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MAPK

MAPK

Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.

Trovati 894 prodotti di "MAPK"

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  • SCH 51344
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    SCH 51344

    CAS:
    SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].
    Formula:C16H20N4O3
    Colore e forma:Solid
    Peso molecolare:316.36

    Ref: TM-T21676

  • BAY-846
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    BAY-846

    CAS:
    BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.
    Formula:C19H13F4IN4O4S
    Colore e forma:Solid
    Peso molecolare:596.29

    Ref: TM-T70133

  • 3,4-Dephostatin
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    3,4-Dephostatin

    CAS:
    3,4-Dephostatin is an inhibitor of the interactions of CFTR-associated ligand (CAL) and PSD-95/Dlg1/ZO-1 (PDZ) domain.
    Formula:C7H8N2O3
    Colore e forma:Solid
    Peso molecolare:168.15

    Ref: TM-T70232

  • LX-3
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    LX-3

    CAS:
    LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.
    Formula:C20H13BrN4OS
    Colore e forma:Solid
    Peso molecolare:437.31

    Ref: TM-T69321

  • Spiclomazine HCl
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    Spiclomazine HCl

    CAS:
    Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.
    Formula:C22H25Cl2N3OS2
    Colore e forma:Solid
    Peso molecolare:482.49

    Ref: TM-T34695

  • KRAS G12C inhibitor 47
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    KRAS G12C inhibitor 47

    CAS:
    KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.
    Formula:C30H28ClFN4O3
    Colore e forma:Solid
    Peso molecolare:547.02

    Ref: TM-T63863

  • SOS1-IN-3
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    SOS1-IN-3

    CAS:
    SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.
    Formula:C21H21F3N4O
    Colore e forma:Solid
    Peso molecolare:402.41

    Ref: TM-T61963

  • SOS1 activator 1
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    SOS1 activator 1

    CAS:
    SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).
    Formula:C26H32ClFN6
    Colore e forma:Solid
    Peso molecolare:483.02

    Ref: TM-T63201

  • PF-04880594
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    PF-04880594

    CAS:
    PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].
    Formula:C19H16F2N8
    Colore e forma:Solid
    Peso molecolare:394.38

    Ref: TM-T21602

  • Ras modulator-1
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    Ras modulator-1

    CAS:
    Ras modulator-1 is a modulator of Ras.
    Formula:C29H21N5O4S
    Colore e forma:Solid
    Peso molecolare:535.57

    Ref: TM-T72774

  • KRAS G12C inhibitor 48
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    KRAS G12C inhibitor 48

    KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.
    Formula:C36H39ClN8O2
    Colore e forma:Solid
    Peso molecolare:651.2

    Ref: TM-T72348

  • Cuspin-1
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    Cuspin-1

    CAS:
    Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.
    Formula:C13H10BrNO
    Colore e forma:Solid
    Peso molecolare:276.13

    Ref: TM-T35594

  • RMM-46
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    RMM-46

    CAS:
    <p>RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.</p>
    Formula:C24H26N4O5
    Purezza:98.89%
    Colore e forma:Solid
    Peso molecolare:450.49

    Ref: TM-T26103

  • B-Raf IN 7
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    B-Raf IN 7

    CAS:
    "B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."
    Formula:C15H16N6O3
    Colore e forma:Solid
    Peso molecolare:328.33

    Ref: TM-T60933

  • KRAS G12C inhibitor 31
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    KRAS G12C inhibitor 31

    CAS:
    KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.
    Formula:C25H22ClFN6O3
    Colore e forma:Solid
    Peso molecolare:508.93

    Ref: TM-T63502

  • 6-T-GDP
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    6-T-GDP

    CAS:
    6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.
    Formula:C10H15N5O10P2S
    Colore e forma:Solid
    Peso molecolare:459.27

    Ref: TM-T88704

  • GDC-0879
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    GDC-0879

    CAS:
    GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.
    Formula:C19H18N4O2
    Purezza:99.62%
    Colore e forma:Solid
    Peso molecolare:334.37

    Ref: TM-T6320

  • mSIRK
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    mSIRK

    CAS:
    mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.
    Formula:C93H150N20O25
    Purezza:99.26%
    Colore e forma:Solid
    Peso molecolare:1948.31

    Ref: TM-T80548

  • Tpl2-IN-I
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    Tpl2-IN-I

    CAS:
    Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.
    Formula:C21H14ClFN6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:404.83

    Ref: TM-T26284

  • NSC1011
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    NSC1011

    CAS:
    NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).
    Formula:C23H18N2O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:370.4

    Ref: TM-T28201