CCR
I recettori delle chemochine C-C (CCR) sono un gruppo di GPCR che rispondono alle chemochine, molecole segnalatrici che guidano la migrazione delle cellule immunitarie verso i siti di infiammazione o infezione. I CCR svolgono ruoli cruciali nelle risposte immunitarie, nell'infiammazione e nello sviluppo di varie malattie, tra cui disturbi autoimmuni e cancro. La modulazione dell'attività dei CCR è esplorata come strategia terapeutica per condizioni come l'artrite reumatoide, la sclerosi multipla e l'infezione da HIV. Presso CymitQuimica, offriamo una gamma di modulatori CCR di alta qualità per supportare la tua ricerca in immunologia, infiammazione e sviluppo terapeutico.
Trovati 136 prodotti di "CCR"
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J-113863
CAS:<p>J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).</p>Formula:C30H37Cl2IN2O2Purezza:95.11%Colore e forma:SolidPeso molecolare:655.44Leronlimab
CAS:<p>Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.</p>Purezza:SDS-PAGE:95.0%;SEC-HPLC:99.6%Colore e forma:LiquidPeso molecolare:146.66 kDaRS102895 hydrochloride
CAS:<p>RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).</p>Formula:C21H22ClF3N2O2Purezza:98.95%Colore e forma:SolidPeso molecolare:426.86Mogamulizumab
CAS:<p>Mogamulizumab is a monoclonal antibody targeting CC chemokine receptor 4 with anticancer effects, used in ATLL and CTCL studies.</p>Purezza:SDS-PAGE:97.3%;SEC-HPLC:99.4%Colore e forma:LiquidPeso molecolare:146.43 kDaCCX140
CAS:<p>CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.</p>Formula:C20H13ClF3N5O3SPurezza:99.66% - 99.95%Colore e forma:SolidPeso molecolare:495.86MK-0812 Succinate
CAS:<p>MK-0812 Succinate is an effective and selective CCR2 antagonist.</p>Formula:C28H40F3N3O7Purezza:98.62% - 99.93%Colore e forma:SolidPeso molecolare:587.63AZ084
CAS:<p>AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.</p>Formula:C26H34N4O2Purezza:97.12%Colore e forma:SolidPeso molecolare:434.57CCR2-RA-[R]
CAS:<p>CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).</p>Formula:C18H19ClFNO3Purezza:99.7%Colore e forma:SolidPeso molecolare:351.8INCB-9471
CAS:<p>INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.</p>Formula:C30H40F3N5O2Purezza:98.80%Colore e forma:SolidPeso molecolare:559.666ML604086
CAS:<p>ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.</p>Formula:C27H32N4O4SPurezza:99.91%Colore e forma:SolidPeso molecolare:508.63Lanerkitug
<p>Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.</p>Colore e forma:Odour LiquidCCR8 agonist 1
<p>CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.</p>Formula:C22H29NO3Colore e forma:SolidPeso molecolare:355.47WAY-639418
CAS:<p>WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.</p>Formula:C17H16ClN5Purezza:99.62%Colore e forma:SolidPeso molecolare:325.8INCB3344 R-isomer
<p>INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.</p>Formula:C29H34F3N3O6Purezza:98%Colore e forma:SolidPeso molecolare:577.59Plozalizumab
CAS:<p>Plozalizumab (MLN-1202) is a humanized selective and potent anti-CCR2 antibody.Plozalizumab has antitumor activity.Plozalizumab is used in the study of</p>Purezza:96.4%Colore e forma:LiquidPeso molecolare:146.02 kDaNI-0701
<p>NI-0701 is a humanized antibody targeting CCL5/RANTES.</p>Purezza:95.4% (SDS-PAGE); 99.4% (SEC-HPLC) - 95.4% (SDS-PAGE); 99.4% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.5kDaCCR6 antagonist 2
<p>CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.</p>Formula:C19H24N4O4Colore e forma:SolidPeso molecolare:372.42Denrakibart
<p>Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.</p>Colore e forma:Odour LiquidCCR8 antagonist 1
CAS:<p>CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.</p>Formula:C26H29N3O5SPurezza:99.51%Colore e forma:SolidPeso molecolare:495.59BMS-753426
CAS:<p>BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .</p>Formula:C25H33F3N6O2Colore e forma:SolidPeso molecolare:506.574CKLF1-C27 TFA
<p>CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.</p>Formula:C153H244F3N39O39Colore e forma:SolidPeso molecolare:3310.8Denikitug
<p>Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.</p>Colore e forma:Odour LiquidBertilimumab
CAS:<p>Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].</p>Colore e forma:LiquidChemokine Inhibitor Library
<p>A unique collection of xnum chemokines or chemokine receptors targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidCHS-114
<p>CHS-114 (SRF-114) is a fully human IgG1 antibody targeting the (CCR8) receptor. It shows potential for research in head and neck squamous cell carcinoma (HNSCC). The isotype control for CHS-114 can be referred to as HumanIgG1kappa, Isotype Control.</p>Colore e forma:Odour LiquidCafelkibart
<p>Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Colore e forma:Odour LiquidCH-0076989
CAS:<p>CH-0076989 is a chemokine receptor CCR3 agonist.</p>Formula:C24H22Br2N2O2Colore e forma:SolidPeso molecolare:530.25INCB 3284 dimesylate
CAS:<p>INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.</p>Formula:C28H39F3N4O10S2Purezza:98%Colore e forma:SolidPeso molecolare:712.76CCR6 antagonist 1
CAS:<p>CCR6 antagonist 1 blocks CCL20/CCR6, aiding autoimmune and IBD research.</p>Formula:C17H12F3NO2Purezza:99.83%Colore e forma:SoildPeso molecolare:319.28Nebokitug
<p>Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Colore e forma:Odour LiquidCAP-100
<p>CAP-100 is a monoclonal antibody targeting CCR7. It neutralizes the ligand binding site and signaling of CCR7. This compound effectively inhibits migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples induced by CCR7. CAP-100 can mediate potent tumor cell killing through host immune mechanisms and exhibits favorable toxicity profiles in related hematopoietic cell subsets. It is involved in research on antitumor activity and diseases like chronic lymphocytic leukemia (CLL).</p>Colore e forma:Odour Liquid2-Methoxyhydroquinone
CAS:<p>2-Methoxyhydroquinone inhibits MAO-A and MAO-B and reduces TNF-α-induced CCL2 production, a precursor for synthesising the Hsp90 inhibitor Geldanamycin.</p>Formula:C7H8O3Purezza:98.25%Colore e forma:SolidPeso molecolare:140.14SQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formula:C22H26N4O5Colore e forma:SolidPeso molecolare:426.47CCR6 inhibitor 1
CAS:<p>CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.</p>Formula:C24H23F3N4O3SPurezza:99.89%Colore e forma:SolidPeso molecolare:504.52Met-RANTES,human,acetate
<p>Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.</p>Colore e forma:Odour SolidMaceneolignan H
CAS:<p>Maceneolignan H, a neolignane from Myristica fragrans, selectively blocks CCR3 (EC50=1.4μM) with allergy research potential.</p>Formula:C24H30O7Colore e forma:SolidPeso molecolare:430.49Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formula:C115H145ClN18O31S2Zn2Colore e forma:SolidPeso molecolare:2505.83CCR4 antagonist 3 hydrochloride
CAS:<p>Orally active CCR4 antagonist 3 hydrochloride with potent selectivity, IC50s: 22/50 nM; has antitumor properties.</p>Formula:C24H27Cl2N7O·xHClColore e forma:SolidAzirkitug
<p>Azirkitug is a humanized IgG1κ antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.</p>Colore e forma:Odour LiquidMLN-3897 TFA
<p>MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.</p>Formula:C32H32ClF3N2O6Purezza:98.62%Colore e forma:SolidPeso molecolare:633.05PF-232798
CAS:<p>PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.</p>Formula:C29H40FN5O2Colore e forma:SolidPeso molecolare:509.66CCR4 antagonist 3
CAS:<p>Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.</p>Formula:C24H27Cl2N7OColore e forma:SolidPeso molecolare:500.43CCR2 antagonist 1
CAS:<p>CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).</p>Formula:C28H32BrF3N2OColore e forma:SolidPeso molecolare:549.47AZD2098
CAS:AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.Formula:C11H9Cl2N3O3SPurezza:99.80% - >99.99%Colore e forma:SolidPeso molecolare:334.18Vercirnon
CAS:<p>Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.</p>Formula:C22H21ClN2O4SPurezza:99.23%Colore e forma:SolidPeso molecolare:444.93AZD-4818
CAS:<p>AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Formula:C27H32Cl2N2O7Purezza:99.01%Colore e forma:SolidPeso molecolare:567.46Vicriviroc maleate
CAS:<p>Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.</p>Formula:C32H42F3N5O6Purezza:98.16% - 98.37%Colore e forma:SolidPeso molecolare:649.7Cenicriviroc
CAS:<p>Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.</p>Formula:C41H52N4O4SPurezza:97.87%Colore e forma:SolidPeso molecolare:696.94Bindarit
CAS:<p>Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.</p>Formula:C19H20N2O3Purezza:98.35% - 98.55%Colore e forma:SolidPeso molecolare:324.37SB297006
CAS:<p>SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.</p>Formula:C18H18N2O5Purezza:99.59%Colore e forma:SolidPeso molecolare:342.35
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