STAT
Le proteine STAT sono componenti critici della via di segnalazione JAK/STAT, che trasmette segnali extracellulari da citochine e fattori di crescita al nucleo cellulare, influenzando l'espressione genica. Le proteine STAT sono coinvolte nella regolazione delle risposte immunitarie, della crescita cellulare, della differenziazione e della sopravvivenza. La disregolazione della segnalazione STAT è implicata in varie malattie, tra cui cancro, disturbi autoimmuni e infiammazione cronica. Presso CymitQuimica, offriamo una gamma completa di modulatori della via STAT per supportare la tua ricerca sulla trasduzione del segnale, immunologia e sviluppo terapeutico.
Trovati 98 prodotti di "STAT"
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Balsalazide disodium dihydrate
CAS:<p>Balsalazide sodium hydrate treats mild-to-moderate ulcerative colitis; higher doses enhance remission maintenance; it's safe and effective.</p>Formula:C17H17N3Na2O8Purezza:98.95% - 99.49%Colore e forma:Yellow To Orange Crystalline PowderPeso molecolare:437.31BP-1-102
CAS:<p>BP-1-102 is an orally active, effective and specific STAT3 inhibitor.</p>Formula:C29H27F5N2O6SPurezza:99.25% - 99.44%Colore e forma:SolidPeso molecolare:626.59ML116
CAS:ML116 is a potent and selective STAT3 inhibitor.Formula:C18H19N3SPurezza:99.49%Colore e forma:SolidPeso molecolare:309.43Picroside I
CAS:Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.Formula:C24H28O11Purezza:99.70%Colore e forma:SolidPeso molecolare:492.47SH5-07
CAS:<p>SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).</p>Formula:C29H28F5N3O5SPurezza:95.54%Colore e forma:SolidPeso molecolare:625.61FLLL32
CAS:<p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).</p>Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.552-(1,8-naphthyridin-2-yl)phenol
CAS:2-NP is a STAT1 enhancer.Formula:C14H10N2OPurezza:99.33% - 99.82%Colore e forma:SolidPeso molecolare:222.24TPCA-1
CAS:TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFormula:C12H10FN3O2SPurezza:95.03% - 97.86%Colore e forma:SolidPeso molecolare:279.29Saikosaponin D
CAS:Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.Formula:C42H68O13Purezza:98.34% - 99.73%Colore e forma:White PowderPeso molecolare:780.98Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formula:C15H12O5Purezza:99.42% - 99.82%Colore e forma:SolidPeso molecolare:272.25AS1517499
CAS:AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!Formula:C20H20ClN5O2Purezza:98.27% - 99.3%Colore e forma:SolidPeso molecolare:397.86BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormula:C14H13N3OSPurezza:99.02%Colore e forma:SolidPeso molecolare:271.34Astaxanthin
CAS:<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>Formula:C40H52O4Purezza:95.1% - 99.79%Colore e forma:Needles From Acetone/Light Petroleum SolidPeso molecolare:596.84AS1810722
CAS:AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.Formula:C25H25F2N7OPurezza:99.13%Colore e forma:SolidPeso molecolare:477.511-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS:<p>SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.</p>Formula:C21H13ClF3N3O2Purezza:99.41%Colore e forma:SolidPeso molecolare:431.8Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formula:C15H18O2Purezza:97.55% - 99.92%Colore e forma:SolidPeso molecolare:230.3C188-9
CAS:C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.Formula:C27H21NO5SPurezza:98.07% - >99.99%Colore e forma:SolidPeso molecolare:471.52Casticin
CAS:Casticin combats vascular inflammation by blocking ROS-NF-κB and could lead in prostate cancer treatment.Formula:C19H18O8Purezza:99.37% - ≥95%Colore e forma:SolidPeso molecolare:374.34Fraxinellone
CAS:<p>1.</p>Formula:C14H16O3Purezza:99.35% - 99.92%Colore e forma:SolidPeso molecolare:232.27AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purezza:98.6% - 99.85%Colore e forma:Yellow SolidPeso molecolare:294.3Alantolactone
CAS:Alantolactone is a selective inhibitor of STAT3 that induces cancer-associated apoptosis and has antitumor activity.Cost-effective and quality-assured.Formula:C15H20O2Purezza:99.02% - 99.66%Colore e forma:Crystalline PowderPeso molecolare:232.32Angoline
CAS:<p>Angoline hydrochloride: IL6/STAT3 inhibitor, IC50: 11.56 μM, blocks STAT3 phosphorylation and cancer cell growth.</p>Formula:C22H21NO5Purezza:99.43% - 99.96%Colore e forma:SolidPeso molecolare:379.41Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purezza:99.85% - 99.90%Colore e forma:SolidPeso molecolare:476.73Colivelin
CAS:Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).Formula:C119H206N32O35Purezza:96.56%Colore e forma:SolidPeso molecolare:2645.1Garcinone D
CAS:<p>Garcinone D is cytotoxic to CEM-SS cells (IC50=3.2 µg/ml), inhibits aromatase and p65 activation (IC50=3.2 µM).</p>Formula:C24H28O7Purezza:99.94%Colore e forma:SolidPeso molecolare:428.47Triacetylresveratrol
CAS:<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Formula:C20H18O6Purezza:99.81%Colore e forma:Off White PowderPeso molecolare:354.35Stafia-1
CAS:Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.Formula:C24H27O10PPurezza:98.08%Colore e forma:SolidPeso molecolare:506.44Ochromycinone
CAS:Ochromycinone (STA 21) is a selective STAT3 inhibitor.Formula:C19H14O4Purezza:99.21%Colore e forma:SolidPeso molecolare:306.31Panaxadiol
CAS:<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Formula:C30H52O3Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:460.73Tetramethylcurcumin
CAS:Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it alsoFormula:C25H28O6Purezza:97.69% - 99.94%Colore e forma:SolidPeso molecolare:424.49Stattic
CAS:<p>Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.</p>Formula:C8H5NO4SPurezza:98.32% - 99.76%Colore e forma:SolidPeso molecolare:211.19Homoharringtonine
CAS:Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.Formula:C29H39NO9Purezza:98.21% - 99.91%Colore e forma:Off-White CrystPeso molecolare:545.62MMPP
CAS:MMPP is a VEGFR2 inhibitor with anti-inflammatory activity, inhibits STAT3 , inhibits angiogenesis, and can be used to alleviate myocardial injury.Formula:C17H18O3Purezza:99.31% - 99.83%Colore e forma:SolidPeso molecolare:270.32inS3-54-A26
CAS:<p>inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.</p>Formula:C25H19ClN2O2Purezza:99.57%Colore e forma:SolidPeso molecolare:414.88Stafib-2
CAS:<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Formula:C28H26N2O12P2Purezza:98.48%Colore e forma:SolidPeso molecolare:644.46STAT3-IN-B9
CAS:STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.Formula:C20H13NO5SPurezza:98.19%Colore e forma:SolidPeso molecolare:379.39ML115
CAS:ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formula:C15H15ClN2O4Purezza:99.97%Colore e forma:SolidPeso molecolare:322.74STAT3-IN-20
CAS:STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFormula:C30H27F4N7SPurezza:98%Colore e forma:SolidPeso molecolare:593.64Antitumor agent-73
CAS:Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.Formula:C50H82BrO4PPurezza:98%Colore e forma:SolidPeso molecolare:858.06STAT6-IN-3
CAS:STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.Formula:C32H35IN3O7PPurezza:98%Colore e forma:SolidPeso molecolare:731.51inS3-54A18
CAS:<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Formula:C23H16ClNO2Purezza:99.68%Colore e forma:SolidPeso molecolare:373.83STAT6-IN-2
CAS:STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.Formula:C28H31N5O2Purezza:99.67%Colore e forma:SolidPeso molecolare:469.58PMMB-187
CAS:<p>PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.</p>Formula:C27H23BrN2O6S2Colore e forma:SolidPeso molecolare:615.52WZ-2-033
CAS:<p>WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.</p>Formula:C25H18F3N3O4SColore e forma:SolidPeso molecolare:513.49STAT3-IN-36
CAS:<p>STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.</p>Formula:C30H24F2N2O9S2Colore e forma:SolidPeso molecolare:658.65STAT3-IN-35
CAS:<p>STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.</p>Formula:C21H23NO4Colore e forma:SolidPeso molecolare:353.41STAT3-IN-8
CAS:<p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>Formula:C19H7F7N2O3Purezza:98%Colore e forma:SolidPeso molecolare:444.26
