Nrf2
Nrf2 è un fattore di trascrizione che regola l'espressione di proteine antiossidanti ed enzimi di detossificazione, svolgendo un ruolo fondamentale nella difesa cellulare contro lo stress ossidativo e l'infiammazione. L'attivazione della segnalazione Nrf2 fornisce protezione contro varie malattie, tra cui il cancro, la neurodegenerazione e i disturbi cardiovascolari. I modulatori di Nrf2 sono oggetto di studio per le loro potenziali applicazioni terapeutiche nella riduzione dei danni ossidativi e dell'infiammazione. Presso CymitQuimica, offriamo una gamma di modulatori della via Nrf2 di alta qualità per supportare la tua ricerca sullo stress ossidativo, l'infiammazione e la prevenzione delle malattie.
Trovati 78 prodotti di "Nrf2"
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NK-252
CAS:<p>NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.</p>Formula:C13H11N5O3Purezza:98.32%Colore e forma:SolidPeso molecolare:285.26AA147
CAS:<p>AA147 is an ER proteostasis regulator that selectively activates the ATF6 arm of UPR as a prodrug.</p>Formula:C16H17NO2Purezza:99.24%Colore e forma:SolidPeso molecolare:255.31(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formula:C22H23NOPurezza:99.94%Colore e forma:SolidPeso molecolare:317.42BPK-29 hydrochloride
CAS:<p>"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."</p>Formula:C26H33Cl2N3O3Purezza:99.06%Colore e forma:SolidPeso molecolare:506.46Ezetimibe
CAS:<p>Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.</p>Formula:C24H21F2NO3Purezza:97.28% - 99.77%Colore e forma:SolidPeso molecolare:409.43Fraxinellone analog 1
<p>Fraxinellone analog 1 (compound 2) is an effective and rapid activator of the Nrf2-mediated antioxidative defense system, providing protection against glutamate-mediated excitotoxicity. It induces the expression of antioxidative genes Gpx4, Sod1, and Nqo1. Additionally, Fraxinellone analog 1 exerts neuroprotective effects and modulates oxidative stress and inflammation, making it suitable for research on neurodegenerative diseases.</p>Colore e forma:Odour SolidNrf2 activator 18
<p>Nrf2 activator 18 (Compound 11a) is an orally active activator of the Keap1/Nrf2/HO-1 signaling pathway, promoting Nrf2 nuclear translocation and enhancing antioxidant effects. It inhibits IL-6 release with an IC50 of 4.816 μM. In a mouse model of PM2.5-induced lung injury, Nrf2 activator 18 demonstrates anti-inflammatory activity.</p>Formula:C23H24FN3OColore e forma:SolidPeso molecolare:377.45TPNA10168
CAS:<p>Compound Fr13590, with CAS No. 957942-34-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13590 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formula:C9H9ClO2S2Colore e forma:SolidPeso molecolare:248.75His-Pro
CAS:<p>His-Pro is a dipeptide consisting of histidyl and proline.</p>Formula:C11H16N4O3Purezza:98%Colore e forma:SolidPeso molecolare:252.27Nrf2 activator-1
CAS:<p>Nrf2 activator-1 activates Nrf2; used for COPD, asthma, ALI, ARDS, pulmonary fibrosis research.</p>Formula:C30H34N4O6SPurezza:97.8%Colore e forma:SolidPeso molecolare:578.68Nrf2/HO-1 activator 3
<p>Nrf2/HO-1 Activator 3 (Compound C3a) is an activator of the Nrf2 signaling pathway that facilitates the translocation of Nrf2 into the nucleus and enhances the expression of heme oxygenase-1 (HO-1). In H9c2 cardiomyocytes subjected to H2O2 or high glucose stimulation, Nrf2/HO-1 Activator 3 inhibits the excessive expression of ROS and MDA, suppressing cell viability and colony formation, thereby exhibiting antioxidant activity.</p>Formula:C27H26N2O6Colore e forma:SolidPeso molecolare:474.51Butan-1-amine hydrochloride
CAS:<p>1-Butylamine hydrochloride,butylamine, a potential agonist of Nrf2/ARE (Nuclear Factor Erythroid 2 Associated Factor 2/Antioxidant Response Element).</p>Formula:C4H12ClNColore e forma:SolidPeso molecolare:109.6Keap1/Nrf2/ARE activator 1
<p>Keap1/Nrf2/ARE activator 1 (compound HT-3) functions as an activator of the Keap1/Nrf2/ARE pathway. This compound has antioxidant properties and offers neuroprotective effects.</p>Formula:C19H20O6Colore e forma:SolidPeso molecolare:344.12599Eriodictyol-7-O-glucoside
CAS:<p>Eriodictyol-7-O-glucoside, a flavonoid in pistachio skin, activates Nrf2 and protects against Cisplatin toxicity.</p>Formula:C21H22O11Purezza:99.53%Colore e forma:SolidPeso molecolare:450.39Nrf2 activator-8
<p>Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties</p>Formula:C13H11ClN2O3SColore e forma:SolidPeso molecolare:310.76Nrf2 degrader 1
CAS:<p>Nrf2 degrader 1 (compound 1), a PROTAC Nrf2 degrader, exhibits anticancer properties by inhibiting the growth of cancer cells. It demonstrates IC 50 values of 100 nM for A549 cells and 40 nM for LK-2 cells, indicating potent efficacy [1].</p>Formula:C45H42N6O8SColore e forma:SolidPeso molecolare:826.92Ac-LDEETGEFL-NH2
CAS:<p>Ac-LDEETGEFL-NH2 is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor</p>Formula:C48H72N10O19Colore e forma:SolidPeso molecolare:1093.144-P-PDOT
CAS:<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Formula:C19H21NOPurezza:99.91%Colore e forma:SolidPeso molecolare:279.3817-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Formula:C22H30O3Colore e forma:SolidPeso molecolare:342.479Pterisolic acid B
<p>Pterisolic acid B is a useful organic compound for research related to life sciences and the catalog number is T125924.</p>Formula:C20H26O4Colore e forma:SolidPeso molecolare:330.424TAT 14
CAS:<p>TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.</p>Formula:C137H230N48O39Purezza:98%Colore e forma:SolidPeso molecolare:3173.59S217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Formula:C29H30N4O7SColore e forma:SolidPeso molecolare:578.64Keap1-Nrf2-IN-9
CAS:<p>Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.</p>Formula:C31H30N2O11S2Colore e forma:SolidPeso molecolare:670.71Deacetylgedunin
CAS:<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Formula:C26H32O6Colore e forma:SolidPeso molecolare:440.53Anticonvulsant agent 10
<p>Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.</p>Colore e forma:Odour SolidKeap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formula:C17H21Cl2N2O5PS3Colore e forma:SolidPeso molecolare:531.434Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Formula:C31H34N6O3Colore e forma:SolidPeso molecolare:538.652Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Colore e forma:Odour SolidMonascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formula:C21H26O5Purezza:98%Colore e forma:SolidPeso molecolare:358.43CBR-470-2
CAS:<p>CBR-470-2 activates NRF2 signaling, aiding in glycolysis research.</p>Formula:C12H13Cl2NO6S2Colore e forma:SolidPeso molecolare:402.26KI696 isomer
CAS:<p>KI696 isomer is an isomer of KI696, a low affinity probe for the study of immune and metabolic diseases.</p>Formula:C28H30N4O6SPurezza:99.8%Colore e forma:SolidPeso molecolare:550.63ML334
CAS:<p>ML334 (LH601A) is an NRF2 activator that inhibits cardiac fibroblast activation and proliferation ameliorating myocardial infarction-induced cardiac fibrosis.</p>Formula:C26H26N2O5Purezza:98.06% - 98.06%Colore e forma:SolidPeso molecolare:446.49I-152
CAS:<p>Bepranemab (UCB 0107) is a humanized IgG monoclonal antibody against tau for the study of Alzheimer's disease (AD) and tau proteinopathies.</p>Formula:C9H16N2O3S2Purezza:98.36%Colore e forma:SolidPeso molecolare:264.37Anti-NFE2L2 Antibody (9K94)
<p>Anti-NFE2L2 Antibody (9K94) is a Mouse antibody targeting NFE2L2. Anti-NFE2L2 Antibody (9K94) can be used in ELISA, WB, IHC, IF, FCM.</p>Purezza:>95%Colore e forma:Odour LiquidAnti-Phospho-NFE2L2 (Ser40) Antibody (6V851)
<p>Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) is an antibody targeting Phospho-NFE2L2 (Ser40). Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) can be used in ELISA, WB, IHC, IF.</p>Colore e forma:Odour LiquidAnti-NFE2L2 Antibody (6K859)
<p>Anti-NFE2L2 Antibody (6K859) is an antibody targeting NFE2L2. Anti-NFE2L2 Antibody (6K859) can be used in ELISA, IF.</p>Colore e forma:Odour LiquidDimethyl fumarate-d6
CAS:<p>Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. can induces upregulation of antioxidant gene expression.</p>Formula:C6H8O4Purezza:98%Colore e forma:SolidPeso molecolare:150.16Artemisitene
CAS:<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Formula:C15H20O5Purezza:99.58%Colore e forma:SolidPeso molecolare:280.32AEM1
CAS:<p>AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.</p>Formula:C20H14FN3O2SPurezza:98.37% - 99.88%Colore e forma:SolidPeso molecolare:379.41ML162
CAS:<p>ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity. Cost-effective and quality-assured.</p>Formula:C23H22Cl2N2O3SPurezza:98.42% - 99.55%Colore e forma:SolidPeso molecolare:477.4Diroximel fumarate
CAS:<p>Diroximel fumarate (Diroximel Fumarete), a prodrug of monomethyl fumarate in a controlled-release formulation, rapidly and potently converts to MMF in the body.</p>Formula:C11H13NO6Purezza:99.8% - 99.88%Colore e forma:SolidPeso molecolare:255.22Trilobatin
CAS:<p>Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially</p>Formula:C21H24O10Purezza:97.16%Colore e forma:SolidPeso molecolare:436.414-Octyl itaconate
CAS:<p>4-Octyl Itaconate is a cell-permeable derivative of Itaconate, an anti-inflammatory metabolite.</p>Formula:C13H22O4Purezza:99.3% - 99.94%Colore e forma:SolidPeso molecolare:242.31Kinsenoside
CAS:<p>Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities.</p>Formula:C10H16O8Purezza:99.2% - >99.99%Colore e forma:SolidPeso molecolare:264.23Brusatol
CAS:<p>Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.</p>Formula:C26H32O11Purezza:99.35% - 99.95%Colore e forma:SolidPeso molecolare:520.53CBR-470-1
CAS:<p>CBR-470-1 is a glycolytic phosphoglycerate kinase 1 inhibitor and Nrf2 activator that exhibits neuroprotective activity by activating the Keap1-Nrf2 cascade.</p>Formula:C14H20ClNO4S2Purezza:98.87%Colore e forma:SolidPeso molecolare:365.9L-Cystine dihydrochloride
CAS:<p>L-Cystine dihydrochloride, a sulfur-based glutathione precursor, maintains GSH balance, used in cell culture.</p>Formula:C6H14Cl2N2O4S2Purezza:99.58%Colore e forma:SolidPeso molecolare:313.22MIND4-17
CAS:<p>MIND4-17 activates NRF2 by binding Keap1 C151, blocking Keap1-Nrf2, stabilizes Nrf2, and promotes its nuclear entry, with strong antioxidant effects.</p>Formula:C20H15N5O3SColore e forma:SolidPeso molecolare:405.43Nrf2-Activator-12G
CAS:<p>Nrf2-Activator-12G is a potent Nrf-2 activator.</p>Formula:C15H13ClO3SPurezza:98%Colore e forma:SolidPeso molecolare:308.78MSU38225
CAS:<p>MSU38225, an Nrf-2 inhibitor, elevates reactive oxygen species (ROS) levels and suppresses the proliferation of human lung cancer cells.</p>Formula:C21H19N3Colore e forma:SolidPeso molecolare:313.4(+)-DHMEQ
CAS:<p>(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.</p>Formula:C13H11NO5Colore e forma:SolidPeso molecolare:261.23Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Formula:C8H16O2S2Purezza:97.51%Colore e forma:Yellow To Orange LiquidPeso molecolare:208.34Keap1-Nrf2-IN-12
CAS:<p>eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.</p>Formula:C26H28N2O10S2Colore e forma:SolidPeso molecolare:592.64Keap1-Nrf2-IN-13
CAS:<p>Keap1-Nrf2-IN-13 is a PPI inhibitor (IC50: 0.15 μM) that binds Keap1 strongly, useful for oxidative stress and inflammation research.</p>Formula:C28H32N2O10S2Colore e forma:SolidPeso molecolare:620.69Nrf2 activator-5
CAS:<p>Nrf2 activator-5 combats oxidative stress and inflammation in microglia, with potent antioxidant effects.</p>Formula:C25H30Cl2O6Colore e forma:SolidPeso molecolare:497.41Keap1-Nrf2-IN-14
CAS:<p>Keap1-Nrf2-IN-14, a KEAP1-NRF2 inhibitor (IC50: 75 nM, Kd: 24 nM), boosts NRF2 gene expression, antioxidative and anti-inflammatory response.</p>Formula:C30H29NO8SColore e forma:SolidPeso molecolare:563.62NXPZ-2
CAS:<p>NXPZ-2, an oral Keap1-Nrf2 PPI inhibitor (Ki: 95 nM, EC50: 120-170 nM), may improve cognition and neuron health in AD.</p>Formula:C27H27N5O7S2Colore e forma:SolidPeso molecolare:597.66SPC-180002
CAS:<p>SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.</p>Formula:C18H23NO4Purezza:98%Colore e forma:SolidPeso molecolare:317.38Stigmane B
<p>Stigmane B activates Nrf2, decreases apoptosis and ROS, boosts antioxidants, and is neuroprotective.</p>Formula:C21H30O4Colore e forma:SolidPeso molecolare:346.46BPK-29
CAS:<p>BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.</p>Formula:C26H32ClN3O3Purezza:98%Colore e forma:SolidPeso molecolare:470AI-3
CAS:<p>Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor</p>Formula:C11H13ClO3S2Purezza:98%Colore e forma:SolidPeso molecolare:292.8Nrf2 activator-4
CAS:<p>Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.</p>Formula:C23H24ClF3N2O3Purezza:98.53%Colore e forma:SolidPeso molecolare:468.9K67
CAS:<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Formula:C29H30N2O7S2Purezza:98.43%Colore e forma:SolidPeso molecolare:582.69DDO-7263
CAS:<p>DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.</p>Formula:C14H9F2N3OPurezza:99.85%Colore e forma:SolidPeso molecolare:273.24CDDO-EA
CAS:<p>CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.</p>Formula:C33H46N2O3Purezza:99.66%Colore e forma:SolidPeso molecolare:518.73Keap1-Nrf2-IN-15
CAS:<p>Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence</p>Formula:C39H35N3O12S2Colore e forma:SolidPeso molecolare:801.84Keap1-Nrf2-IN-16
CAS:<p>Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.</p>Formula:C73H114N16O26Colore e forma:SolidPeso molecolare:1631.78Keap1-Nrf2-IN-6
<p>Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM</p>Formula:C30H34N4O8SColore e forma:SolidPeso molecolare:610.68Nrf2-IN-1
CAS:<p>Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).</p>Formula:C21H22ClN3O2Purezza:95.00% - 99.68%Colore e forma:SolidPeso molecolare:383.87Nrf2 activator-7
CAS:<p>Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.</p>Formula:C35H32N2O11S2Colore e forma:SolidPeso molecolare:720.77Nrf2-IN-3
CAS:<p>Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.</p>Formula:C22H26N4O4SPurezza:98.07%Colore e forma:SolidPeso molecolare:442.53CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Formula:C6H6S3Colore e forma:SolidPeso molecolare:174.307Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Formula:C20H17BrO3Colore e forma:SolidPeso molecolare:385.25Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Formula:C31H37ClFN5O5Colore e forma:SolidPeso molecolare:614.11Keap1-Nrf2-IN-5
CAS:<p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>Formula:C23H30N4O6SColore e forma:SolidPeso molecolare:490.57VVD-130037
CAS:<p>VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.</p>Formula:C17H17ClN4O2Purezza:99.01% - 99.92%Colore e forma:SolidPeso molecolare:344.8KI696
CAS:<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Formula:C28H30N4O6SPurezza:99.74%Colore e forma:SolidPeso molecolare:550.63NSC23925
CAS:NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formula:C22H26Cl2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:421.36
