MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 894 prodotti di "MAPK"
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UR13870
CAS:<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Formula:C24H16F2N4Purezza:99.18% - >99.99%Colore e forma:SolidPeso molecolare:398.41p38 MAPK Inhibitor
CAS:p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). It inhibits senescence induced by the oncogene RAS.Formula:C20H13ClFN3OPurezza:99.91%Colore e forma:SolidPeso molecolare:365.79EO-1606
CAS:<p>EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis.</p>Formula:C21H17ClFNOPurezza:98.28% - 98.84%Colore e forma:SolidPeso molecolare:353.82BI-2852
CAS:BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Formula:C31H28N6O2Purezza:98.98%Colore e forma:SolidPeso molecolare:516.59(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purezza:98.09%Colore e forma:SolidPeso molecolare:304.38ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Formula:C20H16N4O2Purezza:99.71% - 99.95%Colore e forma:SolidPeso molecolare:344.37RMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formula:C22H25ClF3N5O3Purezza:97.84%Colore e forma:SolidPeso molecolare:499.91GNE 220
CAS:GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Formula:C25H26N8Purezza:98%Colore e forma:SolidPeso molecolare:438.53HPK1-IN-12
CAS:HPK1-IN-12 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Formula:C25H24FN5O2Colore e forma:SolidPeso molecolare:445.49ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFormula:C31H32ClN7O3Purezza:98%Colore e forma:SolidPeso molecolare:586.08SOS1-IN-4
CAS:SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.Formula:C24H29F2N4O2PColore e forma:SolidPeso molecolare:474.48KRAS G12C inhibitor 35
CAS:KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).Formula:C31H27ClF2N6O3Colore e forma:SolidPeso molecolare:605.03KRAS G12C inhibitor 21
CAS:KRAS G12C inhibitor 21 is a KRAS G12C inhibitor.Formula:C34H30ClN3O4Colore e forma:SolidPeso molecolare:580.07XRP44X
CAS:XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Formula:C21H21ClN4OPurezza:99.67%Colore e forma:SolidPeso molecolare:380.87KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Formula:C31H33ClFN7O2Purezza:98%Colore e forma:SolidPeso molecolare:590.09KRAS G12C inhibitor 25
CAS:KRAS G12C inhibitor 25 blocks SOS1-mediated GDP/GTP swap in KRAS-G12C mutants; IC50: 0.48 nM (WO2021216770A1, comp. 3).Formula:C32H41N7O2Colore e forma:SolidPeso molecolare:555.71KRAS G12C inhibitor 58
CAS:KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].Formula:C51H64ClF4N9O8SPurezza:98%Colore e forma:SolidPeso molecolare:1074.62HPK1-IN-33
CAS:HPK1-IN-33 inhibits HPK1 with 1.7 nM potency, reduces IL-2 in Jurkat cells with 286 nM EC50, and is less effective in HPK1 KO cells.Formula:C18H16ClFN6Colore e forma:SolidPeso molecolare:370.81KRAS G12C inhibitor 53
CAS:KRAS G12C inhibitor 53 (Compound 1) is a KRAS G12C inhibitor.Formula:C21H14ClF2N5O2Colore e forma:SolidPeso molecolare:441.82AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selectiveFormula:C29H28ClN5OPurezza:98%Colore e forma:SolidPeso molecolare:498.02
