MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 892 prodotti di "MAPK"
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KRAS G12C inhibitor 35
CAS:KRAS G12C inhibitor 35 targets KRAS G12C in cancer research (CN112920183A, compound 3).Formula:C31H27ClF2N6O3Colore e forma:SolidPeso molecolare:605.03SOS1-IN-4
CAS:SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions.Formula:C24H29F2N4O2PColore e forma:SolidPeso molecolare:474.48AZD4747
CAS:<p>AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the study of pancreatic and colorectal adenocarcinoma.</p>Formula:C24H22ClFN2O3Purezza:99.36%Colore e forma:SolidPeso molecolare:440.89ZG1077
CAS:ZG1077, a covalent KRAS G12C inhibitor, is utilized in non-small cell lung cancer (NSCLC) research.Formula:C33H33F2N5O5SColore e forma:SolidPeso molecolare:649.71HPK1-IN-27
CAS:HPK1-IN-27 inhibits HPK1 (MAP4K1), a kinase with potential for cancer treatment, per patent WO2019016071A1, compound 38.Formula:C26H23F3N4O4Colore e forma:SolidPeso molecolare:512.48KRAS inhibitor-18
CAS:KRAS inhibitor-18 targets KRAS G12C; IC50: 4.74 μM. Inhibits p-ERK in cancer cells. Promising for pancreatic, colorectal, lung cancer research.Formula:C20H15ClF3N3O2SColore e forma:SolidPeso molecolare:453.87SOS1-IN-16
CAS:SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 ofFormula:C30H31F3N4O3Purezza:98%Colore e forma:SolidPeso molecolare:552.59KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Formula:C24H19ClF2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:484.88CMP3a
CAS:CMP3a, a NEK2 inhibitor, hinders GBM in mice and enhances radiotherapy by disrupting EZH2.Formula:C28H27F3N6O2SColore e forma:SolidPeso molecolare:568.61SOS1-IN-14
CAS:SOS1-IN-14 是选择性的、有效的、口服具有活力的 SOS1 抑制剂 (IC50: 3.9 nM)。SOS1-IN-14 能够利用 P-糖蛋白介导的外排机制在肠道内被吸收。SOS1-IN-14 能够用于 KRAS 突变的癌症的研究，且抑瘤效果比 BI-3406 好。Formula:C29H29F3N6O2Colore e forma:SolidPeso molecolare:550.57GGTI-297
CAS:GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase).Formula:C26H31N3O3SColore e forma:SolidPeso molecolare:465.61ERK1/2 inhibitor 7
CAS:ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Formula:C23H22FN7OSColore e forma:SolidPeso molecolare:463.53HPK1-IN-9
CAS:HPK1-IN-9: Potent MAP4K family kinase inhibitor targeting hematopoietic progenitor cells; potential in HPK1 diseases. (Patent WO2021213317A1)Formula:C30H33N7O2Colore e forma:SolidPeso molecolare:523.63KRAS G12C mutant protein inhibitor A-1
CAS:KRAS G12C mutant protein inhibitor A-1 can be used in studies about Ras.Formula:C31H26ClF4N7O2Colore e forma:SolidPeso molecolare:640.03SOS1-IN-8
CAS:SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM).Formula:C24H26F3N3O4Colore e forma:SolidPeso molecolare:477.48Ras inhibitor 134
CAS:Ras inhibitor 134 can be used in studies about Ras.Formula:C23H21ClFN5O3Colore e forma:SoildPeso molecolare:469.9KRAS inhibitor-12
CAS:KRAS inhibitor-12 blocks KRAS G12C (IC50: 0.537 μM) and p-ERK in cancer cells; promising for pancreatic, colorectal, lung cancer study.Formula:C19H16Cl2FN5OSColore e forma:SolidPeso molecolare:452.33SOS1-IN-5
CAS:<p>SOS1-IN-5, a potent pyrimidine inhibitor, disrupts RAS-SOS1, blocking KRAS activation.</p>Formula:C26H31F3N4O5Colore e forma:SolidPeso molecolare:536.54KRAS G12C inhibitor 49
CAS:KRAS G12C inhibitor 49 is an orally active KRAS G12C inhibitor that exhibits antitumour effects.Formula:C31H31ClN6O3Colore e forma:SolidPeso molecolare:571.07B-Raf IN 5
CAS:B-Raf IN 5 is a potent inhibitor of the protein kinase B-Raf (IC50: 2.0 nM). B-Raf IN 5 resists rapid metabolism and does not bind to the secondary target PXR.Formula:C23H18ClF3N6O3S2Colore e forma:SolidPeso molecolare:583.01
