IκB/IKK
Il complesso IκB/IKK è un regolatore chiave della via di segnalazione NF-κB, che controlla l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione e nella sopravvivenza cellulare. Le proteine IκB inibiscono l'attività di NF-κB sequestrandolo nel citoplasma, mentre le IKK fosforilano IκB, portando alla sua degradazione e all'attivazione di NF-κB. La disregolazione della via IκB/IKK è legata a infiammazione cronica, cancro e malattie autoimmuni. Presso CymitQuimica, offriamo una selezione di modulatori IκB/IKK di alta qualità per supportare la tua ricerca in trasduzione del segnale, infiammazione e sviluppo terapeutico.
Trovati 55 prodotti per "IκB/IKK".
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CGA-JK3
CAS:CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Formula:C15H19NO3Purezza:98%Colore e forma:SolidPeso molecolare:261.32(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formula:C27H30F3N9OPurezza:98%Colore e forma:SolidPeso molecolare:553.58Bay 65-1942 (R form)
CAS:Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.Formula:C22H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:395.45IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Formula:C22H26ClN3O4Purezza:98%Colore e forma:SolidPeso molecolare:431.91ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formula:C21H25ClN4O2Purezza:99.83%Colore e forma:SolidPeso molecolare:400.9Ref: TM-T10237
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg355,00€50mg512,00€100mg737,00€500mg1.468,00€IKK-IN-4
CAS:IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].Formula:C18H19N5SColore e forma:SolidPeso molecolare:337.44PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Formula:C29H27ClFN7O2Purezza:97.26%Colore e forma:SolidPeso molecolare:560.02Ref: TM-T24629
10mgPrezzo su richiesta1mg93,00€5mg197,00€1mL*10mM (DMSO)243,00€25mg520,00€50mg740,00€100mg982,00€PF-184
PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.Formula:C32H32ClFN6O4Colore e forma:SolidPeso molecolare:619.09TBK1-IN-1
CAS:TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formula:C27H37N7O2Purezza:99.81% - >99.99%Colore e forma:White SolidPeso molecolare:491.63Glabrescone C
CAS:Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.Formula:C19H22O7Colore e forma:SolidPeso molecolare:362.37Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formula:C22H20O12Colore e forma:SolidPeso molecolare:476.39(Z)-11,12-Epoxyeicosatrienoic acid
CAS:(Z)-11,12-Epoxyeicosatrienoic acid is a potent renal microvascular dilator with anti-inflammatory properties. It inhibits leukocyte adhesion to the vascular wall by suppressing the NF-κB pathway and IκB kinase (IKK) activity. This compound is useful in studies related to vascular inflammation.Formula:C20H32O3Peso molecolare:320.47TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formula:C28H26N4O5Purezza:98%Colore e forma:SolidPeso molecolare:498.53GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formula:C22H20O8Colore e forma:SolidPeso molecolare:412.39
