MALT
Il tessuto linfoide associato alla mucosa (MALT) è un componente essenziale del sistema immunitario che protegge le superfici mucose dai patogeni. Il MALT comprende strutture come le tonsille, le placche di Peyer e l'appendice, che sono coinvolte nell'inizio delle risposte immunitarie agli antigeni incontrati sulle superfici mucose. La ricerca sul MALT è fondamentale per comprendere i meccanismi dell'immunità mucosale e per lo sviluppo di vaccini e trattamenti per le infezioni mucosali. Presso CymitQuimica, offriamo una gamma di reagenti e strumenti per supportare la tua ricerca in immunologia mucosale, infiammazione e malattie infettive.
Trovati 25 prodotti di "MALT"
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MLT-231
MLT-231: potent MALT1 Inhibitor, IC50=9 nM; blocks BCL10 cleavage, IC50=160 nM; exhibits antitumor efficacy in mouse ABC-DLBCL model.Colore e forma:SolidMALT1-IN-14
CAS:MALT1-IN-14 (comp 2) acts as an inhibitor of MALT1, boasting an IC50 value of 0.081 μM.Formula:C26H25ClF5N5O3SPeso molecolare:618.02MLT-985
CAS:MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC 50 value of 3 nM.Formula:C17H15Cl2N9O2Colore e forma:SolidPeso molecolare:448.27Cladribine
CAS:Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.Formula:C10H12ClN5O3Purezza:99.58% - >99.99%Colore e forma:White Crystalline SolidPeso molecolare:285.69MLT-943
CAS:MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].Formula:C16H14ClF3N6O2Purezza:99.72% - 99.82%Colore e forma:SolidPeso molecolare:414.77Ref: TM-T9216
1mg81,00€5mg156,00€10mg226,00€25mg379,00€50mg538,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)170,00€MALT1 inhibitor MI-2
CAS:<p>MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.</p>Formula:C19H17Cl3N4O3Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:455.72MLT-748
CAS:MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).Formula:C19H19Cl2N9O3Purezza:99.62%Colore e forma:SolidPeso molecolare:492.32Ref: TM-T16120
1mg99,00€5mg235,00€10mg374,00€25mg558,00€50mg747,00€100mg1.159,00€1mL*10mM (DMSO)255,00€(R)-MALT1-IN-3
CAS:(R)-MALT1-IN-3 (121) inhibits MALT1 protease (IC50: 20 nM) and IL6/IL10 in OCI-LY3 (IC50: 60/40 nM).Formula:C21H19F3N8O2Colore e forma:SolidPeso molecolare:472.42MALT1-IN-8
CAS:MALT1-IN-8: potent MALT1 inhibitor, IC50=2 nM; hinders OCI-LY3 cells, IC50=1.16 μM; anticancer, from patent WO2018165385A1.Formula:C20H15Cl2N7OColore e forma:SolidPeso molecolare:440.29MALT1-IN-3
CAS:MALT1-IN-3 is a potent inhibitor of MALT1 protease (IC50: 0.06 μM) with IC50 values of 0.14 and 0.13 μM for human IL6 and IL10, respectively, in OCI-LY3 cells.Formula:C21H19F3N8O2Colore e forma:SolidPeso molecolare:472.42Z-VRPR-FMK
CAS:Z-VRPR-FMK: irreversible MALT1 inhibitor, halts growth/invasion of diffused B-cell lymphoma by blocking NF-κB activation and MMP expression.Formula:C31H49FN10O6Colore e forma:SolidPeso molecolare:676.78MLT-747
CAS:MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).Formula:C20H21Cl2N7O3Colore e forma:SolidPeso molecolare:478.33(R)-MLT-985
CAS:(R)-MLT-985 (compound 11) is a MALT1 protease inhibitor with IC50 of 3 nM, also blocking IL-2 in Jurkat cells and ABC-DLBCL cell growth.Formula:C17H15Cl2N9O2Colore e forma:SolidPeso molecolare:448.27(R)-MALT1-IN-7
CAS:(R)-MALT1-IN-7 (compound 142a) is a potent inhibitor of MALT1 protease and has potential for cancer research.Formula:C19H17F3N8O2SColore e forma:SolidPeso molecolare:478.45MALT1-IN-7
CAS:MALT1-IN-7 (compound 142b) is a potent inhibitor of MALT1 protease with potential for cancer research.Formula:C19H17F3N8O2SColore e forma:SolidPeso molecolare:478.45MALT1-IN-9
CAS:MALT1-IN-9: potent MALT1 protease inhibitor, IC50 <500 nM in Raji cells, significant anticancer effects.Formula:C16H12ClF3N6OColore e forma:SolidPeso molecolare:396.75MALT1-IN-6
CAS:MALT1-IN-6 is a MALT1 protease inhibitor (Ki: 9 nM) that exhibits anticancer activity.Formula:C18H12Cl2F3N9OColore e forma:SolidPeso molecolare:498.25NVS-MALT1
CAS:NVS-MALT1 is an allosteric inhibitor of MALT1 [1].Formula:C24H27ClF3N5O4SColore e forma:SolidPeso molecolare:574.02JNJ-67856633
CAS:JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease .Formula:C20H11F6N5O2Purezza:99.87%Colore e forma:SolidPeso molecolare:467.32Ref: TM-T36670
1mg52,00€5mg111,00€10mg180,00€25mg309,00€50mg460,00€100mg692,00€200mg933,00€1mL*10mM (DMSO)115,00€MALT1-IN-5
CAS:MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.Formula:C17H17ClF2N6O3Colore e forma:SolidPeso molecolare:426.80(S)-MALT1-IN-5
CAS:(S)-MALT1-IN-5: Potent MALT1 protease inhibitor, may help in abnormal T/B-cell signalling and MALT1-linked diseases.Formula:C17H17ClF2N6O3Colore e forma:SolidPeso molecolare:426.80(S,R,S)-AHPC-Boc derivative 1
CAS:(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).Formula:C28H40N4O6SColore e forma:SolidPeso molecolare:560.705MALT1-IN-11
CAS:MALT1-IN-11: MALT1 inhibitor, IC50 <10-100 nM, reduces IL10, for cancer/autoimmune research.Formula:C20H16F4N8OColore e forma:SolidPeso molecolare:460.39RGT-068A
CAS:RGT-068A is a potent, selective and oral bioavailable MALT1 inhibitor .Formula:C17H16ClN9O2Colore e forma:SolidPeso molecolare:413.82Ocipumaltib
CAS:Ocipumaltib (Example 2) is an inhibitor of mucosa-associated lymphoid tissue protein 1 (MALT1). It functions as an antineoplastic agent and is utilized in the study of cancer, infections, neurological disorders, and hematological diseases.Formula:C20H16ClF3N8O2Colore e forma:SolidPeso molecolare:492.84
