Pim
Le chinasi Pim sono una famiglia di chinasi serina/treonina che svolgono un ruolo chiave nella sopravvivenza cellulare, nella proliferazione e nell'apoptosi. Queste chinasi sono effettori a valle nella via di segnalazione JAK/STAT e sono coinvolte in vari processi fisiologici, comprese le risposte immunitarie e l'ematopoiesi. La sovraespressione delle chinasi Pim è stata associata allo sviluppo del cancro, rendendole importanti bersagli per l'intervento terapeutico. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori delle chinasi Pim di alta qualità per supportare la tua ricerca in oncologia, biologia cellulare e trasduzione del segnale.
Trovati 32 prodotti di "Pim"
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Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Formula:C26H29F3N5O7PPurezza:99.75% - 99.79%Colore e forma:SolidPeso molecolare:611.51Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Formula:C14H17N3O3Purezza:99.81%Colore e forma:SoildPeso molecolare:275.3R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formula:C111H211N59O26SPurezza:98%Colore e forma:SolidPeso molecolare:2820.33Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.
Colore e forma:Odour SolidVB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Formula:C27H27N3O3Colore e forma:SolidPeso molecolare:441.522Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formula:C11H9NO3SPurezza:99.78%Colore e forma:SolidPeso molecolare:235.26HJ-PI01
CAS:HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.
Formula:C14H11NO2Purezza:98.92%Colore e forma:SolidPeso molecolare:225.24AZD1208
CAS:AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
Formula:C21H21N3O2SPurezza:97.24% - 99.83%Colore e forma:SolidPeso molecolare:379.48(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Formula:C11H6F3NO2SPurezza:97.66% - 99.93%Colore e forma:SolidPeso molecolare:273.23TCS-PIM-1-4a
CAS:SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).Formula:C11H6F3NO2SPurezza:99.89%Colore e forma:SolidPeso molecolare:273.23SMI-16a
CAS:SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (Formula:C13H13NO3SPurezza:99.99%Colore e forma:SolidPeso molecolare:263.31Ref: TM-T3989
1mg34,00€2mg46,00€5mg66,00€10mg93,00€25mg152,00€50mg222,00€100mg334,00€1mL*10mM (DMSO)87,00€Quercetagetin
CAS:Quercetagetin, a flavonoid from Citrus unshiu, inhibits pim-1 kinase (IC50: 0.34 μM), cell-permeable.Formula:C15H10O8Purezza:99.65% - 99.91%Colore e forma:SolidPeso molecolare:318.24Ref: TM-T8114
1mg94,00€5mg192,00€10mg286,00€25mg482,00€50mg695,00€100mg945,00€500mg1.882,00€1mL*10mM (DMSO)202,00€Hispidulin
CAS:Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).Formula:C16H12O6Purezza:98.53% - 99.87%Colore e forma:SolidPeso molecolare:300.26SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurezza:99.3% - >99.99%Colore e forma:SolidPeso molecolare:405.42Pim1/AKK1-IN-1
CAS:Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.Formula:C20H13N5OPurezza:97.03% - 98.69%Colore e forma:SolidPeso molecolare:339.35Ref: TM-T5093
1mg85,00€2mg124,00€5mg173,00€10mg263,00€25mg464,00€50mg672,00€100mg945,00€1mL*10mM (DMSO)192,00€TCS PIM-1 1
CAS:TCS PIM-1 1 (SC 204330) is a potent ATP-competitive inhibitor of Pim-1 kinase with an IC50 of 50 nM, selective over MEK1/2 and Pim-2.Formula:C18H11BrN2O2Purezza:97% - 97.98%Colore e forma:SolidPeso molecolare:367.2Ref: TM-T2253
1mg35,00€5mg64,00€10mg88,00€25mg187,00€50mg284,00€100mg424,00€200mg612,00€1mL*10mM (DMSO)97,00€TP-3654
CAS:TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).Formula:C22H25F3N4OPurezza:99.8% - 99.95%Colore e forma:SolidPeso molecolare:418.46CX-6258 hydrochloride
CAS:CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).Formula:C26H24ClN3O3·HClPurezza:96.03% - 98.60%Colore e forma:SolidPeso molecolare:498.4Ref: TM-T6148
1mg40,00€5mg84,00€10mg120,00€25mg222,00€50mg356,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)93,00€K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Formula:C18H18N4OPurezza:98.16%Colore e forma:SolidPeso molecolare:306.36CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Formula:C26H24ClN3O3Purezza:97.46%Colore e forma:SolidPeso molecolare:461.94Ref: TM-T1834
1mg34,00€5mg75,00€10mg101,00€25mg197,00€50mg295,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)77,00€AZD-1897
CAS:AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.Formula:C18H23N3O3SPurezza:99.49%Colore e forma:SolidPeso molecolare:361.46M-110
CAS:M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).Formula:C22H28ClN5O3Purezza:99.55%Colore e forma:SolidPeso molecolare:445.94Ref: TM-T15830
5mg60,00€10mg96,00€25mgPrezzo su richiesta50mgPrezzo su richiesta1mL*10mM (DMSO)60,00€PIM-1 Inhibitor 2
CAS:PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.Formula:C17H11ClN4OPurezza:98.81%Colore e forma:SolidPeso molecolare:322.75FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Formula:C21H20F2N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:430.47GNE-955
CAS:GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).Formula:C22H24N8OPurezza:98%Colore e forma:SolidPeso molecolare:416.48PIM1-IN-4
CAS:PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.Formula:C27H25BrCl2CuN6OPurezza:98%Colore e forma:SolidPeso molecolare:663.88Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Formula:C22H13Cl2N3OPurezza:98%Colore e forma:SolidPeso molecolare:406.26PIM1-IN-1
CAS:PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.Formula:C25H30N8O2Purezza:98%Colore e forma:SolidPeso molecolare:474.56PIM-IN-2
CAS:PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .Formula:C19H22N4O2Purezza:98%Colore e forma:SolidPeso molecolare:338.4HS94
CAS:HS94 (DAPK3 inhibitor HS94) is a selective and potent DAPK3 inhibitor with a Ki value of 126 nM for Pim kinase inhibition and can be used to study hypertension.
Formula:C15H15N5O2SPurezza:95.04%Colore e forma:SolidPeso molecolare:329.38GDC-0339
CAS:GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.Formula:C20H22F3N7OSColore e forma:SolidPeso molecolare:465.5Pim-1 kinase inhibitor 6
CAS:Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].Formula:C21H10BrCl2N3Colore e forma:SolidPeso molecolare:455.13
