JNK
Le JNK (c-Jun N-terminal kinases) sono un sottogruppo della famiglia MAPK che rispondono a stimoli di stress, come citochine, radiazioni ultraviolette e shock termico, e sono coinvolte nel controllo dell'apoptosi, dell'infiammazione e delle risposte immunitarie. La segnalazione JNK è cruciale per la regolazione delle risposte cellulari allo stress ed è stata implicata in varie malattie, tra cui disturbi neurodegenerativi, cancro e condizioni infiammatorie. Presso CymitQuimica, offriamo una gamma di modulatori della via JNK per supportare la tua ricerca sulla segnalazione dello stress, l'apoptosi e la patologia delle malattie.
Trovati 104 prodotti di "JNK"
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TOMATIDINE HYDROCHLORIDE
CAS:Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Formula:C27H46ClNO2Purezza:99.75% - ≥95%Colore e forma:SolidPeso molecolare:452.11Actein
CAS:Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Formula:C37H56O11Purezza:≥98%Colore e forma:Brown PowderPeso molecolare:676.83Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purezza:98% - 99.5%Colore e forma:SolidPeso molecolare:855.02Ro 31-8220 Mesylate
CAS:Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Formula:C25H23N5O2S·CH4O3SPurezza:98.79% - 99.02%Colore e forma:SolidPeso molecolare:553.65Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formula:C21H28O2Purezza:99.4% - 99.8%Colore e forma:Light Yellow PowderPeso molecolare:312.45JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Formula:C28H27N7O2Purezza:98.02% - 99.53%Colore e forma:SolidPeso molecolare:493.56CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formula:C22H25ClN6OPurezza:99.71% - ≥95%Colore e forma:SolidPeso molecolare:424.93JIP-1 (153-163) acetate(438567-88-5 free base)
JNK peptide inhibitor. Mimics JIP-1 residues 153-163. Micromolar affinity, little effect on p38, ERK.Formula:C63H108N20O16Purezza:92.89%Colore e forma:SolidPeso molecolare:1401.65Ro 31-8220
CAS:Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.Formula:C25H23N5O2SColore e forma:SolidPeso molecolare:457.55Bentamapimod
CAS:<p>Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.</p>Formula:C25H23N5O2SPurezza:97.04% - 99.92%Colore e forma:SolidPeso molecolare:457.55Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formula:C41H68O14Purezza:99% - 99.84%Colore e forma:Hydroscopic Brown Or Yellow PowderPeso molecolare:784.97JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Formula:C29H29N7O2Purezza:99.24% - >99.99%Colore e forma:SolidPeso molecolare:507.59Juglanin
CAS:Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.Formula:C20H18O10Purezza:98.8% - 99.33%Colore e forma:SolidPeso molecolare:418.35D-JNKI-1 acetate
D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.Formula:C166H290N66O42Purezza:99.48%Colore e forma:SolidPeso molecolare:3882.5TRi-1
CAS:TRi-1 irreversibly inhibits TXNRD1 (IC50: 12 nM) with low mitochondrial toxicity for cancer treatment.Formula:C12H9ClN2O5SPurezza:97.14%Colore e forma:SolidPeso molecolare:328.73IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Formula:C20H11N3O3Purezza:≥98%Colore e forma:SolidPeso molecolare:341.32Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formula:C16H11N3O2Purezza:98.34%Colore e forma:SolidPeso molecolare:277.28IQ-1S free acid
CAS:<p>IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.</p>Formula:C15H9N3OPurezza:97.92% - 99.05%Colore e forma:SolidPeso molecolare:247.25Taurochenodeoxycholic acid sodium
CAS:Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Formula:C26H44NNaO6SPurezza:98.23% - 99.56%Colore e forma:White To Off-White PowderPeso molecolare:521.68Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurezza:99.54% - ≥95%Colore e forma:White SolidPeso molecolare:327.83CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Formula:C16H27N5O2Purezza:99.96%Colore e forma:SolidPeso molecolare:321.42Esculentoside H
CAS:Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Formula:C48H76O21Purezza:98.04% - 99.3%Colore e forma:SolidPeso molecolare:989.1TCS JNK 5a
CAS:TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).Formula:C20H16N2OSPurezza:99.22% - 99.51%Colore e forma:SolidPeso molecolare:332.42Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Formula:C48H82O18Purezza:99.12% - >99.99%Colore e forma:White PowderPeso molecolare:947.15WHI-P258
CAS:WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formula:C16H15N3O2Purezza:99.66% - 99.92%Colore e forma:SolidPeso molecolare:281.31Tomatidine
CAS:<p>Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.</p>Formula:C27H45NO2Purezza:99.94% - 99.98%Colore e forma:SolidPeso molecolare:415.65Sesamolin
CAS:Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.Formula:C20H18O7Purezza:98.77% - 99.04%Colore e forma:SolidPeso molecolare:370.35Pamapimod
CAS:Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Formula:C19H20F2N4O4Purezza:99.52% - 99.99%Colore e forma:SolidPeso molecolare:406.38SX 011
CAS:SX 011 is a p38α inhibitor.Formula:C26H27ClFN3O3Purezza:98%Colore e forma:SolidPeso molecolare:483.96SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurezza:99.38% - 99.71%Colore e forma:SolidPeso molecolare:490.56SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Formula:C29H25FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:512.53SR 3576
CAS:JNK3 inhibitor, potent and selectiveFormula:C27H27N5O5Purezza:98%Colore e forma:SolidPeso molecolare:501.53JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formula:C24H22N6SColore e forma:SolidPeso molecolare:426.54JNK3 inhibitor-4
CAS:<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Formula:C28H27N7OColore e forma:SolidPeso molecolare:477.56BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formula:C15H12ClN5OPurezza:98.09%Colore e forma:SolidPeso molecolare:313.74ZG-10
CAS:ZG-10 (JNK-IN-2) is an inhibitor of JNK, blocking JNK1, JNK2, and JNK3, and is used in studies of SARS-CoV-2 virus infection.Formula:C28H27N7O2Purezza:99.41% - 99.91%Colore e forma:SolidPeso molecolare:493.56TOPK-p38/JNK-IN-1
CAS:TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NOFormula:C17H15F3N2O4Colore e forma:SolidPeso molecolare:368.31J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C17H9ClFN3O2SPurezza:99.90%Colore e forma:SolidPeso molecolare:373.79GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Formula:C15H12ClFN6OSPurezza:98%Colore e forma:SolidPeso molecolare:378.81JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formula:C12H11NO3S2Purezza:98.82%Colore e forma:SolidPeso molecolare:281.35JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purezza:98%Colore e forma:SolidPeso molecolare:467.52JNK3 inhibitor-1
CAS:JNK3 inhibitor-1: potent, selective, IC50 of 0.005 μM, orally bioavailable, brain-penetrant.Formula:C21H17ClFN5O2SColore e forma:SolidPeso molecolare:457.91Ezatiostat hydrochloride
CAS:Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.Formula:C27H36ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:566.11TC ASK 10
CAS:TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Formula:C21H23Cl2N5OPurezza:99.86%Colore e forma:SolidPeso molecolare:432.35JNK-IN-21
CAS:JNK-IN-21 (Compound 62) is an inhibitor of JNK-1.Formula:C19H16N2O2SColore e forma:SolidPeso molecolare:336.408JNK-1-IN-5
CAS:JNK-1-IN-5 (Compound 14) is a potent JNK1 inhibitor with sub-nanomolar efficacy. It effectively inhibits TGF-β-induced epithelial-mesenchymal transition and shows promise for research targeting JNK1 as an anti-pulmonary fibrosis agent.Formula:C23H21BrN6O3Colore e forma:SolidPeso molecolare:509.355JD118
CAS:<p>JD118 is an inhibitor of JNK. It effectively suppresses the activity of JNK1 and the expression of cJun (1 - 135).</p>Formula:C13H12N4S2Colore e forma:SolidPeso molecolare:288.391JNK-1-IN-4
CAS:JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA). JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.Formula:C22H25BrN6O3Colore e forma:SolidPeso molecolare:501.38JD123
CAS:<p>JD123 inhibits the activity of JNK1 and the expression of cJun (1-135). It is an ATP-competitive inhibitor specific to p38-γ MAPK and has no effect on ERK1, ERK2, p38-α, p38-β, and p38-δ.</p>Formula:C12H11N5S2Colore e forma:SolidPeso molecolare:289.379
