JNK
Le JNK (c-Jun N-terminal kinases) sono un sottogruppo della famiglia MAPK che rispondono a stimoli di stress, come citochine, radiazioni ultraviolette e shock termico, e sono coinvolte nel controllo dell'apoptosi, dell'infiammazione e delle risposte immunitarie. La segnalazione JNK è cruciale per la regolazione delle risposte cellulari allo stress ed è stata implicata in varie malattie, tra cui disturbi neurodegenerativi, cancro e condizioni infiammatorie. Presso CymitQuimica, offriamo una gamma di modulatori della via JNK per supportare la tua ricerca sulla segnalazione dello stress, l'apoptosi e la patologia delle malattie.
Trovati 105 prodotti di "JNK"
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SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurezza:99.38% - 99.71%Colore e forma:SolidPeso molecolare:490.56Ref: TM-T16927
1mg52,00€5mg103,00€10mg160,00€25mg304,00€50mg550,00€100mg882,00€500mg1.768,00€1mL*10mM (DMSO)114,00€SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Formula:C29H25FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:512.53BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formula:C15H12ClN5OPurezza:98.09%Colore e forma:SolidPeso molecolare:313.74TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFormula:C17H15F3N2O4Colore e forma:SolidPeso molecolare:368.31SX 011
CAS:SX 011 is a p38α inhibitor.Formula:C26H27ClFN3O3Purezza:98%Colore e forma:SolidPeso molecolare:483.96GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Formula:C15H12ClFN6OSPurezza:98%Colore e forma:SolidPeso molecolare:378.81J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C17H9ClFN3O2SPurezza:99.90%Colore e forma:SolidPeso molecolare:373.79ZG-10
CAS:ZG-10 (JNK-IN-2) is an inhibitor of JNK, blocking JNK1, JNK2, and JNK3, and is used in studies of SARS-CoV-2 virus infection.Formula:C28H27N7O2Purezza:99.41% - 99.91%Colore e forma:SolidPeso molecolare:493.56JNK3 inhibitor-4
CAS:<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Formula:C28H27N7OColore e forma:SolidPeso molecolare:477.56SR 3576
CAS:JNK3 inhibitor, potent and selectiveFormula:C27H27N5O5Purezza:98%Colore e forma:SolidPeso molecolare:501.53JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formula:C24H22N6SColore e forma:SolidPeso molecolare:426.54JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formula:C12H11NO3S2Purezza:98.82%Colore e forma:SolidPeso molecolare:281.35JNK3 inhibitor-1
CAS:JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Formula:C21H17ClFN5O2SColore e forma:SolidPeso molecolare:457.91TC ASK 10
CAS:TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Formula:C21H23Cl2N5OPurezza:99.86%Colore e forma:SolidPeso molecolare:432.35Ref: TM-T13099
1mg34,00€5mg90,00€10mg131,00€25mg250,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)90,00€JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purezza:98%Colore e forma:SolidPeso molecolare:467.52Ezatiostat hydrochloride
CAS:Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.Formula:C27H36ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:566.11Ref: TM-T22776
2mg58,00€5mg82,00€10mg120,00€25mg200,00€50mg306,00€100mg517,00€200mg777,00€500mg1.165,00€1mL*10mM (DMSO)118,00€JNK-1-IN-4
CAS:JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA). JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.Formula:C22H25BrN6O3Colore e forma:SolidPeso molecolare:501.38p38 Kinase inhibitor 8
CAS:p38 Kinase inhibitor 8 (Compound CCLXXVIII) is an orally active inhibitor targeting p38β and JNK2α2, with IC50 values of 6.3 nM and 53.6 nM, respectively. It has demonstrated anti-inflammatory effects in a rat model of collagen-induced arthritis.Formula:C22H21FN6O2Colore e forma:SolidPeso molecolare:420.44PT109
CAS:PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.Formula:C23H31N3OS2Colore e forma:SolidPeso molecolare:429.64JD123
CAS:JD123 inhibits the activity of JNK1 and the expression of cJun (1-135). It is an ATP-competitive inhibitor specific to p38-γ MAPK and has no effect on ERK1, ERK2, p38-α, p38-β, and p38-δ.Formula:C12H11N5S2Colore e forma:SolidPeso molecolare:289.379
