CCR
I recettori delle chemochine C-C (CCR) sono un gruppo di GPCR che rispondono alle chemochine, molecole segnalatrici che guidano la migrazione delle cellule immunitarie verso i siti di infiammazione o infezione. I CCR svolgono ruoli cruciali nelle risposte immunitarie, nell'infiammazione e nello sviluppo di varie malattie, tra cui disturbi autoimmuni e cancro. La modulazione dell'attività dei CCR è esplorata come strategia terapeutica per condizioni come l'artrite reumatoide, la sclerosi multipla e l'infezione da HIV. Presso CymitQuimica, offriamo una gamma di modulatori CCR di alta qualità per supportare la tua ricerca in immunologia, infiammazione e sviluppo terapeutico.
Trovati 154 prodotti per "CCR".
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AZD-4818
CAS:AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.Formula:C27H32Cl2N2O7Purezza:99.01%Colore e forma:SolidPeso molecolare:567.46ZK 756326
CAS:ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.Formula:C21H28N2O3Purezza:99.43%Colore e forma:White SolidPeso molecolare:356.46PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Formula:C29H31F3N6O3Purezza:98.85% - 99.47%Colore e forma:SolidPeso molecolare:568.59RS102895
CAS:RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.Formula:C21H21F3N2O2Purezza:97.64% - 99.80%Colore e forma:SolidPeso molecolare:390.4Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Formula:C22H21ClN2O4SPurezza:99.23%Colore e forma:SolidPeso molecolare:444.93Ref: TM-T17225
1mg100,00€5mg245,00€1mL*10mM (DMSO)269,00€10mg385,00€25mg645,00€50mg888,00€100mg1.234,00€500mg2.457,00€Maraviroc
CAS:Maraviroc: a CCR5 antagonist blocking HIV-1 entry; IC50s—MIP-1α: 3.3nM, MIP-1β: 7.2nM, RANTES: 5.2nM.Formula:C29H41F2N5OPurezza:97.13% - 99.59%Colore e forma:SolidPeso molecolare:513.67Ref: TM-T6016
5mg49,00€1mL*10mM (DMSO)56,00€10mg90,00€25mg152,00€50mg259,00€100mg465,00€200mg600,00€500mg945,00€C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Formula:C27H41N5O2Purezza:99.74% - 99.90%Colore e forma:White SolidPeso molecolare:467.65Ref: TM-T21870
1mg49,00€2mg67,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg144,00€25mg286,00€50mg444,00€100mg622,00€RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Formula:C20H16Cl2N4Purezza:99.60% - 99.87%Colore e forma:White SolidPeso molecolare:383.27Vicriviroc maleate
CAS:Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.Formula:C32H42F3N5O6Purezza:98.16% - 98.37%Colore e forma:White SolidPeso molecolare:649.7CCR2 antagonist 4 hydrochloride
CAS:CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).Formula:C21H22Cl2F3N3O2Colore e forma:SolidPeso molecolare:476.327,4'-Dihydroxyflavone
CAS:7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.Formula:C15H10O4Purezza:99.39% - 99.6%Colore e forma:White SolidPeso molecolare:254.24Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Formula:C22H21ClN2NaO4SColore e forma:SolidPeso molecolare:467.92Cenicriviroc
CAS:Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.Formula:C41H52N4O4SPurezza:97.87%Colore e forma:Yellow SolidPeso molecolare:696.94Ref: TM-TQ0297
1mg63,00€2mg90,00€5mg133,00€1mL*10mM (DMSO)200,00€10mg212,00€25mg423,00€50mg550,00€100mg715,00€200mg964,00€AZD2098
CAS:AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.Formula:C11H9Cl2N3O3SPurezza:99.80% - 99.94%Colore e forma:SolidPeso molecolare:334.18Ref: TM-T4300
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg105,00€25mg217,00€50mg334,00€100mg502,00€500mg1.063,00€DAPTA
CAS:DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Formula:C35H56N10O15Purezza:>99.99%Colore e forma:White SolidPeso molecolare:856.88BMS-813160
CAS:BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.Formula:C25H40N8O2Purezza:99.66% - 99.79%Colore e forma:SolidPeso molecolare:484.64Ref: TM-T4584
1mg59,00€5mg130,00€1mL*10mM (DMSO)138,00€10mg177,00€25mg324,00€50mg537,00€100mg767,00€500mg1.558,00€RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Formula:C25H27N3O3Purezza:98.64% - 99.68%Colore e forma:SolidPeso molecolare:417.5Vicriviroc
CAS:Vicriviroc, also known as MK4176 is a CCR5 antagonist.Formula:C28H38F3N5O2Colore e forma:SolidPeso molecolare:533.63Bindarit
CAS:Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.Formula:C19H20N2O3Purezza:98.35% - 98.55%Colore e forma:SolidPeso molecolare:324.37Ref: TM-T6413
1mg35,00€2mg50,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg178,00€50mg314,00€100mg492,00€200mg710,00€SB297006
CAS:SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Formula:C18H18N2O5Purezza:99.59%Colore e forma:White SolidPeso molecolare:342.35BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Formula:C21H24ClFN4O3Purezza:98% - 99.98%Colore e forma:SolidPeso molecolare:434.89Ref: TM-T2375
1mg35,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg117,00€25mg200,00€50mg313,00€100mg489,00€200mg740,00€R243
CAS:R243 is CCR8 signaling and chemotaxis inhibitor.Formula:C21H27NO4Purezza:99.03% - 99.16%Colore e forma:Yellow SolidPeso molecolare:357.44Ref: TM-T24700
1mg40,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)90,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formula:C33H39ClN2O2Purezza:99.21%Colore e forma:SolidPeso molecolare:531.13INCB 3284
CAS:INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.Formula:C26H31F3N4O4Purezza:97.81% - 99.46%Colore e forma:SolidPeso molecolare:520.54Carlumab
CAS:Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.Purezza:95%Colore e forma:Transparent LiquidPeso molecolare:144.87 kDaAnti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is a monoclonal antibody targeting mouse/human/rat CCL2/MCP-1, capable of blocking the CCL2 signalling pathway.Purezza:99% - 99%Colore e forma:Transparent LiquidPeso molecolare:150 kDaTivumecirnon
CAS:Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumourFormula:C24H27Cl2F3N6OPurezza:99.88%Colore e forma:SolidPeso molecolare:543.41Ref: TM-T69834
1mg158,00€5mg385,00€1mL*10mM (DMSO)462,00€10mg625,00€25mg1.251,00€50mg2.008,00€100mg2.790,00€Lanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidDenikitug
Denikitug is a chimeric antibody of the IgG1κ type that targets CCR8, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidDenrakibart
Denrakibart is a humanized IgG2κ antibody targeting CCL17, with HumanIgG2kappa, Isotype Control serving as the corresponding isotype control.Colore e forma:Odour LiquidAzirkitug
Azirkitug is a humanized IgG1κ antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidCafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Colore e forma:Odour LiquidYM022
CAS:YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.Formula:C32H28N4O3Purezza:98%Colore e forma:SolidPeso molecolare:516.59TAK-220
CAS:TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).Formula:C31H41ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:553.14CCR1 antagonist 7
CAS:CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Formula:C21H24ClN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:461.96CCR1 antagonist 9
CAS:CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.Formula:C20H16FN5O3SPurezza:99.13%Colore e forma:SolidPeso molecolare:425.44Ref: TM-T10710
1mg94,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg371,00€25mg682,00€50mg982,00€100mg1.431,00€AZ760
CAS:AZ760 is a CCR8 antagonist that demonstrates excellent potency, good lipophilicity, and a high free fraction in blood, but exhibits unacceptable hERG inhibition [1].Formula:C29H33N3O4Peso molecolare:487.59GW 766994
CAS:GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.Formula:C21H24Cl2N4O3Purezza:98.77%Colore e forma:White SolidPeso molecolare:451.35CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Formula:C22H22ClN7O2Purezza:99.43% - 99.44%Colore e forma:SolidPeso molecolare:451.91BMS-457
CAS:BMS-457 is a potent, CCR1-selective antagonist.Formula:C24H35ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:451PNU-177864 hydrochloride
CAS:PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.Formula:C18H22ClF3N2O3SPurezza:99.95%Colore e forma:SolidPeso molecolare:438.89PNU-177864
CAS:PNU-177864 is a selective dopamine D3 receptor antagonist.Formula:C18H21F3N2O3SPurezza:99.92%Colore e forma:SolidPeso molecolare:402.43RPT193
CAS:RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.Formula:C27H34Cl3N5O2Colore e forma:SolidPeso molecolare:566.95JNJ-27141491
CAS:JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Formula:C17H15F2N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:379.38CCR4 antagonist 3-1
CAS:CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.Formula:C14H12N2SPurezza:99.87%Colore e forma:SolidPeso molecolare:240.32MLN3126
CAS:MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.Formula:C21H19ClN2O5SColore e forma:SolidPeso molecolare:446.9CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Formula:C17H25FN2O2Purezza:99.87%Colore e forma:SolidPeso molecolare:308.39Ref: TM-T10712
1mg66,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg225,00€25mg398,00€50mg532,00€100mg745,00€200mg982,00€C-021 dihydrochloride
CAS:C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.Formula:C27H43Cl2N5O2Purezza:98.67%Colore e forma:White SolidPeso molecolare:540.57APC-3316 tosylate
CAS:APC-3316 tosylate is a vinyl sulfone cysteine protease inhibitor and selective CCR4 antagonist.Formula:C39H46N4O7S2Colore e forma:SolidPeso molecolare:746.94
