CCR
I recettori delle chemochine C-C (CCR) sono un gruppo di GPCR che rispondono alle chemochine, molecole segnalatrici che guidano la migrazione delle cellule immunitarie verso i siti di infiammazione o infezione. I CCR svolgono ruoli cruciali nelle risposte immunitarie, nell'infiammazione e nello sviluppo di varie malattie, tra cui disturbi autoimmuni e cancro. La modulazione dell'attività dei CCR è esplorata come strategia terapeutica per condizioni come l'artrite reumatoide, la sclerosi multipla e l'infezione da HIV. Presso CymitQuimica, offriamo una gamma di modulatori CCR di alta qualità per supportare la tua ricerca in immunologia, infiammazione e sviluppo terapeutico.
Trovati 136 prodotti di "CCR"
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RE-640
CAS:<p>NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.</p>Formula:C20H16Cl2N4Purezza:99.60% - 99.87%Colore e forma:SolidPeso molecolare:383.27BX471
CAS:<p>BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.</p>Formula:C21H24ClFN4O3Purezza:98% - 99.94%Colore e forma:SolidPeso molecolare:434.89AZD-4818
CAS:<p>AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.</p>Formula:C27H32Cl2N2O7Purezza:99.01%Colore e forma:SolidPeso molecolare:567.46Vicriviroc maleate
CAS:<p>Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.</p>Formula:C32H42F3N5O6Purezza:98.16% - 98.37%Colore e forma:SolidPeso molecolare:649.7CCR2 antagonist 4 hydrochloride
CAS:CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM).Formula:C21H22Cl2F3N3O2Colore e forma:SolidPeso molecolare:476.32RS102895
CAS:<p>RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.</p>Formula:C21H21F3N2O2Purezza:97.64% - 99.80%Colore e forma:SolidPeso molecolare:390.4SB297006
CAS:<p>SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.</p>Formula:C18H18N2O5Purezza:99.59%Colore e forma:SolidPeso molecolare:342.35Bindarit
CAS:<p>Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.</p>Formula:C19H20N2O3Purezza:98.35% - 98.55%Colore e forma:SolidPeso molecolare:324.377,4'-Dihydroxyflavone
CAS:<p>7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.</p>Formula:C15H10O4Purezza:99.39% - 99.6%Colore e forma:SolidPeso molecolare:254.24RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Formula:C25H27N3O3Purezza:98.64% - 99.62%Colore e forma:SolidPeso molecolare:417.5PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Formula:C29H31F3N6O3Purezza:98.85% - 99.47%Colore e forma:SolidPeso molecolare:568.59Vercirnon sodium
CAS:Vercirnon (GSK1605786A) sodium: oral CCR9 antagonist, inhibits Ca2+ mobilization/chemotaxis, IC50 = 2.6-5.4 nM, selective for CCR9 vs. CCR1-12/CX3CR1-7.Formula:C22H21ClN2NaO4SColore e forma:SolidPeso molecolare:467.92TAK-779
CAS:<p>TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).</p>Formula:C33H39ClN2O2Purezza:99.21%Colore e forma:SolidPeso molecolare:531.13Cenicriviroc
CAS:<p>Cenicriviroc (TAK-652), oral CCR2/CCR5 blocker, inhibits HIV-1/HIV-2, with strong anti-infective/anti-inflammatory effects.</p>Formula:C41H52N4O4SPurezza:97.87%Colore e forma:SolidPeso molecolare:696.94ZK 756326
CAS:<p>ZK 756326: Selective CCR8 agonist, IC50 1.8 μM (human), 2.6 μM (mouse), no CCR4/5, CXCR3/4 action, 28-fold selectivity vs 26 GPCRs, anti-HIV fusion.</p>Formula:C21H28N2O3Purezza:99.43%Colore e forma:SolidPeso molecolare:356.46INCB 3284
CAS:INCB 3284, a potent human CCR2 antagonist with an IC50 of 3.7 nM, is researchable for acute liver failure and inhibits MCP-1/hCCR2 binding.Formula:C26H31F3N4O4Purezza:97.81% - 99.42%Colore e forma:SolidPeso molecolare:520.54Carlumab
CAS:<p>Carlumab is a high-affinity human monoclonal antibody that targets CCL2, suppressing the recruitment of monocytes/macrophages in the tumour microenvironment.</p>Purezza:95%Colore e forma:LiquidTivumecirnon
CAS:<p>Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour</p>Formula:C24H27Cl2F3N6OPurezza:99.88%Colore e forma:SolidPeso molecolare:543.41CCR8 antagonist 2
CAS:<p>CCR8 antagonist 2 blocks CCR8 activity, mainly on Treg and Th2 cells, for treating related diseases. See WO2022000443A1, compound 220.</p>Formula:C23H30ClN3O3SColore e forma:SolidPeso molecolare:464.02JNJ-27141491
CAS:<p>JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.</p>Formula:C17H15F2N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:379.38BI-6901
CAS:<p>BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.</p>Formula:C23H27N5O3SPurezza:99.83%Colore e forma:SolidPeso molecolare:453.56PNU-177864
CAS:<p>PNU-177864 is a selective dopamine D3 receptor antagonist.</p>Formula:C18H21F3N2O3SPurezza:99.92%Colore e forma:SolidPeso molecolare:402.43GW 766994
CAS:<p>GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.</p>Formula:C21H24Cl2N4O3Purezza:98.77%Colore e forma:SolidPeso molecolare:451.35MLN3126
CAS:<p>MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.</p>Formula:C21H19ClN2O5SColore e forma:SolidPeso molecolare:446.9CCR1 antagonist 7
CAS:<p>CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].</p>Formula:C21H24ClN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:461.96TAK-220
CAS:TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).Formula:C31H41ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:553.14CCX354
CAS:<p>CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.</p>Formula:C22H22ClN7O2Purezza:99.82% - 99.82%Colore e forma:SolidPeso molecolare:451.91BMS-457
CAS:<p>BMS-457 is a potent, CCR1-selective antagonist.</p>Formula:C24H35ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:451C-021 dihydrochloride
CAS:<p>C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.</p>Formula:C27H43Cl2N5O2Purezza:98.67%Colore e forma:SolidPeso molecolare:540.57CCR4 antagonist 3-1
CAS:<p>CCR4 antagonist 3-1 is a weak inhibitor of [125I]TARC binding and CEM cell migration, with IC50 values of 1.7 μM and 6.4 μM, respectively.</p>Formula:C14H12N2SPurezza:99.53%Colore e forma:SolidPeso molecolare:240.32CCR1 antagonist 9
CAS:<p>CCR1 antagonist 9 (compound 19e) is a selective CCR1 antagonist based on aziridine. CCR1 inhibition in calcium flux assays.</p>Formula:C20H16FN5O3SPurezza:99.13%Colore e forma:SolidPeso molecolare:425.44CCR2 antagonist 3
CAS:<p>CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.</p>Formula:C17H25FN2O2Purezza:99.87%Colore e forma:SolidPeso molecolare:308.39RPT193
CAS:RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.Formula:C27H34Cl3N5O2Colore e forma:SolidPeso molecolare:566.95ALK4290
CAS:<p>ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.</p>Formula:C27H34ClN5O3Colore e forma:SolidPeso molecolare:512.04AZD-1678
CAS:<p>AZD-1678 is a potent CCR4 receptor antagonist.</p>Formula:C11H8Cl2FN3O3SColore e forma:SolidPeso molecolare:352.17YM022
CAS:<p>YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist.</p>Formula:C32H28N4O3Purezza:98%Colore e forma:SolidPeso molecolare:516.59PNU-177864 hydrochloride
CAS:<p>PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.</p>Formula:C18H22ClF3N2O3SPurezza:99.95%Colore e forma:SolidPeso molecolare:438.89CCR2 antagonist 5
CAS:<p>JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.</p>Formula:C22H25F3N4O3SPurezza:99.09%Colore e forma:SolidPeso molecolare:482.52Cosalane
CAS:<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Formula:C45H60Cl2O6Purezza:99.53% - 99.78%Colore e forma:SolidPeso molecolare:767.86SB 328437
CAS:<p>SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).</p>Formula:C21H18N2O5Purezza:99.54%Colore e forma:SolidPeso molecolare:378.38BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Formula:C28H34F3N5O4SPurezza:99.65%Colore e forma:SolidPeso molecolare:593.66CCR1 antagonist 6
CAS:<p>CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).</p>Formula:C21H23ClN4O3SPurezza:99.02% - 99.15%Colore e forma:SolidPeso molecolare:446.95GSK2239633A
CAS:<p>GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.</p>Formula:C24H25ClN4O5S2Purezza:99.82%Colore e forma:SolidPeso molecolare:549.06BMS-817399
CAS:<p>BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.</p>Formula:C23H36ClN3O4Purezza:99.7%Colore e forma:SolidPeso molecolare:454Ancriviroc
CAS:<p>Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.</p>Formula:C28H37BrN4O3Purezza:99.76% - 99.82%Colore e forma:SolidPeso molecolare:557.52trans-J-113863
CAS:<p>Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].</p>Formula:C30H37Cl2IN2O2Colore e forma:SolidPeso molecolare:655.44cis-J-113863
CAS:<p>Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].</p>Formula:C30H37Cl2IN2O2Colore e forma:SolidPeso molecolare:655.44CCR4 antagonist 4
CAS:<p>CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].</p>Formula:C24H27Cl2N7OColore e forma:SolidPeso molecolare:500.42BMS-639623
CAS:<p>BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.</p>Formula:C25H32FN7O2Colore e forma:SolidPeso molecolare:481.57CCR2 antagonist 4
CAS:<p>CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM</p>Formula:C21H21ClF3N3O2Purezza:99.86%Colore e forma:SolidPeso molecolare:439.86
