NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 443 prodotti di "NF-κB"
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AS2690168 (free base)
CAS:<p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formula:C17H13F3N4OColore e forma:SolidPeso molecolare:346.306AS2690168 hydrochloride
CAS:<p>AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>Formula:C17H15Cl2F3N4OColore e forma:SolidPeso molecolare:419.228DBMB
CAS:<p>DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.</p>Formula:C24H22N4OColore e forma:SolidPeso molecolare:382.458TLR4/NF-κB/MAPK-IN-1
CAS:<p>TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.</p>Formula:C19H25BrO6Colore e forma:SolidPeso molecolare:429.3oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Formula:C36H58O5Colore e forma:SolidPeso molecolare:570.84GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formula:C22H20O8Colore e forma:SolidPeso molecolare:412.39Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formula:C25H25N5O4Colore e forma:SolidPeso molecolare:459.50RIPK1-IN-19
CAS:<p>RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.</p>Formula:C28H25FN6O2Purezza:98.81%Colore e forma:SolidPeso molecolare:496.544-Octylphenol
CAS:<p>4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.</p>Formula:C14H22OColore e forma:SolidPeso molecolare:206.32Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Formula:C22H20O12Colore e forma:SolidPeso molecolare:476.39TBK1/IKKε-IN-1
CAS:<p>TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).</p>Formula:C28H26N4O5Purezza:98%Colore e forma:SolidPeso molecolare:498.53MAY0132
CAS:<p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>Formula:C16H15ClF3NColore e forma:SolidPeso molecolare:313.745TNFα activity modulator 3
CAS:<p>TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.</p>Formula:C27H24F2N6O2Colore e forma:SolidPeso molecolare:502.52NIK-IN-2
CAS:<p>NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.</p>Formula:C20H22N4O3Colore e forma:SolidPeso molecolare:366.41UBS109
CAS:<p>UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.</p>Formula:C18H17N3OPurezza:99.48%Colore e forma:SolidPeso molecolare:291.35HOIPIN-8 sodium
CAS:<p>HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.</p>Formula:C23H15F2N4NaO3Purezza:97.34%Colore e forma:SolidPeso molecolare:456.38Zharp1-211
CAS:<p>Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.</p>Formula:C24H25N5O4Purezza:99.71%Colore e forma:SolidPeso molecolare:447.49Antiproliferative agent-22
CAS:<p>Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.</p>Formula:C17H13N3O3Purezza:99.20% - 99.27%Colore e forma:SolidPeso molecolare:307.3Tripeptide-41
CAS:<p>Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.</p>Formula:C29H30N4O5Purezza:98%Colore e forma:SolidPeso molecolare:514.572,3-Bis(3-indolylmethyl)indole
CAS:<p>2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.</p>Formula:C26H21N3Colore e forma:SolidPeso molecolare:375.475
