CymitQuimica logo
Pim

Pim

Le chinasi Pim sono una famiglia di chinasi serina/treonina che svolgono un ruolo chiave nella sopravvivenza cellulare, nella proliferazione e nell'apoptosi. Queste chinasi sono effettori a valle nella via di segnalazione JAK/STAT e sono coinvolte in vari processi fisiologici, comprese le risposte immunitarie e l'ematopoiesi. La sovraespressione delle chinasi Pim è stata associata allo sviluppo del cancro, rendendole importanti bersagli per l'intervento terapeutico. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori delle chinasi Pim di alta qualità per supportare la tua ricerca in oncologia, biologia cellulare e trasduzione del segnale.

Trovati 35 prodotti per "Pim".

prodotti per pagina.
  • VB1080
    Targetmol
    + Info

    VB1080

    VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.
    Formula:C27H27N3O3
    Colore e forma:Solid
    Peso molecolare:441.522

    Ref: TM-T204937

  • PIM-1 Inhibitor 2
    Targetmol
    + Info

    PIM-1 Inhibitor 2

    CAS:
    PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.
    Formula:C17H11ClN4O
    Purezza:98.81%
    Colore e forma:Solid
    Peso molecolare:322.75

    Ref: TM-T23158

  • K00135
    Targetmol
    + Info

    K00135

    CAS:
    K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.
    Formula:C18H18N4O
    Purezza:98.16%
    Colore e forma:Yellow Solid
    Peso molecolare:306.3617

    Ref: TM-T27704

  • AZD-1897
    Targetmol
    + Info

    AZD-1897

    CAS:
    AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.
    Formula:C18H23N3O3S
    Purezza:99.91%
    Colore e forma:Solid
    Peso molecolare:361.46

    Ref: TM-T71242

  • M-110
    Targetmol
    + Info

    M-110

    CAS:
    M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).
    Formula:C22H28ClN5O3
    Purezza:99.55%
    Colore e forma:Orange Solid
    Peso molecolare:445.942

    Ref: TM-T15830

  • CX-6258
    Targetmol
    + Info

    CX-6258

    CAS:
    CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.
    Formula:C26H24ClN3O3
    Purezza:97.46%
    Colore e forma:Solid
    Peso molecolare:461.94

    Ref: TM-T1834

  • PIM1-IN-1
    Targetmol
    + Info

    PIM1-IN-1

    CAS:
    PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.
    Formula:C25H30N8O2
    Purezza:98.59%
    Colore e forma:Yellow Solid
    Peso molecolare:474.5581

    Ref: TM-T12474

  • Pim-1 kinase inhibitor 5
    Targetmol
    + Info

    Pim-1 kinase inhibitor 5

    CAS:
    Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-
    Formula:C22H13Cl2N3O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:406.26

    Ref: TM-T78980

  • FD1024
    Targetmol
    + Info

    FD1024

    CAS:
    FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.
    Formula:C21H20F2N4O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:430.47

    Ref: TM-T79456

  • PIM-IN-2
    Targetmol
    + Info

    PIM-IN-2

    CAS:
    PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM .
    Formula:C19H22N4O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:338.4

    Ref: TM-T81460

  • PIM1-IN-4
    Targetmol
    + Info

    PIM1-IN-4

    CAS:
    PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.
    Formula:C27H25BrCl2CuN6O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:663.88

    Ref: TM-T73247

  • GNE-955
    Targetmol
    + Info

    GNE-955

    CAS:
    GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
    Formula:C22H24N8O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:416.48

    Ref: TM-T15406

  • GDC-0339
    Targetmol
    + Info

    GDC-0339

    CAS:
    GDC-0339: oral Pim kinase inhibitor for multiple myeloma (Kis: Pim1 - 0.03 nM, Pim2 - 0.1 nM, Pim3 - 0.02 nM), well-tolerated.
    Formula:C20H22F3N7OS
    Colore e forma:Solid
    Peso molecolare:465.495

    Ref: TM-T15376

  • CRT0066101
    Targetmol
    + Info

    CRT0066101

    CAS:
    CRT0066101 is a potent and orally active protein kinase D inhibitor with low-nanomolar activity against PKD1, PKD2, and PKD3, while also inhibiting PIM2, CRT0066101 demonstrates significant anti-inflammatory efficacy in lipopolysaccharide-induced lung injury models as well as anticancer activity, supporting its use in inflammation and oncology research.
    Formula:C18H22N6O
    Colore e forma:Solid
    Peso molecolare:338.41

    Ref: TM-T86093

  • Pim-1 kinase inhibitor 6
    Targetmol
    + Info

    Pim-1 kinase inhibitor 6

    CAS:
    Pim-1 kinase inhibitor 6 (Compound 4d) is a robust inhibitor of Pim-1 kinase, demonstrating an IC 50 of 0.46 μM. It significantly exhibits cytotoxic effects on cancer cells [1].
    Formula:C21H10BrCl2N3
    Colore e forma:Solid
    Peso molecolare:455.13

    Ref: TM-T87213