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IκB/IKK

IκB/IKK

Il complesso IκB/IKK è un regolatore chiave della via di segnalazione NF-κB, che controlla l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione e nella sopravvivenza cellulare. Le proteine IκB inibiscono l'attività di NF-κB sequestrandolo nel citoplasma, mentre le IKK fosforilano IκB, portando alla sua degradazione e all'attivazione di NF-κB. La disregolazione della via IκB/IKK è legata a infiammazione cronica, cancro e malattie autoimmuni. Presso CymitQuimica, offriamo una selezione di modulatori IκB/IKK di alta qualità per supportare la tua ricerca in trasduzione del segnale, infiammazione e sviluppo terapeutico.

Trovati 59 prodotti di "IκB/IKK"

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  • INH14
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    INH14

    CAS:
    INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
    Formula:C15H16N2O
    Purezza:95.41%
    Colore e forma:Solid
    Peso molecolare:240.3

    Ref: TM-T5209

  • GSK8612
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    GSK8612

    CAS:
    GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .
    Formula:C17H17BrF3N7O2S
    Purezza:99.68% - 99.99%
    Colore e forma:Solid
    Peso molecolare:520.33

    Ref: TM-T5540

  • SC-514
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    SC-514

    CAS:
    <p>SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.</p>
    Formula:C9H8N2OS2
    Purezza:99.88% - >99.99%
    Colore e forma:Solid
    Peso molecolare:224.3

    Ref: TM-T2118

  • IMD-0354
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    IMD-0354

    CAS:
    IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.
    Formula:C15H8ClF6NO2
    Purezza:99.65% - 99.98%
    Colore e forma:Solid
    Peso molecolare:383.67

    Ref: TM-T6141

  • BOT-64
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    BOT-64

    CAS:
    BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole
    Formula:C15H15NO2S
    Purezza:99.73%
    Colore e forma:Solid
    Peso molecolare:273.35

    Ref: TM-T8705

  • JTP 0819958 - HOIPIN-1
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    JTP 0819958 - HOIPIN-1

    JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.
    Formula:C17H13NaO4
    Purezza:99.95%
    Colore e forma:Solid
    Peso molecolare:304.27

    Ref: TM-T8951

  • BMS-345541
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    BMS-345541

    CAS:
    BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
    Formula:C14H17N5
    Purezza:99.36% - 99.74%
    Colore e forma:Solid
    Peso molecolare:255.32

    Ref: TM-T6326

  • NF-κB-IN-1
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    NF-κB-IN-1

    CAS:
    NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway
    Formula:C31H30O8
    Purezza:99.03%
    Colore e forma:Solid
    Peso molecolare:530.57

    Ref: TM-T9105

  • BMS-345541 hydrochloride
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    BMS-345541 hydrochloride

    CAS:
    BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
    Formula:C14H18ClN5
    Purezza:99.13%
    Colore e forma:Solid
    Peso molecolare:291.78

    Ref: TM-T8542

  • GS143
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    GS143

    CAS:
    GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.
    Formula:C28H19FN2O4
    Purezza:97.67%
    Colore e forma:Solid
    Peso molecolare:466.46

    Ref: TM-T25465

  • TBK1/IKKε-IN-5
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    TBK1/IKKε-IN-5

    CAS:
    <p>TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).</p>
    Formula:C28H31N7O3
    Purezza:98.77%
    Colore e forma:Solid
    Peso molecolare:513.59

    Ref: TM-T7951

  • Ertiprotafib
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    Ertiprotafib

    CAS:
    <p>Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.</p>
    Formula:C31H27BrO3S
    Purezza:98.70%
    Colore e forma:Solid
    Peso molecolare:559.51

    Ref: TM-T15243

  • IKKβ-IN-1
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    IKKβ-IN-1

    CAS:
    IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).
    Formula:C31H30N4O4S
    Colore e forma:Solid
    Peso molecolare:554.66

    Ref: TM-T63919

  • Bay 65-1942 hydrochloride
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    Bay 65-1942 hydrochloride

    CAS:
    Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.
    Formula:C22H26ClN3O4
    Colore e forma:Solid
    Peso molecolare:431.91

    Ref: TM-T14508

  • 1-Dehydro-[10]-gingerdione
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    1-Dehydro-[10]-gingerdione

    CAS:
    <p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>
    Formula:C21H30O4
    Colore e forma:Solid
    Peso molecolare:346.46

    Ref: TM-T72208

  • PHA-408
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    PHA-408

    CAS:
    PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.
    Formula:C29H27ClFN7O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:560.02

    Ref: TM-T24629

  • GSK319347A
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    GSK319347A

    CAS:
    GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.
    Formula:C22H19N3O5S2
    Purezza:98.42%
    Colore e forma:Solid
    Peso molecolare:469.53

    Ref: TM-T15558

  • DMX-129
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    DMX-129

    CAS:
    DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].
    Formula:C19H17FN8
    Colore e forma:Solid
    Peso molecolare:376.39

    Ref: TM-T61550

  • IKK2-IN-4
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    IKK2-IN-4

    CAS:
    <p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>
    Formula:C12H11N3O2S
    Purezza:>99.99%
    Colore e forma:Solid
    Peso molecolare:261.3

    Ref: TM-T36524

  • CAY10575
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    CAY10575

    CAS:
    CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.
    Formula:C22H21N3O6S2
    Colore e forma:Solid
    Peso molecolare:487.55

    Ref: TM-T26957