IκB/IKK
Il complesso IκB/IKK è un regolatore chiave della via di segnalazione NF-κB, che controlla l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione e nella sopravvivenza cellulare. Le proteine IκB inibiscono l'attività di NF-κB sequestrandolo nel citoplasma, mentre le IKK fosforilano IκB, portando alla sua degradazione e all'attivazione di NF-κB. La disregolazione della via IκB/IKK è legata a infiammazione cronica, cancro e malattie autoimmuni. Presso CymitQuimica, offriamo una selezione di modulatori IκB/IKK di alta qualità per supportare la tua ricerca in trasduzione del segnale, infiammazione e sviluppo terapeutico.
Trovati 59 prodotti di "IκB/IKK"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formula:C22H26N2O2Purezza:99.85% - 99.98%Colore e forma:White Crystalline SolidPeso molecolare:350.45Ac2-26 ammonium
Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.Formula:C141H210N32O44S·xNH3Purezza:95.58%Colore e forma:SolidPeso molecolare:3089.43 (free base)IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Formula:C15H8BrF6NO2Purezza:99.51%Colore e forma:SolidPeso molecolare:428.12BAY-985
CAS:BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formula:C27H30F3N9OPurezza:99.62%Colore e forma:SolidPeso molecolare:553.58Ref: TM-T10477
1mg172,00€5mg354,00€10mg567,00€25mg905,00€50mg1.225,00€100mg1.644,00€1mL*10mM (DMSO)430,00€TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Formula:C26H27N5O3Purezza:98.89%Colore e forma:SolidPeso molecolare:457.52Ref: TM-T15559
1mg92,00€5mg188,00€10mg305,00€25mg487,00€50mg660,00€100mg847,00€1mL*10mM (DMSO)188,00€IKK-IN-3
CAS:IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).Formula:C17H17N5SColore e forma:SolidPeso molecolare:323.42PS 1145 dihydrochloride
CAS:IκB kinase (IKK) inhibitorFormula:C17H13Cl3N4OPurezza:98%Colore e forma:SolidPeso molecolare:395.67HOIPIN-1
CAS:HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formula:C17H13NaO4Purezza:98.65%Colore e forma:SoildPeso molecolare:304.27LY2409881
CAS:LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.Formula:C24H29ClN6OSColore e forma:SolidPeso molecolare:485.05MRT67307
CAS:Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.Formula:C26H36N6O2Purezza:99.25% - 99.84%Colore e forma:SolidPeso molecolare:464.6SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Colore e forma:Odour SolidPROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI).Formula:C39H42Cl2N8O9Colore e forma:SolidPeso molecolare:836.24518Siegesbeckialide I
Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.Formula:C20H28O6Colore e forma:SolidPeso molecolare:364.43TBK1/IKKε-IN-6
CAS:TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.Formula:C31H36F2N8O4Colore e forma:SolidPeso molecolare:622.678Verproside
CAS:Verproside is a useful organic compound for research related to life sciences. The catalog number is T124745 and the CAS number is 50932-20-2.Formula:C22H26O13Colore e forma:SolidPeso molecolare:498.437IKK 16 hydrochloride
CAS:IKK 16 hydrochloride, a potent IKK1/2 and LRRK2 inhibitor, IC50s: 40-200 nM and 50 nM respectively.Formula:C28H30ClN5OSColore e forma:SolidPeso molecolare:520.09ML 120B dihydrochloride
CAS:MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.Formula:C19H17Cl3N4O2Colore e forma:SolidPeso molecolare:439.722-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:<p>2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.</p>Formula:C11H10N2OSPurezza:99.48%Colore e forma:SolidPeso molecolare:218.27AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Formula:C21H23N5O4SPurezza:98.98% - 99.17%Colore e forma:SolidPeso molecolare:441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€MLN120B
CAS:MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).Formula:C19H15ClN4O2Purezza:98.92%Colore e forma:SolidPeso molecolare:366.8Ref: TM-TQ0306
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg329,00€50mg567,00€100mg777,00€1mL*10mM (DMSO)116,00€
