Sirtuina
Le sirtuine sono una famiglia di deacetilasi dipendenti dal NAD+ che svolgono un ruolo cruciale nella regolazione di processi cellulari come la riparazione del DNA, l'invecchiamento, il metabolismo e la resistenza allo stress. Le sirtuine influenzano la riparazione del DNA deacetilando le proteine coinvolte nelle vie di riparazione, modulandone così l'attività. Gli inibitori e gli attivatori delle sirtuine sono strumenti preziosi nella ricerca sull'invecchiamento, il cancro e le malattie metaboliche, dove la regolazione della riparazione del DNA e della longevità cellulare è di interesse. Presso CymitQuimica, offriamo una gamma di modulatori di sirtuine di alta qualità per supportare la tua ricerca sulla riparazione del DNA, l'invecchiamento cellulare e la regolazione metabolica.
Trovati 88 prodotti di "Sirtuina"
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Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formula:C11H15N2O5Purezza:98.82% - 99.58%Colore e forma:SolidPeso molecolare:255.25Resveratrol
CAS:<p>Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.</p>Formula:C14H12O3Purezza:99.82% - 99.96%Colore e forma:Off-White To Tan PowderPeso molecolare:228.24MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Formula:C33H38N4O8Purezza:98% - 99.90%Colore e forma:SoildPeso molecolare:618.68SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Formula:C15H21N5O3S2Purezza:98.26%Colore e forma:SolidPeso molecolare:383.49SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurezza:98.68%Colore e forma:SolidPeso molecolare:561.06Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Formula:C17H15FN2OPurezza:99.54%Colore e forma:SolidPeso molecolare:282.31Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formula:C34H46N6O6SPurezza:99.52%Colore e forma:SolidPeso molecolare:666.83SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Colore e forma:Odour SolidSIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formula:C14H16N2OPurezza:99.58%Colore e forma:SolidPeso molecolare:228.29SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formula:C22H25ClN8O2SPurezza:99.56%Colore e forma:SolidPeso molecolare:501SIRT1 activator 1
<p>SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.</p>Purezza:98%Colore e forma:Odour SolidSIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Formula:C55H91N9O15SColore e forma:SolidPeso molecolare:1150.43BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormula:C24H25NO4Purezza:99.98%Colore e forma:SolidPeso molecolare:391.46SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColore e forma:SolidPeso molecolare:492.5SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Colore e forma:Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Formula:C20H15N3O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:361.42SIRT2-IN-17
<p>SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.</p>Formula:C24H15N3O2SColore e forma:SolidPeso molecolare:409.46MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Formula:C22H19N3OSPurezza:99.9%Colore e forma:SolidPeso molecolare:373.47Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurezza:99.67%Colore e forma:SolidPeso molecolare:349.41Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Formula:C21H20N4O3S2Purezza:98%Colore e forma:SolidPeso molecolare:440.54WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Formula:C25H21N5O2SPurezza:99.33%Colore e forma:SolidPeso molecolare:455.53SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purezza:98%Colore e forma:SolidPeso molecolare:401.35ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formula:C26H29I2NO3Purezza:99.23%Colore e forma:SolidPeso molecolare:657.32Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Formula:C34H51N3O3SPurezza:99.16%Colore e forma:SolidPeso molecolare:581.85Selisistat S-enantiomer
CAS:<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Formula:C13H13ClN2OPurezza:99.86%Colore e forma:SolidPeso molecolare:248.71Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purezza:97.47% - 99.97%Colore e forma:WhitePeso molecolare:1429.15CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurezza:98.92%Colore e forma:SolidPeso molecolare:418.44Nicotinamide riboside chloride
CAS:<p>NR, also SRT647, is a B3 vitamin form; precursor to NAD+.</p>Formula:C11H15ClN2O5Purezza:98.92% - 99.86%Colore e forma:SolidPeso molecolare:290.7AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurezza:98.32% - 99.44%Colore e forma:SolidPeso molecolare:403.45E1231
CAS:<p>E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.</p>Formula:C21H21N3O3Purezza:98.45%Colore e forma:SolidPeso molecolare:363.41YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purezza:99.47%Colore e forma:SolidPeso molecolare:372.18Scopolin
CAS:<p>Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.</p>Formula:C16H18O9Purezza:98.97% - ≥95%Colore e forma:SolidPeso molecolare:354.31Agrimol B
CAS:<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formula:C37H46O12Purezza:99.06% - ≥95%Colore e forma:SolidPeso molecolare:682.753-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Formula:C7H6N4Purezza:99.16% - >99.99%Colore e forma:SolidPeso molecolare:146.15Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurezza:99.33%Colore e forma:SolidPeso molecolare:369.48Dihydrocoumarin
CAS:<p>Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).</p>Formula:C9H8O2Purezza:98.46%Colore e forma:Leaflets Room Temperature (Ntp 1992)Peso molecolare:148.16Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Formula:C44H64O24Purezza:98.24% - 98.82%Colore e forma:Orange Yellow To Reddish Yellow PowderPeso molecolare:976.96Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurezza:98.89% - >99.99%Colore e forma:SolidPeso molecolare:454.63Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurezza:98.53% - 99.94%Colore e forma:SolidPeso molecolare:248.71SRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Formula:C25H24ClN7OSPurezza:98% - 99.93%Colore e forma:SolidPeso molecolare:506.22SRT 1720 dihydrochloride
CAS:SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Formula:C25H25Cl2N7OSPurezza:98.58%Colore e forma:SolidPeso molecolare:542.48Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Formula:C20H24O11Purezza:99.71% - 99.98%Colore e forma:White PowderPeso molecolare:440.40SirReal2
CAS:<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Formula:C22H20N4OS2Purezza:98.96% - 99.75%Colore e forma:SolidPeso molecolare:420.55Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purezza:98.06% - 99.98%Colore e forma:SolidPeso molecolare:514.65AGK2
CAS:<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Formula:C23H13Cl2N3O2Purezza:98.68% - 99.17%Colore e forma:SolidPeso molecolare:434.27Salermide
CAS:<p>Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.</p>Formula:C26H22N2O2Purezza:97.09% - 99.55%Colore e forma:SolidPeso molecolare:394.47Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Formula:C25H19N5OS2Purezza:98% - 99.36%Colore e forma:SolidPeso molecolare:469.58UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purezza:98.31%Colore e forma:SolidPeso molecolare:247.29SRT 1720
CAS:<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Formula:C25H23N7OSPurezza:98.84%Colore e forma:SolidPeso molecolare:469.56Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurezza:99.8%Colore e forma:SolidPeso molecolare:248.71Ophiopogonin D'
CAS:<p>Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.</p>Formula:C44H70O16Purezza:99.77%Colore e forma:SolidPeso molecolare:855.02SRT 2104
CAS:<p>SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.</p>Formula:C26H24N6O2S2Purezza:98.34% - 99.82%Colore e forma:SolidPeso molecolare:516.64OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formula:C19H14N2O6Purezza:97.47% - 98.6%Colore e forma:SolidPeso molecolare:366.32AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Formula:C23H13Cl2N3O2Purezza:98.31%Colore e forma:SolidPeso molecolare:434.27SRT 2183
CAS:<p>SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).</p>Formula:C27H24N4O2SPurezza:97.86%Colore e forma:SolidPeso molecolare:468.57AK-7
CAS:<p>AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.</p>Formula:C19H21BrN2O3SPurezza:98.43% - 99.34%Colore e forma:SolidPeso molecolare:437.35Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purezza:94.14% - 99.05%Colore e forma:Yellow To Brown Crystalline PowderPeso molecolare:286.244'-bromo-Resveratrol
CAS:<p>4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)</p>Formula:C14H11BrO2Purezza:99.00%Colore e forma:SolidPeso molecolare:291.14SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formula:C15H12ClN3OPurezza:99.79%Colore e forma:SolidPeso molecolare:285.73Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurezza:99.36%Colore e forma:SolidPeso molecolare:491.09SRT 1460
CAS:<p>SRT 1460 is a SIRT1 activator.</p>Formula:C26H29N5O4SPurezza:98.25%Colore e forma:SolidPeso molecolare:507.6Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurezza:98.02% - 99.83%Colore e forma:SolidPeso molecolare:360.43Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Formula:C26H22N2O2Purezza:97.12% - 99.96%Colore e forma:SolidPeso molecolare:394.47B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purezza:99.66%Colore e forma:SolidPeso molecolare:396.83MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formula:C21H16BrCl2FN2O6S2Purezza:99.95% - 99.96%Colore e forma:SolidPeso molecolare:626.3SIRT5 inhibitor 5
CAS:SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Formula:C21H14ClN3O3SPurezza:99.33%Colore e forma:SolidPeso molecolare:423.87SIRT5 inhibitor 2
CAS:SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Formula:C18H12Cl2N2O3SPurezza:99.38% - 99.87%Colore e forma:SolidPeso molecolare:407.27SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Formula:C21H22N6OS2Purezza:97.6%Colore e forma:SolidPeso molecolare:438.57SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Formula:C21H28N6O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:460.55Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Formula:C28H27N7O2S2Purezza:99.57% - 99.84%Colore e forma:SolidPeso molecolare:557.69SIRT5 inhibitor 4
CAS:SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Formula:C18H15N3O4SPurezza:99.97%Colore e forma:SolidPeso molecolare:369.39SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Formula:C31H39FN6O6S2Purezza:97.8%Colore e forma:SolidPeso molecolare:674.81SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Formula:C19H14N2O6Purezza:98.77%Colore e forma:SolidPeso molecolare:366.32Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formula:C31H32ClN5O2S2Purezza:99.63%Colore e forma:SolidPeso molecolare:606.2WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Formula:C20H23ClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:406.93Sirtuin-1 inhibitor 1
CAS:<p>Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.</p>Formula:C20H17N3O2Purezza:99.1%Colore e forma:SolidPeso molecolare:331.37Epigenetic factor-IN-1
CAS:<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Formula:C32H34FN5O6S2Purezza:98%Colore e forma:SolidPeso molecolare:667.77SRT3657
CAS:<p>SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.</p>Formula:C40H54N8O6SPurezza:98%Colore e forma:SolidPeso molecolare:774.97SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Formula:C28H32ClN7O3SPurezza:99.77%Colore e forma:SolidPeso molecolare:582.12SIRT-IN-1
CAS:<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Formula:C19H27N5O2SPurezza:99.29%Colore e forma:SolidPeso molecolare:389.52SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormula:C21H30Br3ClN6SPurezza:98%Colore e forma:SolidPeso molecolare:673.73SIRT-IN-6
CAS:<p>SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.</p>Formula:C7H4ClN3OSColore e forma:SolidPeso molecolare:213.644SIRT1-IN-5
CAS:SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.Formula:C21H17N3O3SPurezza:99.97%Colore e forma:SolidPeso molecolare:391.44MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Formula:C25H25NO6Purezza:99.57%Colore e forma:SolidPeso molecolare:435.47Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formula:C28H46N8O6SColore e forma:SolidPeso molecolare:622.78SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formula:C23H23N3O6Colore e forma:SolidPeso molecolare:437.45DCHC
CAS:<p>DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.</p>Formula:C15H8Cl2O3Colore e forma:SolidPeso molecolare:307.128MDL-811
CAS:<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Formula:C25H25BrCl2FN3O5S2Purezza:98%Colore e forma:SolidPeso molecolare:681.42
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