TLR
I recettori Toll-like (TLR) sono una classe di proteine che svolgono un ruolo fondamentale nel sistema immunitario innato riconoscendo i pattern molecolari associati ai patogeni (PAMP) e iniziando risposte immunitarie. I TLR sono coinvolti nel rilevamento di un'ampia gamma di patogeni, tra cui batteri, virus e funghi, e sono essenziali per l'attivazione delle vie di segnalazione infiammatorie. La disregolazione della segnalazione dei TLR è associata a malattie infiammatorie croniche, disturbi autoimmuni e cancro. Presso CymitQuimica, offriamo una varietà di modulatori TLR di alta qualità per supportare la tua ricerca sull'immunità innata, l'infiammazione e le malattie infettive.
Trovati 73 prodotti di "TLR"
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TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
Formula:C17H23N5OPurezza:99.84%Colore e forma:SolidPeso molecolare:313.4CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formula:C19H22O7Purezza:98.66% - 99.80%Colore e forma:SolidPeso molecolare:362.37Ref: TM-T15020
1mg52,00€2mg70,00€5mg99,00€10mg168,00€25mg313,00€50mg469,00€100mg682,00€200mg938,00€1mL*10mM (DMSO)114,00€IAXO-102
CAS:IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Formula:C35H71NO5Purezza:98.17%Colore e forma:SolidPeso molecolare:585.94CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formula:C17H13F3N4O2Purezza:99.84%Colore e forma:SolidPeso molecolare:362.31Ref: TM-T15017
1mg50,00€5mg105,00€10mg160,00€25mg268,00€50mg409,00€100mg583,00€1mL*10mM (DMSO)117,00€BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formula:C23H29N3Purezza:99.94%Colore e forma:SoildPeso molecolare:347.5Ref: TM-T60052
1mg71,00€5mg161,00€10mg245,00€25mg405,00€50mg572,00€100mg772,00€500mgPrezzo su richiestaCU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formula:C27H24N2O8Purezza:98.49%Colore e forma:SolidPeso molecolare:504.49(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.Formula:C29H33N5O4Colore e forma:SolidPeso molecolare:515.6PVP-037.2
CAS:PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Formula:C23H20F3N5OColore e forma:SoildPeso molecolare:439.43RKH
PKH is a TLR4 antagonist, and it is a new tripeptide derived from Akkermansia muciniphila. PKH reduces inflammation-related cell activation and the overproduction of pro-inflammatory factors induced by sepsis.Formula:C18H33N9O4Peso molecolare:439.26555L07-2
CAS:L07-2 (Compound 6) is an active scaffold that includes a TLR7/8 agonist. It is suitable for the synthesis of immune-stimulating antibody conjugates (ISACs) used in cancer research.Formula:C56H83N15O14Colore e forma:SolidPeso molecolare:1190.35TLR7/8 agonist 12
TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.
Formula:C29H38N6O3Colore e forma:SolidPeso molecolare:518.65Pam3CSK4-Biotin
CAS:Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Formula:C103H192N14O17S2Purezza:98%Colore e forma:SolidPeso molecolare:1962.85Tilsotolimod sodium
CAS:Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Formula:C223H262N74Na22O115P22S22Colore e forma:SolidPeso molecolare:7711.51Pam2CSK4
CAS:TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Formula:C65H126N10O12SPurezza:98%Colore e forma:SolidPeso molecolare:1271.83MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Colore e forma:Odour SolidTLR8 agonist 7
CAS:TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Formula:C54H63N9O16Colore e forma:SolidPeso molecolare:1094.13CRX 527
CAS:CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Formula:C81H151N2O19PColore e forma:SolidPeso molecolare:1488.04Ezeprogind
CAS:Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFormula:C25H44N6Purezza:99.28%Colore e forma:SolidPeso molecolare:428.66TLR8 agonist 8
CAS:TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formula:C53H63N11O10Colore e forma:SolidPeso molecolare:1014.14TLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formula:C25H37N7O3Colore e forma:SolidPeso molecolare:483.61
