Recettore degli androgeni
Il recettore degli androgeni (AR) è un recettore ormonale nucleare che viene attivato dal legame con gli androgeni, come il testosterone e il diidrotestosterone. Questo recettore svolge un ruolo cruciale nello sviluppo e nel mantenimento delle caratteristiche maschili, nonché nella regolazione di diversi processi fisiologici, tra cui la crescita muscolare, la libido e la densità ossea. Gli inibitori del recettore degli androgeni sono ampiamente studiati nel contesto del cancro alla prostata, dove la segnalazione dell'AR è spesso sovraregolata. Presso CymitQuimica, offriamo una gamma di modulatori del recettore degli androgeni di alta qualità per supportare la tua ricerca in endocrinologia, biologia del cancro e regolazione ormonale.
Trovati 229 prodotti di "Recettore degli androgeni"
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Anticancer agent 135
<p>Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7</p>Formula:C23H21F3N4OSPurezza:98%Colore e forma:SolidPeso molecolare:458.5RLA-5331
RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.Formula:C40H43F3N6O7SColore e forma:SolidPeso molecolare:808.87PROTAC AR Degrader-8
CAS:PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 μM and 0.14 μM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 μM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 μM and 1.11 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33; Black: linker; Blue: ligand for E3 ligase Cereblon]Formula:C40H41N5O7Colore e forma:SolidPeso molecolare:703.783ARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Formula:C62H74ClFN8O7SColore e forma:SolidPeso molecolare:1129.83LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Colore e forma:Odour SolidGalloylalbiflorin
CAS:Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.Formula:C30H32O15Colore e forma:SolidPeso molecolare:632.57ARD-266
CAS:ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase that induces the degradation of AR proteins and is useful in prostate cancer research.Formula:C52H59ClN6O7Purezza:99.89%Colore e forma:SolidPeso molecolare:915.51PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Formula:C43H49ClN6O5Colore e forma:SolidPeso molecolare:765.339ARD-61
CAS:ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Formula:C61H71ClN8O7SColore e forma:SolidPeso molecolare:1095.8AR ligand-33
<p>AR ligand-33 is a ligand for the androgen receptor (AR), and it can be used as a target protein ligand for the synthesis of PROTAC AR Degrader-8.</p>Formula:C25H28N2O3Colore e forma:SolidPeso molecolare:404.501BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Formula:C42H46ClN5O7Colore e forma:SolidPeso molecolare:767.308582-sec-Butylphenol
CAS:2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.Formula:C10H14OColore e forma:SolidPeso molecolare:150.22Ludaterone
CAS:Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.Formula:C20H25ClO5Colore e forma:SolidPeso molecolare:380.86RD162
CAS:RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).Formula:C22H16F4N4O2SPurezza:99.71%Colore e forma:SolidPeso molecolare:476.45Ref: TM-T21740
1mg47,00€5mg119,00€10mg187,00€25mg393,00€50mg585,00€100mg832,00€1mL*10mM (DMSO)144,00€Dehydroisoandrosterone 3-acetate
CAS:Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.Formula:C21H30O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:330.46PROTAC AR-NTD degrader 1
<p>PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal</p>Formula:C41H47ClN6O7Purezza:98%Colore e forma:SolidPeso molecolare:771.3Dipropyl phthalate
CAS:Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Formula:C14H18O4Purezza:98.62%Colore e forma:SolidPeso molecolare:250.29PROTAC AR-V7 degrader-1
CAS:Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.Formula:C41H52N6O6S2Colore e forma:SolidPeso molecolare:789.023-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Colore e forma:Odour SolidODM-204
CAS:ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).Formula:C20H21F3N4Purezza:98%Colore e forma:SolidPeso molecolare:374.40RLA-4842
RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.Formula:C42H46F3N5O8SColore e forma:SolidPeso molecolare:837.9Lambertianic acid
CAS:Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formula:C20H28O3Purezza:98%Colore e forma:SolidPeso molecolare:316.441ARCC-4
CAS:ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.Formula:C53H56F3N7O7S2Purezza:98%Colore e forma:SolidPeso molecolare:1024.18Adrenocorticotropic hormone
CAS:ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.Colore e forma:SolidARD-2051
CAS:ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading ARFormula:C43H45ClN8O5Purezza:98%Colore e forma:SolidPeso molecolare:789.322-Ethylhexyl trans-4-methoxycinnamate
CAS:2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.Formula:C18H26O3Purezza:98.92%Colore e forma:Pale Yellow LiquidPeso molecolare:290.4Gridegalutamide
CAS:Gridegalutamide exhibits anti-androgen and anti-tumor activities.Formula:C41H45F3N8O5SColore e forma:SolidPeso molecolare:818.91Cl-4AS-1
CAS:steroidal androgen receptor agonistFormula:C26H33ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:441.01K2-B4-5e
K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.Formula:C52H49ClN8O6SPeso molecolare:948.31843Androgen receptor antagonist 9
CAS:Androgen Receptor Antagonist 9 (compound 28) serves as an antagonist to the androgen receptor [1].Formula:C19H14F3N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:405.39Inocoterone acetate
CAS:Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.Formula:C18H26O3Colore e forma:SolidPeso molecolare:290.40Linuron
CAS:Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Formula:C9H10Cl2N2O2Purezza:99.08%Colore e forma:White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicidePeso molecolare:249.09Enzalutamide-d3
CAS:Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.Formula:C21H16F4N4O2SColore e forma:SolidPeso molecolare:467.45Anti-Androgen receptor Antibody (8R912)
Anti-Androgen receptor Antibody (8R912) is a Mouse antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (8R912) can be used in ICC/IF.Colore e forma:Odour LiquidAnti-Androgen receptor Antibody (7Q574)
Anti-Androgen receptor Antibody (7Q574) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (7Q574) can be used in ELISA, WB, IHC.Colore e forma:Odour LiquidMK-0773
CAS:MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.Formula:C27H34FN5O2Purezza:98.38% - 99.14%Colore e forma:SolidPeso molecolare:479.59Ref: TM-T16090
1mg87,00€2mg111,00€5mg180,00€10mg274,00€25mg464,00€50mgPrezzo su richiesta1mL*10mM (DMSO)187,00€Anti-Androgen receptor Antibody (8H883)
Anti-Androgen receptor Antibody (8H883) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (8H883) can be used in ELISA, IHC.Colore e forma:Odour LiquidARD-1676
CAS:ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand.Formula:C44H46ClN7O5Purezza:98%Colore e forma:SolidPeso molecolare:788.33Alternariol (Standard)
CAS:Alternariol (Standard) is the standard substance of Alternariol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.Formula:C14H10O5Peso molecolare:258.23Estradiol valerate
CAS:β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.Formula:C23H32O3Purezza:99.11% - 99.9%Colore e forma:NaPeso molecolare:356.51Tricaprin (Standard)
CAS:Tricaprin (Standard) is the standard substance of Tricaprin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Glycerol Tridecanoate is an orally active precursor (DA precursor) of caprylic acid that can be hydrolyzed to caprylic acid. It is a major component of medium chain triglycerides (MCT) and has antiandrogenic and antihyperglycemic properties. It can be used as an additive in food, pharmaceuticals and cosmetics.Formula:C33H62O6Colore e forma:SolidPeso molecolare:554.84Dehydroepiandrosterone-d2
CAS:Dehydroepiandrosterone-d2 is a deuterated compound of Dehydroepiandrosterone.Formula:C19H26D2O2Colore e forma:SolidPeso molecolare:290.44Rezvilutamide
CAS:Rezvilutamide (SHR3680) is an orally available androgen receptor inhibitor that crosses the blood-brain barrier and has antitumor activity.Formula:C22H20F3N3O4SPurezza:99.96% - 99.97%Colore e forma:SolidPeso molecolare:479.47D4-abiraterone
CAS:D4-abiraterone is the active metabolite of abiraterone.Δ4-Abiraterone is a inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.Formula:C24H29NOPurezza:99.75% - 99.8%Colore e forma:SolidPeso molecolare:347.49Leelamine hydrochloride
CAS:Leelamine hydrochloride, a pine bark extract, inhibits androgen receptor and CB1, reducing lipid synthesis in prostate cancer.Formula:C20H32ClNPurezza:98%Colore e forma:SolidPeso molecolare:321.93(Rac)-PF-998425
CAS:(Rac)-PF-998425: nonsteroidal AR antagonist, potent & selective, IC50: 26 nM (binding), 90 nM (cellular), potential for androgenetic alopecia study.Formula:C14H14F3NOColore e forma:SolidPeso molecolare:269.267Apalutamide-13C-d3
Apalutamide-13C-d3 is a 13C and 2H labeled Apalutamide. Apalutamide is an androgen receptor (AR) antagonist, used in research on prostate diseases.Formula:CC20H12F4N5O2SD3Colore e forma:SolidPeso molecolare:481.45Fenarimol
CAS:Fenarimol, a pyrimidine-type fungicide, exhibits potent inhibitory activity against BR biosynthesis.Formula:C17H12Cl2N2OColore e forma:SolidPeso molecolare:331.2Darolutamide
CAS:Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).Formula:C19H19ClN6O2Purezza:97.36% - >99.99%Colore e forma:SolidPeso molecolare:398.85Ref: TM-T6915
1mg49,00€2mg70,00€5mg105,00€10mg166,00€25mg264,00€50mg378,00€100mg540,00€200mg772,00€1mL*10mM (DMSO)106,00€3-(7,7-dimethyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-1H-indole-7-carbonitrile
CAS:3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.Formula:C18H14N4OPurezza:98.41%Colore e forma:SolidPeso molecolare:302.33
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