JAK
Gli inibitori della Janus chinasi (JAK) sono composti che prendono di mira la via di segnalazione JAK-STAT, coinvolta nella crescita cellulare, nella risposta immunitaria e nell'angiogenesi. Inibendo JAK, questi composti possono ridurre la segnalazione che porta alla formazione di nuovi vasi sanguigni nei tumori, inibendo così la crescita tumorale. Gli inibitori di JAK sono importanti nel trattamento del cancro e delle malattie infiammatorie. Presso CymitQuimica, offriamo una vasta gamma di inibitori di JAK di alta qualità per supportare la tua ricerca in oncologia, immunologia e angiogenesi.
Trovati 246 prodotti di "JAK"
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Pacritinib hydrochloride
CAS:Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.Formula:C28H32N4O3·xClHColore e forma:SolidNVP-BSK805 trihydrochloride
CAS:NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.Formula:C27H31Cl3F2N6OColore e forma:SolidPeso molecolare:599.93Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formula:C23H25ClFN7OPurezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:469.94Ref: TM-T2638
5mg51,00€10mg88,00€25mg160,00€50mg296,00€100mg469,00€500mg1.035,00€1mL*10mM (DMSO)57,00€Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Formula:C16H17N7O2SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:371.42Ref: TM-T2485
5mg50,00€10mg73,00€25mg90,00€50mg115,00€100mg144,00€200mg188,00€500mg311,00€1mL*10mM (DMSO)69,00€G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39Ref: TM-T8742
1mg38,00€5mg74,00€10mg101,00€25mg182,00€50mg261,00€100mg366,00€200mg497,00€1mL*10mM (DMSO)82,00€Momelotinib HCl
CAS:Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.Formula:C23H24Cl2N6O2Colore e forma:SolidPeso molecolare:487.38(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Formula:C23H24N4OPurezza:97.75% - 99.92%Colore e forma:SolidPeso molecolare:372.46Ref: TM-T21503
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg210,00€50mg349,00€100mg507,00€1mL*10mM (DMSO)96,00€AZ960
CAS:AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formula:C18H16F2N6Purezza:96.02% - 99.88%Colore e forma:SolidPeso molecolare:354.36FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63Ritlecitinib
CAS:Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formula:C15H19N5OPurezza:98.82% - 99.92%Colore e forma:SolidPeso molecolare:285.34Ref: TM-T5382
2mg39,00€5mg56,00€10mg96,00€25mg216,00€50mg306,00€100mg430,00€200mg628,00€1mL*10mM (DMSO)77,00€AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formula:C29H28F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:535.56Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Formula:C17H18N6Purezza:99.37% - 99.79%Colore e forma:SolidPeso molecolare:306.36WP1066
CAS:WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formula:C17H14BrN3OPurezza:98.92% - 99.73%Colore e forma:SolidPeso molecolare:356.22AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formula:C19H23N7O2Purezza:99.83% - 99.98%Colore e forma:SolidPeso molecolare:381.43Decernotinib
CAS:Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formula:C18H19F3N6OPurezza:99.28% - >99.99%Colore e forma:SolidPeso molecolare:392.38Ref: TM-T2636
1mg35,00€2mg50,00€5mg74,00€10mg104,00€25mg207,00€50mg311,00€100mg472,00€1mL*10mM (DMSO)84,00€GDC-0214
CAS:GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Formula:C28H28ClF2N9O3Purezza:99.75%Colore e forma:SolidPeso molecolare:612.03Ref: TM-T9826
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)259,00€Fedratinib
CAS:Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.Formula:C27H36N6O3SPurezza:97.31% - 99.96%Colore e forma:SolidPeso molecolare:524.68Ref: TM-T1995
1g625,00€5mg49,00€10mg69,00€50mg113,00€100mg134,00€200mg216,00€500mg472,00€1mL*10mM (DMSO)57,00€RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Formula:C17H14Cl2N6OPurezza:97.94%Colore e forma:SolidPeso molecolare:389.24Deucravacitinib
CAS:Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.Formula:C20H19D3N8O3Purezza:98.52% - >99.99%Colore e forma:SolidPeso molecolare:425.46Ref: TM-T14687
1mg59,00€5mg144,00€10mg261,00€25mg410,00€50mg607,00€100mg863,00€1mL*10mM (DMSO)158,00€
