IκB/IKK

Il complesso IκB/IKK è un regolatore chiave della via di segnalazione NF-κB, che controlla l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione e nella sopravvivenza cellulare. Le proteine IκB inibiscono l'attività di NF-κB sequestrandolo nel citoplasma, mentre le IKK fosforilano IκB, portando alla sua degradazione e all'attivazione di NF-κB. La disregolazione della via IκB/IKK è legata a infiammazione cronica, cancro e malattie autoimmuni. Presso CymitQuimica, offriamo una selezione di modulatori IκB/IKK di alta qualità per supportare la tua ricerca in trasduzione del segnale, infiammazione e sviluppo terapeutico.

Trovati 59 prodotti di "IκB/IKK"

Purezza (%)

100

prodotti per pagina.

+ Info
CS12192
CAS:
- 1888318-68-0
CS12192 enhances survival, boosts weight, and shows promise in GVHD research per patent CN112773802A.
Formula:C₂₅H₂₃ClFN₇O₂
Colore e forma:Solid
Peso molecolare:507.95
Ref: TM-T63484
+ Info
HPN-01
CAS:
- 928655-63-4
HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.
Formula:C₁₉H₁₆ClN₃O₃S
Purezza:98.07% - 98.17%
Colore e forma:Solid
Peso molecolare:401.87
Ref: TM-T11573
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Bay 65-1942 free base
CAS:
- 600734-02-9
Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.
Formula:C₂₂H₂₅N₃O₄
Purezza:98%
Colore e forma:Solid
Peso molecolare:395.45
Ref: TM-T10472L
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TBK1/IKKε-IN-4
CAS:
- 1381930-17-1
TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM
Formula:C₂₈H₃₅N₇O₄
Colore e forma:Solid
Peso molecolare:533.62
Ref: TM-T38263
+ Info
BAY32-5915
CAS:
- 1571-30-8
BAY32-5915 is a selective inhibitor of IKKalpha.
Formula:C₁₀H₇NO₃
Purezza:96.48% - 97%
Colore e forma:Yellow Crystalline Powder
Peso molecolare:189.17
Ref: TM-T20770
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TBK1-IN-1
CAS:
- 3031785-78-8
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.
Formula:C₂₇H₃₇N₇O₂
Purezza:99.81% - >99.99%
Colore e forma:Solid
Peso molecolare:491.63
Ref: TM-T73322
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Glabrescone C
CAS:
- 2757214-13-2
Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.
Formula:C₁₉H₂₂O₇
Colore e forma:Solid
Peso molecolare:362.37
Ref: TM-T72899
+ Info
PF 184
CAS:
- 1187460-81-6
IKKβ inhibitor
Formula:C₃₂H₃₂ClFN₆O₄
Purezza:98%
Colore e forma:Solid
Peso molecolare:619.09
Ref: TM-T23137
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(Rac)-BAY-985
CAS:
- 2101925-20-4
(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.
Formula:C₂₇H₃₀F₃N₉O
Purezza:98%
Colore e forma:Solid
Peso molecolare:553.58
Ref: TM-T12659
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ACHP Hydrochloride
CAS:
- 406209-26-5
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.
Formula:C₂₁H₂₅ClN₄O₂
Purezza:99.83%
Colore e forma:Solid
Peso molecolare:400.9
Ref: TM-T10237
+ Info
IKK-IN-4
CAS:
- 615529-94-7
IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].
Formula:C₁₈H₁₉N₅S
Colore e forma:Solid
Peso molecolare:337.44
Ref: TM-T61059
+ Info
IKK-IN-1
CAS:
- 406211-06-1
IKK-IN-1 is an inhibitor of IKK.
Formula:C₂₂H₂₆ClN₃O₄
Purezza:98%
Colore e forma:Solid
Peso molecolare:431.91
Ref: TM-T11633
+ Info
CGA-JK3
CAS:
- 1621626-06-9
CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.
Formula:C₁₅H₁₉NO₃
Purezza:98%
Colore e forma:Solid
Peso molecolare:261.32
Ref: TM-T26989
+ Info
PF-184
PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.
Formula:C₃₂H₃₂ClFN₆O₄
Colore e forma:Solid
Peso molecolare:619.09
Ref: TM-T73470
+ Info
Bay 65-1942 (R form)
CAS:
- 758683-21-5
Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.
Formula:C₂₂H₂₅N₃O₄
Purezza:98%
Colore e forma:Solid
Peso molecolare:395.45
Ref: TM-T10472
+ Info
BMS-066
CAS:
- 914946-88-6
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
Formula:C₁₉H₂₁N₇O₂
Purezza:98%
Colore e forma:Solid
Peso molecolare:379.42
Ref: TM-T14669
+ Info
Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.
Formula:C₂₂H₂₀O₁₂
Colore e forma:Solid
Peso molecolare:476.39
Ref: TM-T63107
+ Info
GTCpFE
CAS:
- 1588866-45-8
GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.
Formula:C₂₂H₂₀O₈
Colore e forma:Solid
Peso molecolare:412.39
Ref: TM-T200141
+ Info
TBK1/IKKε-IN-1
CAS:
- 2058264-32-5
TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
Formula:C₂₈H₂₆N₄O₅
Purezza:98%
Colore e forma:Solid
Peso molecolare:498.53
Ref: TM-T13097

IκB/IKK

Trovati 59 prodotti di "IκB/IKK"

CS12192

Ref: TM-T63484

HPN-01

Ref: TM-T11573

Bay 65-1942 free base

Ref: TM-T10472L

TBK1/IKKε-IN-4

Ref: TM-T38263

BAY32-5915

Ref: TM-T20770

TBK1-IN-1

Ref: TM-T73322

Glabrescone C

Ref: TM-T72899

PF 184

Ref: TM-T23137

(Rac)-BAY-985

Ref: TM-T12659

ACHP Hydrochloride

Ref: TM-T10237

IKK-IN-4

Ref: TM-T61059

IKK-IN-1

Ref: TM-T11633

CGA-JK3

Ref: TM-T26989

PF-184

Ref: TM-T73470

Bay 65-1942 (R form)

Ref: TM-T10472

BMS-066

Ref: TM-T14669

Anti-inflammatory agent 6

Ref: TM-T63107

GTCpFE

Ref: TM-T200141

TBK1/IKKε-IN-1

Ref: TM-T13097