MNK
Le MNK (MAPK-interacting kinases) sono un gruppo di chinasi che interagiscono con le MAPK, in particolare ERK e p38, per regolare la sintesi proteica fosforilando il fattore di iniziazione eucariotico 4E (eIF4E). La segnalazione MNK svolge un ruolo nelle risposte cellulari allo stress, nell'infiammazione e nella progressione del cancro. Il targeting delle MNK è una strategia emergente nella terapia del cancro e nei trattamenti anti-infiammatori. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di MNK per supportare la tua ricerca sulla regolazione della sintesi proteica, oncologia e infiammazione.
Trovati 13 prodotti di "MNK"
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ETC-206
CAS:<p>ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).</p>Formula:C25H20N4O2Purezza:99.72% - 99.79%Colore e forma:SolidPeso molecolare:408.45HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Colore e forma:Odour SolidMNK-IN-4
MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor used in treating acute spleen injury related to sepsis.Formula:C15H17N5Peso molecolare:267.1484NUCC-0200808
NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.Colore e forma:Odour SolidCGP 57380
CAS:CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-likeFormula:C11H9FN6Purezza:98.49%Colore e forma:SolidPeso molecolare:244.23Tomivosertib
CAS:Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.Formula:C17H20N6O2Purezza:97.34% - 99.72%Colore e forma:SolidPeso molecolare:340.38Tomivosertib HCl
CAS:Tomivosertib (eFT508) is a MNK1/2 inhibitor that blocks eIF4E phosphorylation, hindering tumor growth and immune signaling.Formula:C17H21ClN6O2Colore e forma:SolidPeso molecolare:376.845SLV-2436
CAS:SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).Formula:C19H15ClN4OPurezza:98.56%Colore e forma:SolidPeso molecolare:350.8HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purezza:99.59%Colore e forma:SolidPeso molecolare:377.83ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Formula:C24H19N5O2Colore e forma:SolidPeso molecolare:409.44MNK1/2-IN-5
CAS:MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.Formula:C17H16N4O2Purezza:98.04%Colore e forma:SolidPeso molecolare:308.33DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Formula:C16H19N3OSPurezza:99.85%Colore e forma:SolidPeso molecolare:301.41MNK inhibitor 9
CAS:<p>MNK inhibitor 9 potently blocks MNK1/2 (IC50: 0.003 µM each), is cell-permeable, and useful for tumor research.</p>Formula:C25H29N9OColore e forma:SolidPeso molecolare:471.56
