TGF-beta/Smad
Gli inibitori del percorso TGF-beta/Smad sono composti che interferiscono con la via di segnalazione TGF-beta (Transforming Growth Factor-beta), mediata dalle proteine Smad. Questa via è coinvolta nella regolazione della crescita cellulare, della differenziazione, dell'apoptosi e della funzione delle cellule staminali. La disfunzione della segnalazione TGF-beta/Smad è associata al cancro, alla fibrosi e ad altre malattie. Gli inibitori di questa via sono strumenti importanti per studiare queste condizioni e sviluppare potenziali terapie. Presso CymitQuimica, forniamo inibitori di TGF-beta/Smad per supportare la tua ricerca nella segnalazione cellulare, in oncologia e nella riparazione dei tessuti.
Trovati 61 prodotti di "TGF-beta/Smad"
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SRI-011381 hydrochloride
CAS:SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formula:C20H32ClN3OPurezza:99.32% - 99.41%Colore e forma:SolidPeso molecolare:365.94Ref: TM-T5129
1mg35,00€2mg47,00€5mg70,00€10mg111,00€25mg227,00€50mg354,00€100mg525,00€200mg797,00€1mL*10mM (DMSO)77,00€Asiaticoside
CAS:Asiaticoside, in Centella asiatica, may treat wounds/burns.Formula:C48H78O19Purezza:98% - 99.96%Colore e forma:PowderPeso molecolare:959.12Chebulinic acid
CAS:Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Formula:C41H32O27Purezza:98.91% - 99.71%Colore e forma:SolidPeso molecolare:956.68Ref: TM-TQ0184
1mg70,00€5mg154,00€10mg215,00€25mg432,00€50mg628,00€100mg879,00€1mL*10mM (DMSO)226,00€(E)-SIS3
CAS:(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!Formula:C28H27N3O3·HClPurezza:95.64% - 98%Colore e forma:SolidPeso molecolare:489.99Ref: TM-T3636
1mg43,00€2mg57,00€5mg111,00€10mg167,00€25mg344,00€50mg512,00€100mg730,00€500mg1.473,00€1mL*10mM (DMSO)120,00€R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formula:C20H18FN5OPurezza:99.61%Colore e forma:SolidPeso molecolare:363.39Ref: TM-T16708
1mg44,00€5mg93,00€10mg130,00€25mg250,00€50mg378,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)92,00€SJ000291942
CAS:SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Formula:C16H15FN2O4Purezza:99.66%Colore e forma:SolidPeso molecolare:318.3Ref: TM-T4662
1mg35,00€2mg47,00€5mg66,00€10mg105,00€25mg216,00€50mg369,00€100mg588,00€200mg833,00€1mL*10mM (DMSO)74,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Formula:C25H44F6N6O9Purezza:99.75%Colore e forma:SolidPeso molecolare:686.64Ref: TM-T7676
2mg44,00€5mg57,00€10mg88,00€25mg145,00€50mg217,00€100mg334,00€200mg467,00€1mL*10mM (DMSO)87,00€Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formula:C20H15NO3Purezza:96.25% - 97.79%Colore e forma:SolidPeso molecolare:317.34ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Formula:C27H29NO3Purezza:99.89% - >99.99%Colore e forma:SolidPeso molecolare:415.52Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Formula:C22H19N5OPurezza:97.09% - 99.98%Colore e forma:SolidPeso molecolare:369.42Ref: TM-T2510
1g692,00€5mg48,00€10mg55,00€25mg88,00€50mg120,00€100mg188,00€200mg284,00€500mg467,00€1mL*10mM (DMSO)50,00€Alantolactone
CAS:Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.Formula:C15H20O2Purezza:99.02% - 99.66%Colore e forma:Crystalline PowderPeso molecolare:232.32BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Formula:C14H10BrNOSPurezza:99.48% - 99.805%Colore e forma:SolidPeso molecolare:320.2Ref: TM-T7799
5mg47,00€10mg60,00€25mg88,00€50mg126,00€100mg187,00€200mg283,00€500mg490,00€1mL*10mM (DMSO)50,00€BMS986260
CAS:BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Formula:C18H12ClFN6OPurezza:97.67%Colore e forma:SolidPeso molecolare:382.78BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formula:C17H13N5Purezza:99.87%Colore e forma:SolidPeso molecolare:287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€Trimethylamine N-oxide dihydrate
CAS:TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.Formula:C3H13NO3Purezza:98.75%Colore e forma:White CrystalPeso molecolare:111.14LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Formula:C24H29N5O3Purezza:99.46% - 99.63%Colore e forma:SolidPeso molecolare:435.52SRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Formula:C20H31N3OPurezza:98.64%Colore e forma:SolidPeso molecolare:329.48Nisevokitug
CAS:Nisevokitug (anti-TGF-β mAb) neutralizes TGF-β and is being studied for its ability to modulate the immunosuppressive tumor microenvironment.Purezza:95%Colore e forma:LiquidPeso molecolare:143.51 kDaGinisortamab
CAS:Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.Purezza:95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)Colore e forma:LiquidMetelimumab
CAS:Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).Purezza:95%Colore e forma:Liquid
