Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 457 prodotti di "Metiltransferasi del DNA"
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PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Formula:C55H60FN11O8SPurezza:98%Colore e forma:SolidPeso molecolare:1054.2TB22
TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.Colore e forma:Odour SolidA-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Formula:C29H38Cl2N4O4Colore e forma:SolidPeso molecolare:577.54UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Formula:C47H70N6O8Purezza:98%Colore e forma:SolidPeso molecolare:847.09PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Formula:C50H58FN11O6SPurezza:98%Colore e forma:SolidPeso molecolare:960.13MS1943
CAS:MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formula:C42H54N8O3Purezza:95.41% - 95.82%Colore e forma:SolidPeso molecolare:718.93Ref: TM-T13780
1mg42,00€2mgPrezzo su richiesta5mg88,00€10mg137,00€25mg264,00€50mg464,00€100mg845,00€200mg1.396,00€1mL*10mM (DMSO)127,00€PARP/EZH2-IN-2
PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.Formula:C33H31N7O3Peso molecolare:573.24884MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Colore e forma:SolidPRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Formula:C32H40N4O4Colore e forma:SolidPeso molecolare:544.696EPZ-719
CAS:EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.Formula:C22H31FN4O3SColore e forma:SolidPeso molecolare:450.57Chaetocin
CAS:<p>Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.</p>Formula:C30H28N6O6S4Purezza:98.36% - 98.82%Colore e forma:SolidPeso molecolare:696.84SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryPurezza:98%Colore e forma:Odour SolidCARM1 degrader-2
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associatedFormula:C72H100N12O7SPurezza:98%Colore e forma:SolidPeso molecolare:1277.71PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Formula:C25H23F3N6OColore e forma:SolidPeso molecolare:480.495EZH2-IN-15
CAS:A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Formula:C32H44N4O4Purezza:99.88%Colore e forma:SolidPeso molecolare:548.72Ref: TM-T67883
1mg136,00€5mg326,00€10mg497,00€25mg790,00€50mg1.063,00€100mg1.431,00€200mg1.918,00€1mL*10mM (DMSO)395,00€UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Formula:C67H104N10O17SColore e forma:SolidPeso molecolare:1353.68MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Colore e forma:Odour SolidFTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Formula:C22H19ClFN5O2Colore e forma:SolidPeso molecolare:439.87MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Formula:C15H26Cl2N2OPurezza:99.9%Colore e forma:SolidPeso molecolare:321.28PRMT5-IN-4
CAS:PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Formula:C11H13N3O4SColore e forma:SolidPeso molecolare:283.3MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Formula:C64H84F3N11O7SColore e forma:SolidPeso molecolare:1208.5XF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Formula:C52H59F4N9O7SColore e forma:SolidPeso molecolare:1030.14Nanaomycin A
CAS:Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).Formula:C16H14O6Purezza:98%Colore e forma:SolidPeso molecolare:302.28BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormula:C24H25NO4Purezza:99.98%Colore e forma:SolidPeso molecolare:391.46SGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Formula:C41H47ClN6O6SPurezza:98%Colore e forma:SolidPeso molecolare:787.37UNC-4219 TFA
CAS:UNC4219 is a control for UNC3866, blocking Kme reader function in CBX & CDY chromodomains.Formula:C46H69F3N6O10Purezza:98%Colore e forma:SolidPeso molecolare:923.085SAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Formula:C155H256N48O40Purezza:98%Colore e forma:SolidPeso molecolare:3432.05EPZ-025654
CAS:EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Formula:C29H33ClN8O3Colore e forma:SolidPeso molecolare:577.08PROTAC PRMT3 degrader 1
PROTAC PRMT3 degrader 1 (compound 11) is a PROTAC molecule targeting PRMT3 for degradation. It effectively inhibits the growth of acute leukemia cells.Colore e forma:Odour SolidG9a-IN-3
G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.Formula:C26H29N5O3Colore e forma:SolidPeso molecolare:459.22704EEDi-5285
CAS:<p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>Formula:C24H22FN5O3SPurezza:100%Colore e forma:SolidPeso molecolare:479.53CM112
CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.Formula:C39H61N5O7Colore e forma:SolidPeso molecolare:711.4571NSC 370284
CAS:NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.Formula:C21H25NO6Purezza:99.74%Colore e forma:SolidPeso molecolare:387.43PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Formula:C20H7Br6NO5Colore e forma:SolidPeso molecolare:820.702PRMT5-MTA-IN-2
PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.Formula:C30H25F2N7O2Colore e forma:SolidPeso molecolare:553.56CPI-1328
CAS:CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Formula:C28H36ClN3O4SColore e forma:SolidPeso molecolare:546.12WDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Colore e forma:Odour SolidUNC10013
UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.Colore e forma:Odour SolidGSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Formula:C25H31N7OSColore e forma:SolidPeso molecolare:477.62DC-S239
CAS:Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Formula:C15H15N3O5SPurezza:99.37%Colore e forma:SolidPeso molecolare:349.36Ref: TM-T60002
2mg43,00€5mg66,00€10mg96,00€25mg187,00€50mg304,00€100mg482,00€200mg658,00€1mL*10mM (DMSO)73,00€MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Colore e forma:Odour SolidEZH2-IN-4
CAS:EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.Formula:C29H41N3O3SColore e forma:SolidPeso molecolare:511.73EEDi-5273
CAS:EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Formula:C26H22F4N6O2Colore e forma:SolidPeso molecolare:526.496Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formula:C34H37ClF3N9O4SColore e forma:SolidPeso molecolare:760.23MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Formula:C28H42ClN5O3Purezza:98.9% - 98.96%Colore e forma:SolidPeso molecolare:532.12PRMT5-IN-34
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative protein arginine methyltransferase 5 (PRMT5/MAT).Formula:C23H19F2N5O2Peso molecolare:435.15068AS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Formula:C36H41ClN6O3S2Colore e forma:SolidPeso molecolare:705.332DDO-2093
CAS:DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Formula:C29H37ClFN9O3Colore e forma:SolidPeso molecolare:614.12EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).Formula:C25H40Cl2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:515.51Anticancer agent 126
Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYCFormula:C25H11BBr2F2N2O3S4Purezza:98%Colore e forma:SolidPeso molecolare:724.23
