JAK
Gli inibitori della Janus chinasi (JAK) sono composti che prendono di mira la via di segnalazione JAK-STAT, coinvolta nella crescita cellulare, nella risposta immunitaria e nell'angiogenesi. Inibendo JAK, questi composti possono ridurre la segnalazione che porta alla formazione di nuovi vasi sanguigni nei tumori, inibendo così la crescita tumorale. Gli inibitori di JAK sono importanti nel trattamento del cancro e delle malattie infiammatorie. Presso CymitQuimica, offriamo una vasta gamma di inibitori di JAK di alta qualità per supportare la tua ricerca in oncologia, immunologia e angiogenesi.
Trovati 246 prodotti di "JAK"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Tyrosine Kinase Inhibitor Library
<p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>Colore e forma:Odour SolidJAK3-IN-15
<p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>Colore e forma:Odour SolidKinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Colore e forma:Odour SolidJAK1/TYK2-IN-1
CAS:JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Formula:C18H20F3N7OColore e forma:SolidPeso molecolare:407.401TYD-68
<p>TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.</p>Colore e forma:Odour SolidFDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidS-Ruxolitinib
CAS:<p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>Formula:C17H18N6Purezza:98%Colore e forma:SolidPeso molecolare:306.37JAK-2/3-IN-1
CAS:JAK-2/3-IN-1 inhibits JAK-2/3 isoforms with sub-250 nM Ki; from US patent US8163732B2.Formula:C20H12ClN3OColore e forma:SolidPeso molecolare:345.79SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formula:C36H36N10O5Colore e forma:SolidPeso molecolare:688.74Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formula:C63H107N19O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1514.77Tyk2-IN-22
CAS:Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formula:C16H16ClN5O2Colore e forma:SolidPeso molecolare:345.78DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Colore e forma:SolidPeso molecolare:525.6Atinvicitinib
CAS:Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Formula:C16H17FN6O3Purezza:99.36%Colore e forma:SolidPeso molecolare:360.35Ifidancitinib
CAS:Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formula:C20H18FN5O3Purezza:98.05%Colore e forma:SolidPeso molecolare:395.39WHI-P154
CAS:Formula:C16H14BrN3O3Purezza:>98.0%(HPLC)Colore e forma:White to Yellow to Orange powder to crystalPeso molecolare:376.21Itacitinib adipate
CAS:Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Formula:C32H33F4N9O5Colore e forma:SolidPeso molecolare:699.66WHI-P180 Hydrochloride
CAS:Formula:C16H15N3O3·HClPurezza:>97.0%(T)(HPLC)Colore e forma:White to Light gray to Light yellow powder to crystalPeso molecolare:333.77CHZ868
CAS:<p>CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.</p>Formula:C22H19F2N5O2Purezza:99.38%Colore e forma:SolidPeso molecolare:423.42Ilunocitinib
CAS:Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Formula:C17H17N7O2SPurezza:99.88%Colore e forma:SolidPeso molecolare:383.43Fedratinib hydrochloride hydrate
CAS:Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.Formula:C27H40Cl2N6O4SPurezza:98.96% - 99.87%Colore e forma:SolidPeso molecolare:615.61
