Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 455 prodotti di "Metiltransferasi del DNA"
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Pociredir
CAS:Pociredir (FTX-6058), a potent EED inhibitor (KD=0.163 nM), may help in SCD research.Formula:C22H18FN5O2Colore e forma:SolidPeso molecolare:403.41PRMT5-IN-50
CAS:PRMT5-IN-50 is an orally active selective inhibitor of PRMT5, demonstrating good metabolic stability and low clearance in human liver microsomes. It inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC50 values for symmetric arginine methylation inhibition at 1.0 and 536 nM, respectively, and antiproliferative IC50 values at 19 and 1620 nM, respectively. Additionally, PRMT5-IN-50 suppresses tumor growth in mice.Formula:C26H23F3N6OColore e forma:SolidPeso molecolare:492.496GSK3368715 3HCl
CAS:GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formula:C20H41Cl3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:475.92MM-589 TFA
CAS:MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.Formula:C30H45F3N8O7Purezza:98%Colore e forma:SolidPeso molecolare:686.72WDR5-IN-5
CAS:WDR5-IN-5: Selective oral inhibitor for WDR5's WIN site with high affinity (Ki<0.02 nM) and anti-cancer properties. Good pharmacokinetics.Formula:C29H29F3N6OColore e forma:SolidPeso molecolare:534.58HLCL-61
CAS:HLCL-61 is a premier small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).Formula:C23H24N2OColore e forma:SolidPeso molecolare:344.45PRMT5-IN-19
PRMT5-IN-19 is a potent, selective PRMT5 inhibitor with IC50 of 23.9 nM and 47 nM, showing anti-cancer activity by inducing apoptosis.Formula:C25H24N4OColore e forma:SolidPeso molecolare:396.48PRMT5-IN-21
PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5.Formula:C18H18F2N6O3Colore e forma:SolidPeso molecolare:404.37MS8511
CAS:<p>MS8511: Selective, irreversible G9a/GLP inhibitor. IC50: 100 nM (G9a), 140 nM (GLP). Lowers H3K9me2, anti-proliferative. Useful in cancer/AD/PWS research.</p>Formula:C28H41N5O3Colore e forma:SolidPeso molecolare:495.66MRK-740-NC
CAS:MRK-740-NC is an inhibitor of the PRDM7/9 histone methyltransferase. Acting as the negative control compound for MRK-740, MRK-740-NC lacks inhibitory activity on PRDM7 and PRDM9 because the methylpyridine portion of MRK-740 is replaced with a phenyl group.Formula:C25H31N5O3Colore e forma:SolidPeso molecolare:449.55rel-A-395 hydrochloride
CAS:rel-A-395 hydrochloride is the relative configuration of A-395 hydrochloride. A-395 is an antagonist of protein-protein interactions within the polycomb repressive complex 2 (PRC2). It inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 value of 18 nM.Formula:C26H36ClFN4O2SColore e forma:SolidPeso molecolare:523.11WIZ degrader 1
CAS:WIZ degrader 1 (Compound 141) is a degrader of the wide-interval zinc-finger motif (WIZ) with an AC50 of 2 nM. It can induce the expression of fetal hemoglobin (HbF), exhibiting an EC50 value of 6 mM. WIZ degrader 1 is used in the research of genetic blood disorders.Formula:C25H33F2N5O2Peso molecolare:473.56NSD2-PWWP1-IN-3
CAS:<p>NSD2-PWWP1-IN-3 (compound 36) is an effective inhibitor of NSD2-PWWP1, with an IC50 value of 8.05 µM. It has potential applications in cancer research.</p>Formula:C34H39N5O2Colore e forma:SolidPeso molecolare:549.706HbF inducer-1
HbF inducer-1 is a fetal hemoglobin inducer which is orally bioavailable.Formula:C18H19N3O3Colore e forma:SolidPeso molecolare:325.36PRMT5-IN-44
CAS:PRMT5-IN-44 (compound 12) is an inhibitor of PRMT5, specifically utilized in cancer research.Formula:C23H19F4N5O2Peso molecolare:473.42SGC6870N
CAS:<p>SGC6870N is inactive against PRMT6 and can be used as a negative control. It is the inactive enantiomer of SGC6870.</p>Formula:C23H21BrN2O2SPeso molecolare:469.39PRMT5-IN-1 hydrochloride
PRMT5 IN-1 hydrochloride is a potent PRMT5 inhibitor (IC50: 11 nM), forms covalent adduct with C449, and converts to an aldehyde in vivo.Formula:C19H20Cl2N4O5Colore e forma:SolidPeso molecolare:455.29Octyl-α-hydroxyglutarate
CAS:<p>Octyl-α-hydroxyglutarate (octyl-2-HG) enhances histone methylation and boosts the viability of LMP1-negative nasopharyngeal carcinoma (NPC) cells.</p>Formula:C13H24O5Peso molecolare:260.33ZL-28-6
CAS:ZL-28-6, a type I PRMT inhibitor (IC50: 18 nM), effectively targets CARM1 (a member of PRMT) within cells and is suitable for cancer research [1].Formula:C18H22Cl2N2OPeso molecolare:353.29(1-Nitroethene-1,2-diyl)dibenzene
CAS:(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.Formula:C14H11NO2Colore e forma:SolidPeso molecolare:225.24
