NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 443 prodotti di "NF-κB"
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BAY32-5915
CAS:<p>BAY32-5915 is a selective inhibitor of IKKalpha.</p>Formula:C10H7NO3Purezza:96.48% - 97%Colore e forma:Yellow Crystalline PowderPeso molecolare:189.17DHMEQ racemate
CAS:<p>DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.</p>Formula:C13H11NO5Purezza:98%Colore e forma:SolidPeso molecolare:261.23HE 3286
CAS:<p>Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.</p>Formula:C21H30O3Colore e forma:SolidPeso molecolare:330.46IKK2-IN-4
CAS:<p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>Formula:C12H11N3O2SPurezza:>99.99%Colore e forma:SolidPeso molecolare:261.3RI-962
CAS:<p>RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.</p>Formula:C28H28N6O2Purezza:99.39%Colore e forma:SoildPeso molecolare:480.56NF-κB/PON1-IN-1
CAS:<p>NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.</p>Formula:C20H16N6O4S2Colore e forma:SolidPeso molecolare:468.51Anti-inflammatory agent 21
CAS:<p>Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.</p>Formula:C24H21FO6Colore e forma:SolidPeso molecolare:424.42Xanthine oxidase-IN-6
<p>Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.</p>Formula:C29H34N2O15Colore e forma:SolidPeso molecolare:650.58TNF-α-IN-18
CAS:<p>TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.</p>Formula:C16H7ClF2O4Purezza:99.77%Colore e forma:SolidPeso molecolare:336.67APC-0576
CAS:<p>APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.</p>Formula:C23H27N3O3Colore e forma:SolidPeso molecolare:393.48DMX-129
CAS:<p>DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].</p>Formula:C19H17FN8Colore e forma:SolidPeso molecolare:376.39IKKβ-IN-1
CAS:<p>IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).</p>Formula:C31H30N4O4SColore e forma:SolidPeso molecolare:554.66GSK319347A
CAS:<p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>Formula:C22H19N3O5S2Purezza:98.42%Colore e forma:SolidPeso molecolare:469.53IMD-ferulic
<p>IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.</p>Formula:C36H41N7O4Colore e forma:SolidPeso molecolare:635.76Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Formula:C31H42N2O3Purezza:99.13% - >99.99%Colore e forma:SolidPeso molecolare:490.68Gue1654
CAS:<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Formula:C23H17N3OS3Purezza:98.02% - 98.04%Colore e forma:SolidPeso molecolare:447.6NF-κB-IN-2
CAS:<p>NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.</p>Formula:C15H18O3Colore e forma:SolidPeso molecolare:246.3RIP2 Kinase Inhibitor 3
CAS:<p>RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.</p>Formula:C19H24N4O3SPurezza:99.32% - 99.52%Colore e forma:SolidPeso molecolare:388.48Ro 106-9920
CAS:Inhibitor of NF-κB activationFormula:C10H7N5OSPurezza:98%Colore e forma:SolidPeso molecolare:245.26HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formula:C19H16ClN3O3SPurezza:98.07% - 98.17%Colore e forma:SolidPeso molecolare:401.87Avenanthramide-C methyl ester
CAS:<p>Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).</p>Formula:C17H15NO6Colore e forma:SolidPeso molecolare:329.3Bay 65-1942 hydrochloride
CAS:<p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>Formula:C22H26ClN3O4Colore e forma:SolidPeso molecolare:431.91SZM679
<p>SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.</p>Formula:C27H18F5N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:591.51NF-κB-IN-11
CAS:<p>NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.</p>Formula:C19H18O5Purezza:98%Colore e forma:SolidPeso molecolare:326.34IMD-biphenylA
CAS:<p>IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immune</p>Formula:C35H33N5O2Purezza:98%Colore e forma:SolidPeso molecolare:555.67CAY10575
CAS:<p>CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.</p>Formula:C22H21N3O6S2Colore e forma:SolidPeso molecolare:487.55NF-κB-IN-8
CAS:<p>NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.</p>Formula:C24H21N3O3Purezza:98%Colore e forma:SolidPeso molecolare:399.44HS271
CAS:<p>HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).</p>Formula:C21H24F3N5O2Purezza:98.79%Colore e forma:SolidPeso molecolare:435.44GSK2983559 free acid
CAS:<p>GSK2983559 free acid selectively inhibits RIP2, reducing inflammatory cytokines in human bowel disease.</p>Formula:C21H23N4O7PS2Purezza:97.8700% - 98.61%Colore e forma:SolidPeso molecolare:538.53SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Formula:C14H5ClF9N3OPurezza:99.79%Colore e forma:SolidPeso molecolare:437.65NFATc1-IN-1
CAS:<p>NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.</p>Formula:C13H8F2INO2Purezza:99.64%Colore e forma:SolidPeso molecolare:375.11IRAK4-IN-20
CAS:<p>IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).</p>Formula:C22H25F3N4O3Purezza:98.09%Colore e forma:SolidPeso molecolare:450.45B022
CAS:<p>B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.</p>Formula:C19H16ClN5OSPurezza:99.74%Colore e forma:SolidPeso molecolare:397.88Zabedosertib
CAS:<p>Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.</p>Formula:C20H21F3N4O4SPurezza:98.54%Colore e forma:SolidPeso molecolare:470.47RIPK1-IN-9
CAS:<p>RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).</p>Formula:C26H25FN6O2Purezza:99.85%Colore e forma:SolidPeso molecolare:472.51Zharp2-1
CAS:<p>Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).</p>Formula:C19H18N3O2PSPurezza:99.41%Colore e forma:SolidPeso molecolare:383.4Glabrescone C
CAS:<p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>Formula:C19H22O7Colore e forma:SolidPeso molecolare:362.37Ginsenoside Rk1
CAS:<p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>Formula:C42H70O12Purezza:98.46% - 99.13%Colore e forma:SolidPeso molecolare:767TBK1-IN-1
CAS:<p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>Formula:C27H37N7O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:491.63PF-184
<p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.</p>Formula:C32H32ClFN6O4Colore e forma:SolidPeso molecolare:619.09Dimethoxycurcumin
CAS:Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Formula:C23H24O6Purezza:99.87%Colore e forma:SolidPeso molecolare:396.43WEHI-345
CAS:<p>WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.</p>Formula:C22H23N7OPurezza:>99.99%Colore e forma:SolidPeso molecolare:401.46GSK840
CAS:<p>GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase</p>Formula:C21H23N3O3Purezza:99.7%Colore e forma:SolidPeso molecolare:365.43PK68
CAS:<p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>Formula:C22H24N4O3SPurezza:98.09% - 99.64%Colore e forma:SolidPeso molecolare:424.52GGTI 2147
CAS:<p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>Formula:C28H30N4O3Purezza:98.69%Colore e forma:SolidPeso molecolare:470.56IR-Crizotinib
CAS:<p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>Formula:C53H57Cl2FIN7OPurezza:98%Colore e forma:SolidPeso molecolare:1024.88IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Formula:C22H26ClN3O4Purezza:98%Colore e forma:SolidPeso molecolare:431.91RIP1 kinase inhibitor 4
CAS:<p>RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].</p>Formula:C23H23N5Purezza:98%Colore e forma:SolidPeso molecolare:369.46IMD-biphenylC
CAS:<p>IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.</p>Formula:C35H33N5O3Purezza:98%Colore e forma:SolidPeso molecolare:571.67Bay 65-1942 (R form)
CAS:<p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>Formula:C22H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:395.45
