CXCR
I CXCR sono una sottoclasse di GPCR che si legano alle chemochine, piccole proteine segnale che guidano il movimento delle cellule immunitarie verso i siti di infiammazione, infezione o lesione. I CXCR svolgono ruoli cruciali nelle risposte immunitarie, nella metastasi del cancro e nelle malattie infiammatorie. I modulatori dei CXCR sono studiati per il loro potenziale nel trattamento delle malattie autoimmuni, del cancro e delle condizioni infiammatorie croniche. Presso CymitQuimica, offriamo una gamma di modulatori di CXCR di alta qualità per supportare la tua ricerca in immunologia, oncologia e infiammazione.
Trovati 159 prodotti di "CXCR"
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CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formula:C15H14F2N4O2SColore e forma:SolidPeso molecolare:352.36ACT-672125
CAS:ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formula:C25H25F3N10O2SColore e forma:SolidPeso molecolare:586.59Paeoniflorin-6′-O-benzene sulfonate
CAS:Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.Formula:C29H32O13SColore e forma:SolidPeso molecolare:620.622EMU-116
CAS:EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Formula:C25H35N5Colore e forma:SolidPeso molecolare:405.58CXCR4 modulator-1
CAS:CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formula:C23H27N5O2Colore e forma:SolidPeso molecolare:405.49CXCR4 antagonist 3
CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.Formula:C22H31N5Colore e forma:SolidPeso molecolare:365.52CCX662
CAS:CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formula:C28H37N5O4SColore e forma:SolidPeso molecolare:539.69SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formula:C23H27N3O5Purezza:98.03%Colore e forma:SolidPeso molecolare:425.48SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formula:C21H27N5O5SColore e forma:SolidPeso molecolare:461.535ACT-777991
CAS:ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formula:C20H20F6N8O2SColore e forma:SolidPeso molecolare:550.48CXCR2 antagonist 7
CXCR2 antagonist 7 is a powerful blocker with IC50s: 0.044 μM for binding, 0.66 μM for calcium mobilization.Formula:C14H14F2N6OSColore e forma:SolidPeso molecolare:352.36CXCR7 modulator 2
CAS:CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM.Formula:C29H42N6O3Colore e forma:SolidPeso molecolare:522.68CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formula:C18H18N4O4Colore e forma:SolidPeso molecolare:354.36CXCR7 antagonist-1 hydrochloride
CAS:CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.Formula:C21H20ClFN6OColore e forma:SolidPeso molecolare:426.87Ref: TM-T62325
1mgPrezzo su richiesta5mg455,00€10mg753,00€25mg1.491,00€50mg2.517,00€1mL*10mM (DMSO)Prezzo su richiestaCXCR2 antagonist 6
CXCR2 antagonist 6: strong CXCR2 affinity (IC50=0.044 μM), hinders calcium mobilization (IC50=0.66 μM).Formula:C17H16F2N4OSColore e forma:SolidPeso molecolare:362.4(R)-SCH 546738
CAS:(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formula:C23H31Cl2N7OColore e forma:SolidPeso molecolare:492.45CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formula:C15H14F2N4OS2Colore e forma:SolidPeso molecolare:368.42VUF11207 trifluoroacetate salt
CAS:VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.Formula:C29H36F4N2O6Colore e forma:SolidPeso molecolare:584.609CXCR4-IN-1
CAS:<p>CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic</p>Formula:C23H32N6Purezza:98%Colore e forma:SolidPeso molecolare:392.54Ref: TM-T79059
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