MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 892 prodotti di "MAPK"
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pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Formula:C33H32F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:587.63SB 203580 sulfone
CAS:<p>SB 203580 sulfone, an analog of the p38 MAP kinase inhibitor SB 203580, inhibits IL-1 production in monocytes and binds competitively with CSAID binding proteins (CSBP), inhibiting stress response signaling. It exhibits an IC50 of 0.2 μM for IL-1 inhibition and 0.03 μM for CSBP-mediated signaling inhibition [1].</p>Formula:C21H16FN3O2SColore e forma:SolidPeso molecolare:393.43(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Formula:C24H20Cl2FN5O2Purezza:98.73%Colore e forma:SolidPeso molecolare:500.35AZ-TAK1
CAS:"AZ-Tak1 inhibits TAK1 kinase (IC50=0.009mM), reduces p38/ERK levels, and induces apoptosis in Mino, SP53, Jeko cells with increasing efficacy at 0.1-0.5mM."Formula:C25H28FN7O2Colore e forma:SolidPeso molecolare:477.53Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formula:C18H19FN8O2SPurezza:98%Colore e forma:SolidPeso molecolare:430.46HPK1-IN-35
CAS:HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM.Formula:C30H32N8O3SColore e forma:SolidPeso molecolare:584.69Rac1-IN-3
CAS:Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Formula:C21H23N7O2Purezza:98%Colore e forma:SolidPeso molecolare:405.45BI-0474
CAS:<p>BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, for cancer research.</p>Formula:C30H37N9O2SPurezza:99.61%Colore e forma:SolidPeso molecolare:587.74(R)-BDP9066
CAS:(R)-BDP9066 blocks MRCK to curb cancer cell spread, aiding research on diseases like cancer.Formula:C20H24N6Colore e forma:SolidPeso molecolare:348.44KRAS G12C inhibitor 59
CAS:KRAS G12C Inhibitor 59 is a compound with anticancer properties.Formula:C32H39F6N7O5Purezza:98%Colore e forma:SolidPeso molecolare:715.69DT-061
CAS:DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.Formula:C25H23F3N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:520.52KRAS G12C inhibitor 16
CAS:KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.Formula:C24H21ClFN3O3Purezza:97.84%Colore e forma:SolidPeso molecolare:453.89BDP8900
CAS:BDP8900: potent, selective MRCK inhibitor; alters cancer cell shape, reduces mobility and invasion.Formula:C19H23N5SColore e forma:SolidPeso molecolare:353.48KRAS G12C inhibitor 58
CAS:KRAS G12C inhibitor 58 is utilized in cancer research as an inhibitor of the KRAS G12C mutation [1].Formula:C51H64ClF4N9O8SPurezza:98%Colore e forma:SolidPeso molecolare:1074.62RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Formula:C27H28N4O6SColore e forma:SolidPeso molecolare:536.6KRAS G12D modulator-1
CAS:KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFormula:C30H36FN5O4Purezza:98%Colore e forma:SolidPeso molecolare:549.64pan-KRAS-IN-2
CAS:Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12DFormula:C34H34F2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:584.66SB-682330A
CAS:SB-682330A is a Raf kinase inhibitor.Formula:C28H27N3O3Colore e forma:SolidPeso molecolare:453.53Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFormula:C21H21F3IN3O2Purezza:98.00% - 99.71%Colore e forma:SolidPeso molecolare:531.31KRAS G12C inhibitor 17
CAS:KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.Formula:C24H20ClF2N3O3Purezza:98%Colore e forma:SolidPeso molecolare:471.88
