Sirtuina
Le sirtuine sono una famiglia di deacetilasi dipendenti dal NAD+ che svolgono un ruolo cruciale nella regolazione di processi cellulari come la riparazione del DNA, l'invecchiamento, il metabolismo e la resistenza allo stress. Le sirtuine influenzano la riparazione del DNA deacetilando le proteine coinvolte nelle vie di riparazione, modulandone così l'attività. Gli inibitori e gli attivatori delle sirtuine sono strumenti preziosi nella ricerca sull'invecchiamento, il cancro e le malattie metaboliche, dove la regolazione della riparazione del DNA e della longevità cellulare è di interesse. Presso CymitQuimica, offriamo una gamma di modulatori di sirtuine di alta qualità per supportare la tua ricerca sulla riparazione del DNA, l'invecchiamento cellulare e la regolazione metabolica.
Trovati 90 prodotti per "Sirtuina".
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OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Formula:C19H14N2O6Purezza:97.47% - 98.6%Colore e forma:SolidPeso molecolare:366.32AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Formula:C23H13Cl2N3O2Purezza:98.31%Colore e forma:SolidPeso molecolare:434.27SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Formula:C27H24N4O2SPurezza:97.86%Colore e forma:SolidPeso molecolare:468.57Ref: TM-T16932
1mg52,00€2mg69,00€5mg102,00€1mL*10mM (DMSO)105,00€10mg157,00€25mg268,00€50mg408,00€100mg590,00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Formula:C19H21BrN2O3SPurezza:98.43% - 99.34%Colore e forma:White SolidPeso molecolare:437.35Ref: TM-T5490
1mg34,00€2mg47,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg100,00€25mg177,00€50mg313,00€100mg512,00€Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purezza:94.14% - 99.05%Colore e forma:Yellow SolidPeso molecolare:286.244'-bromo-Resveratrol
CAS:4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Formula:C14H11BrO2Purezza:99.00%Colore e forma:SolidPeso molecolare:291.14CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Formula:C22H15FN4O2SPurezza:98.92%Colore e forma:SolidPeso molecolare:418.44SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Formula:C15H12ClN3OPurezza:99.79%Colore e forma:SolidPeso molecolare:285.73Ref: TM-T39233
1mg90,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurezza:99.36%Colore e forma:SolidPeso molecolare:491.09Ref: TM-T8480
1mg37,00€2mg49,00€5mg66,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg133,00€50mg215,00€100mg356,00€SRT 1460
CAS:SRT 1460 is a SIRT1 activator.Formula:C26H29N5O4SPurezza:98.25%Colore e forma:SolidPeso molecolare:507.6Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurezza:98.02% - 99.83%Colore e forma:SolidPeso molecolare:360.43Ref: TM-T4019
1mg38,00€2mg50,00€1mL*10mM (DMSO)63,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purezza:99.66%Colore e forma:SolidPeso molecolare:396.83MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formula:C21H16BrCl2FN2O6S2Purezza:99.95% - 99.96%Colore e forma:White SolidPeso molecolare:626.3SIRT6 activator 12q
CAS:SIRT6 activator 12q is a SIRT6 activator; EC50=5.3 μM; allosteric modulator; metabolism and aging research.Formula:C31H22N2O2Purezza:98.53%Colore e forma:White SolidPeso molecolare:454.522-APQC
CAS:2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.Formula:C23H24FN5OPurezza:99.88%Colore e forma:White SolidPeso molecolare:405.47Ref: TM-T88667
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg212,00€25mg358,00€50mg512,00€100mg707,00€SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Formula:C21H22N6OS2Purezza:97.6%Colore e forma:Yellow SolidPeso molecolare:438.57SIRT5 inhibitor 5
CAS:SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Formula:C21H14ClN3O3SPurezza:99.33%Colore e forma:SolidPeso molecolare:423.87Ref: TM-T72637
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta1mg82,00€5mg170,00€SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Formula:C21H28N6O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:460.55SIRT5 inhibitor 4
CAS:SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Formula:C18H15N3O4SPurezza:99.97%Colore e forma:White SolidPeso molecolare:369.39SIRT5 inhibitor 2
CAS:SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Formula:C18H12Cl2N2O3SPurezza:99.38% - 99.87%Colore e forma:SolidPeso molecolare:407.27SIRT2-IN-11
CAS:SIRT2-IN-11 is a selective SIRT2 inhibitor; IC50=12 nM; increases tubulin acetylation; cancer research tool.Formula:C21H22N2OColore e forma:White SolidPeso molecolare:318.41Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Formula:C28H27N7O2S2Purezza:99.57% - 99.84%Colore e forma:SolidPeso molecolare:557.69Ref: TM-T12920
1mg100,00€5mg203,00€1mL*10mM (DMSO)253,00€10mg323,00€25mg513,00€50mg697,00€100mg888,00€500mg1.783,00€SIRT3 activator 2
CAS:SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColore e forma:SolidPeso molecolare:492.5SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Formula:C19H14N2O6Purezza:98.77%Colore e forma:SolidPeso molecolare:366.32SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Formula:C31H39FN6O6S2Purezza:97.8%Colore e forma:White SolidPeso molecolare:674.81Ref: TM-T12921
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)442,00€10mg502,00€25mg884,00€50mg1.288,00€100mg1.728,00€SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Formula:C28H32ClN7O3SPurezza:99.77%Colore e forma:SolidPeso molecolare:582.12Epigenetic factor-IN-1
CAS:Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.Formula:C32H34FN5O6S2Purezza:98%Colore e forma:SolidPeso molecolare:667.77SIRT-IN-1
CAS:SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).Formula:C19H27N5O2SPurezza:99.29%Colore e forma:SolidPeso molecolare:389.52Ref: TM-T12918
1mg57,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg409,00€50mg670,00€100mg954,00€SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFormula:C21H30Br3ClN6SPurezza:98%Colore e forma:SolidPeso molecolare:673.73Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formula:C20H17N3O2Purezza:99.1% - 99.87%Colore e forma:White SolidPeso molecolare:331.37Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Formula:C31H32ClN5O2S2Purezza:99.63%Colore e forma:Yellow SolidPeso molecolare:606.2SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formula:C40H54N8O6SPurezza:98%Colore e forma:SolidPeso molecolare:774.97CL5D
CAS:CL5D is an activator of the protein deacetylase SIRT6. It significantly enhances the deacetylase activity and catalytic efficiency of SIRT6. CL5D modulates SIRT6 activity by promoting its conformational changes, particularly relying on the Arg-65 residue. This compound can be used to study the activation mechanism of SIRT6 and its roles in metabolism, DNA repair, and aging.Formula:C29H11Cl7N2O6Peso molecolare:731.58SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Formula:C23H23N3O6Colore e forma:SolidPeso molecolare:437.45SIRT-IN-6
CAS:SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Formula:C7H4ClN3OSColore e forma:SolidPeso molecolare:213.644DCHC
CAS:DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.Formula:C15H8Cl2O3Colore e forma:SolidPeso molecolare:307.128Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Formula:C28H46N8O6SColore e forma:SolidPeso molecolare:622.78SIRT2-IN-14
CAS:**SIRT2-IN-14 (Compound 78)** is a selective SIRT2 inhibitor, demonstrating an IC50 value of 0.196 μM [1].Formula:C26H21N3O4Colore e forma:SolidPeso molecolare:439.46SIRT1-IN-5
CAS:SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.Formula:C21H17N3O3SPurezza:99.97%Colore e forma:SolidPeso molecolare:391.44MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Formula:C25H25NO6Purezza:99.57%Colore e forma:Yellow SolidPeso molecolare:435.47
