TLR
I recettori Toll-like (TLR) sono una classe di proteine che svolgono un ruolo fondamentale nel sistema immunitario innato riconoscendo i pattern molecolari associati ai patogeni (PAMP) e iniziando risposte immunitarie. I TLR sono coinvolti nel rilevamento di un'ampia gamma di patogeni, tra cui batteri, virus e funghi, e sono essenziali per l'attivazione delle vie di segnalazione infiammatorie. La disregolazione della segnalazione dei TLR è associata a malattie infiammatorie croniche, disturbi autoimmuni e cancro. Presso CymitQuimica, offriamo una varietà di modulatori TLR di alta qualità per supportare la tua ricerca sull'immunità innata, l'infiammazione e le malattie infettive.
Trovati 76 prodotti di "TLR"
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Motolimod
CAS:Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.Formula:C28H34N4O2Purezza:97.43% - 99.66%Colore e forma:SolidPeso molecolare:458.6TLR7/8 agonist 1 dihydrochloride
CAS:TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.Formula:C22H27Cl2N5Purezza:98.33%Colore e forma:SolidPeso molecolare:432.39Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formula:C33H40O19Purezza:98.78% - 99.13%Colore e forma:SolidPeso molecolare:740.66Paridiprubart
CAS:Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.Purezza:95% - 96.9% (SDS-PAGE); 98.5% (SEC-HPLC)Colore e forma:LiquidAZD8848
CAS:AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Formula:C29H43N7O5Colore e forma:SolidPeso molecolare:569.7TLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Formula:C21H25N5OPurezza:98%Colore e forma:SolidPeso molecolare:363.46CL264
CAS:CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.Formula:C19H23N7O4Purezza:98.01%Colore e forma:SolidPeso molecolare:413.43DSR-6434
CAS:<p>DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.</p>Formula:C19H28N8O2Purezza:99.78%Colore e forma:SolidPeso molecolare:400.48AXC-715 trihydrochloride
CAS:AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.Formula:C18H28Cl3N5Purezza:99.87%Colore e forma:SolidPeso molecolare:420.81AT791
CAS:AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Formula:C23H31N3O3Purezza:99.88%Colore e forma:SolidPeso molecolare:397.51TLR7/8-IN-1
CAS:<p>TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.</p>Formula:C29H40N8O2Purezza:99.83%Colore e forma:SolidPeso molecolare:532.68Rabeximod
CAS:<p>Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.</p>Formula:C22H24ClN5OPurezza:99.99%Colore e forma:SolidPeso molecolare:409.91BBIQ
CAS:BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1Formula:C21H22N4Purezza:99.71%Colore e forma:SolidPeso molecolare:330.43M62812
CAS:TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Formula:C13H13Cl2N3OSPurezza:99.07%Colore e forma:SolidPeso molecolare:330.23SM360320
CAS:<p>SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.</p>Formula:C15H17N5O3Purezza:99.13%Colore e forma:SolidPeso molecolare:315.331Z105
CAS:1Z105, an orally active TLR4/MD2 ligand, facilitates dendritic cell maturation and antigen presentation, thereby preventing arthritis.Formula:C25H26N4O2SPeso molecolare:446.57TLR7 agonist 23
CAS:TLR7 agonist23 (compound 12b) is a potent agonist of Toll-like receptor-7 (TLR7), with an EC50 value of 0.15 uM. It is suitable for research in immune diseases.Formula:C21H22N4O2Colore e forma:SolidPeso molecolare:362.42TLR9-IN-1
CAS:<p>TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.</p>Formula:C23H31N7OColore e forma:SolidPeso molecolare:421.54CU-CPD107
CAS:CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.Formula:C16H21IN2O2Purezza:98%Colore e forma:SolidPeso molecolare:400.25ABR-238901
CAS:ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end productsFormula:C11H9BrClN3O4SPurezza:98.63% - 98.71%Colore e forma:SolidPeso molecolare:394.63SARM1-IN-4
CAS:SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.Formula:C13H17F2N3O2Colore e forma:SolidPeso molecolare:285.29SARM1-IN-5
CAS:SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).Formula:C18H17FN6OColore e forma:SolidPeso molecolare:352.37TLR7 agonist 28
CAS:TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.Formula:C26H25N9O7Colore e forma:SolidPeso molecolare:575.533Creatine ethyl ester
CAS:Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.Formula:C6H13N3O2Colore e forma:SolidPeso molecolare:159.186LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formula:C29H32F2N3O7PPurezza:98%Colore e forma:SolidPeso molecolare:603.55TLR7/8/9 antagonist 2
CAS:<p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>Formula:C23H31N7Purezza:98%Colore e forma:SoildPeso molecolare:405.54
