NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 441 prodotti di "NF-κB"
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GSK840
CAS:GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFormula:C21H23N3O3Purezza:99.7%Colore e forma:SolidPeso molecolare:365.43PF-184
PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.Formula:C32H32ClFN6O4Colore e forma:SolidPeso molecolare:619.09Glabrescone C
CAS:<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Formula:C19H22O7Colore e forma:SolidPeso molecolare:362.37CGA-JK3
CAS:CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Formula:C15H19NO3Purezza:98%Colore e forma:SolidPeso molecolare:261.32IMD-biphenylC
CAS:IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.Formula:C35H33N5O3Purezza:98%Colore e forma:SolidPeso molecolare:571.67RIPK1-IN-16
CAS:RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formula:C20H19N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:393.46PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formula:C22H24N4O3SPurezza:98.09% - 99.64%Colore e forma:SolidPeso molecolare:424.52Ref: TM-T12493
1mg81,00€5mg170,00€10mg274,00€25mg518,00€50mg747,00€100mg938,00€1mL*10mM (DMSO)188,00€IRAK inhibitor 3
CAS:IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.Formula:C21H21N5O4SPurezza:98.86%Colore e forma:SolidPeso molecolare:439.49IMD-vanillin
CAS:IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.Formula:C37H45N7O4Purezza:98%Colore e forma:SolidPeso molecolare:651.8Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formula:C42H70O12Purezza:98.46% - 99.13%Colore e forma:SolidPeso molecolare:767.00RIP1 kinase inhibitor 4
CAS:RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].Formula:C23H23N5Purezza:98%Colore e forma:SolidPeso molecolare:369.46Bay 65-1942 (R form)
CAS:Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.Formula:C22H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:395.45RIPK1-IN-4
CAS:<p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>Formula:C23H23N5O2Purezza:99.94%Colore e forma:SolidPeso molecolare:401.46Oditrasertib
CAS:Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.Formula:C14H15F2N3O2Purezza:98.65% - 99.65%Colore e forma:SolidPeso molecolare:295.28Ref: TM-T69726
1mg73,00€5mg159,00€10mg226,00€25mg378,00€50mg547,00€100mg747,00€500mg1.510,00€1mL*10mM (DMSO)145,00€Supercinnamaldehyde
CAS:Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ionFormula:C12H11NO2Purezza:98.89%Colore e forma:SolidPeso molecolare:201.22TLR4/NF-κB/MAPK-IN-1
CAS:TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.Formula:C19H25BrO6Colore e forma:SolidPeso molecolare:429.3TNFα activity modulator 3
CAS:TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.Formula:C27H24F2N6O2Colore e forma:SolidPeso molecolare:502.52AS2690168 (free base)
CAS:AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H13F3N4OColore e forma:SolidPeso molecolare:346.306NLRP3-IN-78
CAS:NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.Formula:C12H5Cl2N3O4S2Colore e forma:SolidPeso molecolare:390.222MAY0132
CAS:MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.Formula:C16H15ClF3NColore e forma:SolidPeso molecolare:313.745Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Formula:C23H17NO2Se2Colore e forma:SolidPeso molecolare:497.31oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Formula:C36H58O5Colore e forma:SolidPeso molecolare:570.84Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Formula:C25H25N5O4Colore e forma:SolidPeso molecolare:459.50NF-κB-IN-6
NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signalingFormula:C14H20N2O3Colore e forma:SolidPeso molecolare:264.32DBMB
CAS:DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.Formula:C24H22N4OColore e forma:SolidPeso molecolare:382.458GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formula:C22H20O8Colore e forma:SolidPeso molecolare:412.39RIPK1-IN-19
CAS:RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.Formula:C28H25FN6O2Purezza:98.81%Colore e forma:SolidPeso molecolare:496.54Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formula:C22H20O12Colore e forma:SolidPeso molecolare:476.39NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Colore e forma:SolidPeso molecolare:366.41K-14585
CAS:K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.Formula:C51H56Cl2N8O4Colore e forma:SolidPeso molecolare:915.95TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formula:C28H26N4O5Purezza:98%Colore e forma:SolidPeso molecolare:498.53AS2690168 hydrochloride
CAS:AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H15Cl2F3N4OColore e forma:SolidPeso molecolare:419.228RIPK2-IN-6
CAS:RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Formula:C26H21NO3Colore e forma:SolidPeso molecolare:395.45Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formula:C17H13N3O3Purezza:99.20% - 99.27%Colore e forma:SolidPeso molecolare:307.3HOIPIN-8 sodium
CAS:HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formula:C23H15F2N4NaO3Purezza:97.34%Colore e forma:SolidPeso molecolare:456.38Ref: TM-T62826
1mg70,00€5mg154,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€200mg1.026,00€1mL*10mM (DMSO)155,00€UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Formula:C18H17N3OPurezza:99.48%Colore e forma:SolidPeso molecolare:291.35Ref: TM-T88314
2mg38,00€5mg57,00€10mg92,00€25mg166,00€50mg254,00€100mg389,00€200mg566,00€1mL*10mM (DMSO)63,00€2,3-Bis(3-indolylmethyl)indole
CAS:2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.Formula:C26H21N3Colore e forma:SolidPeso molecolare:375.475Tripeptide-41
CAS:Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formula:C29H30N4O5Purezza:98%Colore e forma:SolidPeso molecolare:514.57ALPK1-IN-2
CAS:<p>ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).</p>Formula:C20H18F2N4O2SColore e forma:SolidPeso molecolare:416.44Ref: TM-T62162
Prodotto fuori produzioneALPK1-IN-1
CAS:<p>ALPK1-IN-1 (A001) strongly inhibits ALPK1, key for innate immunity & NF-κB signaling via TIFA/TRAF.</p>Formula:C25H32N6O2SColore e forma:SolidPeso molecolare:480.63Ref: TM-T63176
Prodotto fuori produzioneALPK1-IN-3
CAS:<p>ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced</p>Formula:C20H16F2N4OSPurezza:98%Colore e forma:SolidPeso molecolare:398.43
