Sirtuina
Le sirtuine sono una famiglia di deacetilasi dipendenti dal NAD+ che svolgono un ruolo cruciale nella regolazione di processi cellulari come la riparazione del DNA, l'invecchiamento, il metabolismo e la resistenza allo stress. Le sirtuine influenzano la riparazione del DNA deacetilando le proteine coinvolte nelle vie di riparazione, modulandone così l'attività. Gli inibitori e gli attivatori delle sirtuine sono strumenti preziosi nella ricerca sull'invecchiamento, il cancro e le malattie metaboliche, dove la regolazione della riparazione del DNA e della longevità cellulare è di interesse. Presso CymitQuimica, offriamo una gamma di modulatori di sirtuine di alta qualità per supportare la tua ricerca sulla riparazione del DNA, l'invecchiamento cellulare e la regolazione metabolica.
Trovati 88 prodotti di "Sirtuina"
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Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Formula:C11H15N2O5Purezza:98.82% - 99.58%Colore e forma:SolidPeso molecolare:255.25Resveratrol
CAS:<p>Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.</p>Formula:C14H12O3Purezza:99.82% - 99.96%Colore e forma:Off-White To Tan PowderPeso molecolare:228.24MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Formula:C33H38N4O8Purezza:98% - 99.90%Colore e forma:SoildPeso molecolare:618.68SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Formula:C15H21N5O3S2Purezza:98.26%Colore e forma:SolidPeso molecolare:383.49SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Formula:C24H29ClN8O4SPurezza:98.68%Colore e forma:SolidPeso molecolare:561.06Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Formula:C17H15FN2OPurezza:99.54%Colore e forma:SolidPeso molecolare:282.31Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formula:C34H46N6O6SPurezza:99.52%Colore e forma:SolidPeso molecolare:666.83SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Colore e forma:Odour SolidSIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Formula:C14H16N2OPurezza:99.58%Colore e forma:SolidPeso molecolare:228.29SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Formula:C22H25ClN8O2SPurezza:99.56%Colore e forma:SolidPeso molecolare:501SIRT1 activator 1
<p>SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.</p>Purezza:98%Colore e forma:Odour SolidSIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Formula:C55H91N9O15SColore e forma:SolidPeso molecolare:1150.43BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFormula:C24H25NO4Purezza:99.98%Colore e forma:SolidPeso molecolare:391.46SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColore e forma:SolidPeso molecolare:492.5SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Colore e forma:Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Formula:C20H15N3O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:361.42SIRT2-IN-17
<p>SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.</p>Formula:C24H15N3O2SColore e forma:SolidPeso molecolare:409.46MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Formula:C22H19N3OSPurezza:99.9%Colore e forma:SolidPeso molecolare:373.47Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurezza:99.67%Colore e forma:SolidPeso molecolare:349.41Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Formula:C21H20N4O3S2Purezza:98%Colore e forma:SolidPeso molecolare:440.54WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Formula:C25H21N5O2SPurezza:99.33%Colore e forma:SolidPeso molecolare:455.53SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Formula:C22H12FN3O4Purezza:98%Colore e forma:SolidPeso molecolare:401.35ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Formula:C26H29I2NO3Purezza:99.23%Colore e forma:SolidPeso molecolare:657.32Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Formula:C34H51N3O3SPurezza:99.16%Colore e forma:SolidPeso molecolare:581.85Selisistat S-enantiomer
CAS:<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Formula:C13H13ClN2OPurezza:99.86%Colore e forma:SolidPeso molecolare:248.71Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Formula:C51H34N6Na6O23S6Purezza:97.47% - 99.97%Colore e forma:WhitePeso molecolare:1429.15CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurezza:98.92%Colore e forma:SolidPeso molecolare:418.44Nicotinamide riboside chloride
CAS:<p>NR, also SRT647, is a B3 vitamin form; precursor to NAD+.</p>Formula:C11H15ClN2O5Purezza:98.92% - 99.86%Colore e forma:SolidPeso molecolare:290.7AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Formula:C19H21N3O5SPurezza:98.32% - 99.44%Colore e forma:SolidPeso molecolare:403.45E1231
CAS:<p>E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.</p>Formula:C21H21N3O3Purezza:98.45%Colore e forma:SolidPeso molecolare:363.41YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFormula:C19H21BO7Purezza:99.47%Colore e forma:SolidPeso molecolare:372.18Scopolin
CAS:<p>Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.</p>Formula:C16H18O9Purezza:98.97% - ≥95%Colore e forma:SolidPeso molecolare:354.31Agrimol B
CAS:<p>1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.</p>Formula:C37H46O12Purezza:99.06% - ≥95%Colore e forma:SolidPeso molecolare:682.753-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Formula:C7H6N4Purezza:99.16% - >99.99%Colore e forma:SolidPeso molecolare:146.15Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurezza:99.33%Colore e forma:SolidPeso molecolare:369.48Dihydrocoumarin
CAS:<p>Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).</p>Formula:C9H8O2Purezza:98.46%Colore e forma:Leaflets Room Temperature (Ntp 1992)Peso molecolare:148.16Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Formula:C44H64O24Purezza:98.24% - 98.82%Colore e forma:Orange Yellow To Reddish Yellow PowderPeso molecolare:976.96Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurezza:98.89% - >99.99%Colore e forma:SolidPeso molecolare:454.63Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Formula:C13H13ClN2OPurezza:98.53% - 99.94%Colore e forma:SolidPeso molecolare:248.71SRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Formula:C25H24ClN7OSPurezza:98% - 99.93%Colore e forma:SolidPeso molecolare:506.22SRT 1720 dihydrochloride
CAS:SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Formula:C25H25Cl2N7OSPurezza:98.58%Colore e forma:SolidPeso molecolare:542.48Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Formula:C20H24O11Purezza:99.71% - 99.98%Colore e forma:White PowderPeso molecolare:440.40SirReal2
CAS:<p>SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.</p>Formula:C22H20N4OS2Purezza:98.96% - 99.75%Colore e forma:SolidPeso molecolare:420.55Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purezza:98.06% - 99.98%Colore e forma:SolidPeso molecolare:514.65AGK2
CAS:<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Formula:C23H13Cl2N3O2Purezza:98.68% - 99.17%Colore e forma:SolidPeso molecolare:434.27Salermide
CAS:<p>Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.</p>Formula:C26H22N2O2Purezza:97.09% - 99.55%Colore e forma:SolidPeso molecolare:394.47Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Formula:C25H19N5OS2Purezza:98% - 99.36%Colore e forma:SolidPeso molecolare:469.58UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purezza:98.31%Colore e forma:SolidPeso molecolare:247.29SRT 1720
CAS:<p>SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.</p>Formula:C25H23N7OSPurezza:98.84%Colore e forma:SolidPeso molecolare:469.56Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Formula:C13H13ClN2OPurezza:99.8%Colore e forma:SolidPeso molecolare:248.71
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