Metiltransferasi del DNA
Le metiltransferasi del DNA (DNMT) sono enzimi che catalizzano l'aggiunta di gruppi metilici ai residui di citosina nel DNA, portando al silenziamento genico. Una metilazione aberrante del DNA è associata a varie malattie, incluso il cancro. Gli inibitori delle DNMT bloccano l'attività di questi enzimi, portando alla riattivazione dei geni silenziati e all'induzione dell'apoptosi nelle cellule tumorali. Gli inibitori delle DNMT sono ampiamente utilizzati nella ricerca epigenetica e nella terapia del cancro. Presso CymitQuimica, offriamo una gamma di inibitori delle DNMT di alta qualità per supportare la tua ricerca in epigenetica, metilazione del DNA e biologia del cancro.
Trovati 454 prodotti di "Metiltransferasi del DNA"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Formula:C21H36N6O2Colore e forma:SolidPeso molecolare:404.559DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Colore e forma:Odour SolidSW2_110A
CAS:SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.Formula:C42H60N6O7Purezza:98%Colore e forma:SolidPeso molecolare:760.96Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Formula:C34H37ClF3N9O4SColore e forma:SolidPeso molecolare:760.23GSK 591 dihydrochloride
CAS:Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.Formula:C22H30Cl2N4O2Colore e forma:SolidPeso molecolare:453.41WDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Colore e forma:Odour SolidEPZ-025654
CAS:EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Formula:C29H33ClN8O3Colore e forma:SolidPeso molecolare:577.08DDO-2093
CAS:DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Formula:C29H37ClFN9O3Colore e forma:SolidPeso molecolare:614.12C 21
CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Formula:C90H161ClN36O24Purezza:98%Colore e forma:SolidPeso molecolare:2166.94MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Colore e forma:Odour SolidCARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Formula:C27H35ClN6O3Colore e forma:SolidPeso molecolare:527.06PRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Formula:C20H26N6O2Colore e forma:SolidPeso molecolare:382.459PRMT5-IN-11
CAS:PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Formula:C13H17N5O4Colore e forma:SolidPeso molecolare:307.31PARP/EZH2-IN-1
CAS:PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.Formula:C43H41FN8O5Colore e forma:SolidPeso molecolare:768.85MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Colore e forma:Odour SolidML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Colore e forma:Odour SolidMS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Formula:C28H42ClN5O3Purezza:98.9% - 98.96%Colore e forma:SolidPeso molecolare:532.12SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Formula:C45H62Cl3N7O8Colore e forma:SolidPeso molecolare:935.37BBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Formula:C37H47N5O5SColore e forma:SolidPeso molecolare:673.32979FTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Formula:C22H18FN5O2Colore e forma:SolidPeso molecolare:403.417
