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CCR

CCR

I recettori delle chemochine C-C (CCR) sono un gruppo di GPCR che rispondono alle chemochine, molecole segnalatrici che guidano la migrazione delle cellule immunitarie verso i siti di infiammazione o infezione. I CCR svolgono ruoli cruciali nelle risposte immunitarie, nell'infiammazione e nello sviluppo di varie malattie, tra cui disturbi autoimmuni e cancro. La modulazione dell'attività dei CCR è esplorata come strategia terapeutica per condizioni come l'artrite reumatoide, la sclerosi multipla e l'infezione da HIV. Presso CymitQuimica, offriamo una gamma di modulatori CCR di alta qualità per supportare la tua ricerca in immunologia, infiammazione e sviluppo terapeutico.

Trovati 136 prodotti di "CCR"

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prodotti per pagina.
  • PF-04634817
    Targetmol
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    PF-04634817

    CAS:
    <p>PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.</p>
    Formula:C25H36F3N5O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:511.58

    Ref: TM-T12419L

  • RP-23618
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    RP-23618

    CAS:
    <p>RP-23618 is a non-peptidic antagonist of RANTES.</p>
    Formula:C30H35N5O3S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:577.76

    Ref: TM-T24735

  • VCH-286
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    VCH-286

    CAS:
    <p>VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.</p>
    Formula:C34H50F2N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:600.78

    Ref: TM-T29100

  • SB-649701
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    SB-649701

    CAS:
    <p>SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].</p>
    Formula:C27H28N4O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:456.54

    Ref: TM-T79095

  • IPG7236
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    IPG7236

    CAS:
    <p>IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer</p>
    Formula:C23H31N3O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:429.58

    Ref: TM-T79096

  • (1S)-CCR2 antagonist 1
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    (1S)-CCR2 antagonist 1

    CAS:
    <p>(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].</p>
    Formula:C28H32BrF3N2O
    Colore e forma:Solid
    Peso molecolare:549.47

    Ref: TM-T84723

  • (Rac)-PF-4136309(1341224-83-6 Free base)
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    (Rac)-PF-4136309(1341224-83-6 Free base)

    CAS:
    <p>PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for human</p>
    Formula:C29H31F3N6O3
    Colore e forma:Solid
    Peso molecolare:568.59

    Ref: TM-T3430L

  • PF-04634817 succinate
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    PF-04634817 succinate

    CAS:
    <p>PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.</p>
    Formula:C29H42F3N5O7
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:629.67

    Ref: TM-T12419

  • MLN-3897
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    MLN-3897

    CAS:
    <p>MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.</p>
    Formula:C30H31ClN2O4
    Purezza:98.62%
    Colore e forma:Solid
    Peso molecolare:519.03

    Ref: TM-T28072

  • AZD2423
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    AZD2423

    CAS:
    <p>AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for</p>
    Formula:C20H29ClFN5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:425.93

    Ref: TM-T14373

  • LMD-009
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    LMD-009

    CAS:
    <p>LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.</p>
    Formula:C29H33N3O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:471.59

    Ref: TM-T11862

  • CMPD167
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    CMPD167

    CAS:
    <p>CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].</p>
    Formula:C35H47FN4O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:574.77

    Ref: TM-T82702

  • CCR3 antagonist 1
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    CCR3 antagonist 1

    CAS:
    <p>CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.</p>
    Formula:C19H21Cl2N3O4S2
    Purezza:98.28%
    Colore e forma:Solid
    Peso molecolare:490.42

    Ref: TM-T10156

  • K777
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    K777

    CAS:
    <p>K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50&lt;1 nM).</p>
    Formula:C32H38N4O4S
    Purezza:98.43% - 99.14%
    Colore e forma:Solid
    Peso molecolare:574.73

    Ref: TM-T15641

  • INCB3344
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    INCB3344

    CAS:
    <p>INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8</p>
    Formula:C29H34F3N3O6
    Purezza:98% - 98.2%
    Colore e forma:Solid
    Peso molecolare:577.59

    Ref: TM-TQ0103

  • CP-481715
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    CP-481715

    CAS:
    <p>CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.</p>
    Formula:C26H31FN4O4
    Colore e forma:Solid
    Peso molecolare:482.55

    Ref: TM-T31061

  • CCR7 Ligand 1
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    CCR7 Ligand 1

    CAS:
    <p>CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.</p>
    Formula:C22H29N5O5S
    Colore e forma:Solid
    Peso molecolare:475.56

    Ref: TM-T10716

  • CP-865569
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    CP-865569

    CAS:
    <p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>
    Formula:C22H26ClFN2O5S
    Colore e forma:Solid
    Peso molecolare:484.969

    Ref: TM-T206204

  • MK-0812
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    MK-0812

    CAS:
    <p>MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.</p>
    Formula:C24H34F3N3O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:469.54

    Ref: TM-TQ0182

  • Logo CymitQuimica
    Targetmol
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    CCR1 antagonist 11 hydrochloride

    <p>Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.</p>
    Colore e forma:Solid

    Ref: TM-T64242