MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
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YN14
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with lowPurezza:98%Colore e forma:Odour SolidBI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formula:C47H62N8O4SColore e forma:SolidPeso molecolare:835.11KRAS G12C inhibitor 69
KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.Formula:C29H29ClF3N5O3Colore e forma:SolidPeso molecolare:588.02Z16078526
CAS:<p>Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.</p>Formula:C18H17N3O4SPurezza:98.93%Colore e forma:SolidPeso molecolare:371.41Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formula:C13H11F3N2OSColore e forma:SolidPeso molecolare:300.3HSND80
HSND80 (Compound 1) is an orally active MNK/p70S6K inhibitor, exhibiting a Kd value of 44 nM for MNK1 and 4 nM for MNK2. The residence time of HSND80 on MNK1 and MNK2 is 45 minutes and 58 minutes, respectively. HSND80 effectively inhibits non-small cell lung cancer (NSCLC) both in vitro and in vivo, and suppresses the growth of triple-negative breast cancer (TNBC) cells in vitro.Colore e forma:Odour SolidU0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFormula:C8H10N4S2Purezza:98%Colore e forma:SolidPeso molecolare:226.32PROTAC K-Ras Degrader-3
CAS:PROTAC K-Ras Degrader-3 is a PROTAC degrader targeting K-Ras, exhibiting a DC50 value of ≤ 1 nM against SW620 KRAS G12D and a GI50 value of ≤ 10 nM in inhibiting the growth of SW620 3D cells. It is used in cancer research.Formula:C57H67F2N9O6Colore e forma:SolidPeso molecolare:1012.20Ras Inhibitory Peptide
CAS:<p>Sos1, a GEF, activates ERK by converting Ras-GDP to Ras-GTP via Grb2. The PVPPR peptide inhibits this by blocking Sos1/Grb2 binding.</p>Formula:C53H91N19O11Colore e forma:SolidPeso molecolare:1170.433PROTAC SOS1 degrader-8
CAS:PROTA CSOS1 degrader-8 (Compd 1) acts as a PROTAC degrader targeting SOS1.Formula:C50H60ClN11O4Peso molecolare:914.54HPK1-IN-4
CAS:<p>HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.</p>Formula:C23H26N6O3Purezza:97.2%Colore e forma:SolidPeso molecolare:434.49Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formula:C19H30O3Colore e forma:SolidPeso molecolare:306.44KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formula:C32H37ClN8O2Colore e forma:SolidPeso molecolare:601.15ZZ151
ZZ151 is an effective and selective SOS1 PROTAC with in vivo anti-tumor efficacy against KRAS-mutant cancers. This compound induces rapid and specific degradation of SOS1 and exhibits strong anti-proliferative activity against a wide range of KRAS mutation-driven cancer cells. In murine xenograft models with KRASG12D and G12V mutations, ZZ151 demonstrates superior anticancer activity. It represents a promising lead compound for developing new chemotherapeutic agents targeting KRAS mutations.Formula:C54H68F3N9O6SColore e forma:SolidPeso molecolare:1028.23SW083688
CAS:SW083688 is a potent and highly selective inhibitor of Thousand-And-One Kinase 2 (TAOK2) with an IC 50 value of 1.3 µmol/L.Formula:C23H25N3O5SColore e forma:SolidPeso molecolare:455.53NK7-902
NK7-902 is a CRBN molecular glue degrader of NEK7. It fully degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. NK7-902 results in profound and lasting degradation of NEK7, but only temporarily blocks NLRP3 inflammasome activation in non-human primates via oral administration. The compound demonstrates activity in mouse systems.Colore e forma:Odour SolidMRTF-A-IN-1
<p>MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.</p>Formula:C22H21N3Colore e forma:SolidPeso molecolare:327.42PROTAC SOS1 degrader-4
PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1].Formula:C53H65ClN8O7SPurezza:98%Colore e forma:SolidPeso molecolare:993.65Vacquinol-1
CAS:Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Formula:C21H21ClN2OPurezza:99.92%Colore e forma:SolidPeso molecolare:352.86R 115777
CAS:<p>R 115777 is an inhibitor of farnesyl transferase.</p>Formula:C27H22Cl2N4OPurezza:98%Colore e forma:SolidPeso molecolare:489.40
