CCR
I recettori delle chemochine C-C (CCR) sono un gruppo di GPCR che rispondono alle chemochine, molecole segnalatrici che guidano la migrazione delle cellule immunitarie verso i siti di infiammazione o infezione. I CCR svolgono ruoli cruciali nelle risposte immunitarie, nell'infiammazione e nello sviluppo di varie malattie, tra cui disturbi autoimmuni e cancro. La modulazione dell'attività dei CCR è esplorata come strategia terapeutica per condizioni come l'artrite reumatoide, la sclerosi multipla e l'infezione da HIV. Presso CymitQuimica, offriamo una gamma di modulatori CCR di alta qualità per supportare la tua ricerca in immunologia, infiammazione e sviluppo terapeutico.
Trovati 136 prodotti di "CCR"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
PF-04634817
CAS:<p>PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.</p>Formula:C25H36F3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:511.58RP-23618
CAS:<p>RP-23618 is a non-peptidic antagonist of RANTES.</p>Formula:C30H35N5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:577.76VCH-286
CAS:<p>VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.</p>Formula:C34H50F2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:600.78SB-649701
CAS:<p>SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].</p>Formula:C27H28N4O3Purezza:98%Colore e forma:SolidPeso molecolare:456.54IPG7236
CAS:<p>IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer</p>Formula:C23H31N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:429.58(1S)-CCR2 antagonist 1
CAS:<p>(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].</p>Formula:C28H32BrF3N2OColore e forma:SolidPeso molecolare:549.47(Rac)-PF-4136309(1341224-83-6 Free base)
CAS:<p>PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for human</p>Formula:C29H31F3N6O3Colore e forma:SolidPeso molecolare:568.59PF-04634817 succinate
CAS:<p>PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.</p>Formula:C29H42F3N5O7Purezza:98%Colore e forma:SolidPeso molecolare:629.67MLN-3897
CAS:<p>MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.</p>Formula:C30H31ClN2O4Purezza:98.62%Colore e forma:SolidPeso molecolare:519.03AZD2423
CAS:<p>AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for</p>Formula:C20H29ClFN5O2Purezza:98%Colore e forma:SolidPeso molecolare:425.93LMD-009
CAS:<p>LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.</p>Formula:C29H33N3O3Purezza:98%Colore e forma:SolidPeso molecolare:471.59CMPD167
CAS:<p>CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].</p>Formula:C35H47FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:574.77CCR3 antagonist 1
CAS:<p>CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.</p>Formula:C19H21Cl2N3O4S2Purezza:98.28%Colore e forma:SolidPeso molecolare:490.42K777
CAS:<p>K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).</p>Formula:C32H38N4O4SPurezza:98.43% - 99.14%Colore e forma:SolidPeso molecolare:574.73INCB3344
CAS:<p>INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8</p>Formula:C29H34F3N3O6Purezza:98% - 98.2%Colore e forma:SolidPeso molecolare:577.59CP-481715
CAS:<p>CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.</p>Formula:C26H31FN4O4Colore e forma:SolidPeso molecolare:482.55CCR7 Ligand 1
CAS:<p>CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.</p>Formula:C22H29N5O5SColore e forma:SolidPeso molecolare:475.56CP-865569
CAS:<p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>Formula:C22H26ClFN2O5SColore e forma:SolidPeso molecolare:484.969MK-0812
CAS:<p>MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.</p>Formula:C24H34F3N3O3Purezza:98%Colore e forma:SolidPeso molecolare:469.54CCR1 antagonist 11 hydrochloride
<p>Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.</p>Colore e forma:SolidAplaviroc
CAS:<p>Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.</p>Formula:C33H43N3O6Purezza:97.98% - 98.26%Colore e forma:SolidPeso molecolare:577.71BMS-741672
CAS:<p>BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.</p>Formula:C25H33F3N6O2Colore e forma:SolidPeso molecolare:506.56Aplaviroc hydrochloride
CAS:<p>Aplaviroc, a potent CCR5 inhibitor, binds selectively, blocking HIV entry and specific monoclonal antibody attachment in vitro.</p>Formula:C33H44ClN3O6Colore e forma:SolidPeso molecolare:614.17INCB-9471 dihydrochloride
CAS:<p>INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.</p>Formula:C30H42Cl2F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:632.59BAY-3153
CAS:<p>BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .</p>Formula:C25H29Cl2N3O4Colore e forma:SolidPeso molecolare:506.42PF-07054894
CAS:<p>PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.</p>Formula:C24H30N6O4Colore e forma:SolidPeso molecolare:466.53TAK-661
CAS:<p>TAK-661 is an inhibitor of eosinophil chemotaxis (eosinophil chemotaxis) that significantly alleviates late-phase bronchoconstriction while inhibiting the proliferation of eosinophils in bronchoalveolar lavage (BAL) and their infiltration into the airway walls.</p>Formula:C13H21N5O3SColore e forma:SolidPeso molecolare:327.40BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Formula:C22H18FN5O3SPurezza:99.86%Colore e forma:SolidPeso molecolare:451.47CXCR2/CCR7 antagonist-1
CAS:<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Formula:C23H27N3O5Colore e forma:SolidPeso molecolare:425.48CCR5 antagonist 1
CAS:<p>CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.</p>Formula:C39H46ClF2N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:738.33Ophiobolin C
CAS:<p>inhibitor of human CCR5 binding to HIV-1 gp120</p>Formula:C25H38O3Purezza:98%Colore e forma:SolidPeso molecolare:386.57CCR1 antagonist 13
CAS:<p>CCR1 antagonist13 is a selective small molecule antagonist of CCR1.</p>Formula:C25H27ClFN3O4Colore e forma:SolidPeso molecolare:487.95Nifeviroc
CAS:<p>Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.</p>Formula:C33H42N4O6Purezza:98.14%Colore e forma:SolidPeso molecolare:590.71AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formula:C32H38F2N2O5S2Purezza:98.1%Colore e forma:SolidPeso molecolare:632.78GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Colore e forma:Odour LiquidBX471 hydrochloride
CAS:<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Formula:C21H25Cl2FN4O3Purezza:98%Colore e forma:SolidPeso molecolare:471.35
