Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 455 prodotti di "Metiltransferasi del DNA"
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AMI-1 free acid
CAS:<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Formula:C21H16N2O9S2Purezza:97.8%Colore e forma:SolidPeso molecolare:504.49PROTAC EZH2 Degrader-1
CAS:PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.Formula:C54H67N7O8Colore e forma:SolidPeso molecolare:942.15MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Formula:C28H42ClN5O3Colore e forma:SolidPeso molecolare:532.12O6BTG-octylglucoside
CAS:O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Formula:C24H34BrN5O7SPurezza:98%Colore e forma:SolidPeso molecolare:616.53(R)-GSK-3685032
CAS:(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.Formula:C22H24N6OSColore e forma:SolidPeso molecolare:420.545-Aza-2'-deoxycytidine
CAS:Formula:C8H12N4O4Purezza:>98.0%(HPLC)Colore e forma:White to Almost white powder to crystalPeso molecolare:228.21O6-Benzylguanine
CAS:Formula:C12H11N5OPurezza:>98.0%(T)(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:241.25DA-3003-1
CAS:DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.Formula:C15H16ClN3O3Purezza:99.27% - 99.79%Colore e forma:SolidPeso molecolare:321.76EHMT2-IN-1
CAS:EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.Formula:C18H23N7OColore e forma:SolidPeso molecolare:353.42EZM0414 TFA
CAS:EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.Formula:C24H30F4N4O4Purezza:98.88%Colore e forma:SolidPeso molecolare:514.51(R)-HH2853
CAS:(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.Formula:C31H36F3N7O3Purezza:97.53% - 98.85%Colore e forma:SolidPeso molecolare:611.665'-Azido-5'-deoxyadenosine
CAS:5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.Formula:C10H12N8O3Purezza:99.84%Colore e forma:SolidPeso molecolare:292.25PR5-LL-CM01
CAS:PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.Formula:C23H27N7Colore e forma:SolidPeso molecolare:401.51AZ505 ditrifluoroacetate
CAS:AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Formula:C33H40Cl2F6N4O8Colore e forma:SolidPeso molecolare:805.59EPZ020411
CAS:EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).Formula:C25H38N4O3Colore e forma:SolidPeso molecolare:442.6AS-85
CAS:AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Formula:C26H28F3N5O3S2Purezza:98.96%Colore e forma:SolidPeso molecolare:579.66TP-064
CAS:TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.Formula:C28H34N4O2Purezza:97.85%Colore e forma:SolidPeso molecolare:458.6Ref: TM-T28996
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg245,00€50mg487,00€100mg710,00€1mL*10mM (DMSO)80,00€AMI-1
CAS:<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Formula:C21H14N2Na2O9S2Purezza:97.53% - 99.9%Colore e forma:DrypowderPeso molecolare:548.45GSK591
CAS:GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).Formula:C22H28N4O2Purezza:99.35% - 99.45%Colore e forma:SolidPeso molecolare:380.48Ref: TM-T6853
1mg48,00€2mg62,00€5mg100,00€10mg144,00€25mg283,00€50mg425,00€100mg597,00€1mL*10mM (DMSO)106,00€SGC2085 HCl
CAS:SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.Formula:C19H24N2O2·HClPurezza:99.91%Colore e forma:SolidPeso molecolare:348.87Ref: TM-T4013
1mg93,00€2mg150,00€5mg190,00€10mg343,00€25mg567,00€50mg825,00€100mg1.130,00€1mL*10mM (DMSO)244,00€Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Formula:C34H44N4O4Purezza:98.24% - ≥95%Colore e forma:SolidPeso molecolare:572.74Ref: TM-T1788
2mg35,00€5mg52,00€10mg73,00€25mg92,00€50mg92,00€100mg153,00€500mg383,00€1mL*10mM (DMSO)66,00€MRTX9768
CAS:MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.Formula:C24H17FN6OPurezza:97.02%Colore e forma:SolidPeso molecolare:424.43Pinometostat
CAS:Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.Formula:C30H42N8O3Purezza:99.19% - 99.86%Colore e forma:SolidPeso molecolare:562.713-deazaneplanocin A HCl
CAS:3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.Formula:C12H15ClN4O3Purezza:93.24% - 98.9%Colore e forma:SolidPeso molecolare:298.73LLY-507
CAS:LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.Formula:C36H42N6OPurezza:99.58% - 99.93%Colore e forma:SolidPeso molecolare:574.76Ref: TM-T6879
1mg44,00€2mg55,00€5mg85,00€10mg138,00€25mg304,00€50mg552,00€100mg787,00€1mL*10mM (DMSO)110,00€OICR-9429
CAS:<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Formula:C29H32F3N5O3Purezza:97.07% - 99.93%Colore e forma:SolidPeso molecolare:555.59HLCL-61 hydrochloride
CAS:HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.Formula:C23H24N2O·ClHPurezza:99.88% - 99.95%Colore e forma:SolidPeso molecolare:380.91BRD9539
CAS:BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μMFormula:C24H21N3O3Purezza:98% - 99.57%Colore e forma:SolidPeso molecolare:399.44MS023
CAS:MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,Formula:C17H25N3OPurezza:98.31% - 99.87%Colore e forma:SolidPeso molecolare:287.4Ref: TM-T6900
1mg39,00€2mg51,00€5mg88,00€10mg119,00€25mg243,00€50mg378,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)84,00€MR837
CAS:MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.Formula:C16H14N2OSPurezza:99.77% - 99.85%Colore e forma:SolidPeso molecolare:282.36Ref: TM-T8879
2mg40,00€5mg58,00€10mg96,00€25mg145,00€50mg255,00€100mg375,00€200mg530,00€1mL*10mM (DMSO)70,00€Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Formula:C9H12N2O5Purezza:99.04% - >99.99%Colore e forma:SolidPeso molecolare:228.2UNC0642
CAS:UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Formula:C29H44F2N6O2Purezza:98.75% - 99.5%Colore e forma:SolidPeso molecolare:546.7Ref: TM-T4166
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg230,00€50mg378,00€100mg567,00€200mg825,00€1mL*10mM (DMSO)95,00€SETDB1-TTD-IN-1
CAS:SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.Formula:C28H31N5O2Purezza:98.26% - 99.96%Colore e forma:SolidPeso molecolare:469.58EED226
CAS:EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.Formula:C17H15N5O3SPurezza:98.14% - 99.33%Colore e forma:SolidPeso molecolare:369.4Succinic acid sodium
CAS:Succinic acid sodium is an orally active anxiolytic.Formula:C4H6O4·xNaColore e forma:Solidγ-Oryzanol
CAS:γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in theFormula:C40H58O4Purezza:mixture - mixtureColore e forma:White Or White Crystalline Powder OdourlessPeso molecolare:602.9SGC2085
CAS:SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).Formula:C19H24N2O2Purezza:99.61% - 99.71%Colore e forma:SolidPeso molecolare:312.41Ref: TM-T7089
1mg88,00€2mg119,00€5mg227,00€10mg341,00€25mg563,00€50mg820,00€100mg1.130,00€1mL*10mM (DMSO)160,00€OTS186935 hydrochloride
OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.Formula:C25H27Cl2N5O2Colore e forma:SolidPeso molecolare:522.31BIX-01294
CAS:BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).Formula:C28H38N6O2Purezza:98.58% - 99.64%Colore e forma:SolidPeso molecolare:490.64Ref: TM-T7697
1mg40,00€5mg85,00€10mg117,00€25mg207,00€50mg311,00€100mg472,00€200mg642,00€1mL*10mM (DMSO)131,00€UNC1215
CAS:UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).Formula:C32H43N5O2Purezza:98% - 99.04%Colore e forma:SolidPeso molecolare:529.72SGC0946
CAS:SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.Formula:C28H40BrN7O4Purezza:98% - 99.82%Colore e forma:SolidPeso molecolare:618.57Gambogenic acid
CAS:Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Formula:C38H46O8Purezza:97.47% - 99.6%Colore e forma:SolidPeso molecolare:630.77Ref: TM-T8201
1mg49,00€5mg97,00€10mg160,00€25mg283,00€50mg452,00€100mg723,00€200mg938,00€1mL*10mM (DMSO)135,00€EPZ004777
CAS:EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Formula:C28H41N7O4Purezza:98.99% - 99.32%Colore e forma:SolidPeso molecolare:539.67A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFormula:C18H16Cl2N4Purezza:99.92%Colore e forma:SolidPeso molecolare:359.25UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Formula:C36H59N7O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:621.9CM-579 trihydrochloride
CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.Formula:C29H43Cl3N4O3Colore e forma:SolidPeso molecolare:602.04WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Formula:C21H25N3O4Purezza:98% - 99.61%Colore e forma:SolidPeso molecolare:383.44AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Formula:C29H38Cl2N4O4Purezza:98.18%Colore e forma:SolidPeso molecolare:577.54Ref: TM-TQ0100
1mg64,00€5mg137,00€10mg188,00€25mg311,00€50mg487,00€100mg658,00€1mL*10mM (DMSO)168,00€PF-06726304
CAS:PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).Formula:C22H21Cl2N3O3Purezza:98.19% - 99.51%Colore e forma:SolidPeso molecolare:446.33Ref: TM-T12428L
1mg39,00€2mg50,00€5mg81,00€10mg125,00€25mg279,00€50mg505,00€100mg730,00€1mL*10mM (DMSO)88,00€Piribedil
CAS:Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Formula:C16H18N4O2Purezza:99.79% - 99.82%Colore e forma:SolidPeso molecolare:298.34
