C32H46N4O4Purezza:98%Colore e forma:SolidPeso molecolare:550.73BBDDL2059
CAS:BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.
Formula:C27H36N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:512.66Ref: TM-T79200
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