MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
MAP855
CAS:MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.Formula:C28H23ClF2N6O3Colore e forma:SolidPeso molecolare:564.97MLKL-IN-1
MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.Formula:C19H20N2O3Colore e forma:SolidPeso molecolare:324.37INCB159020
CAS:INCB159020 is an orally active inhibitor of KRAS G12D, exhibiting a KRAS G12D SPR value of 2.2 nM. It demonstrates anti-tumor activity.Formula:C37H35ClFN7O2Colore e forma:SolidPeso molecolare:664.171GDC-6036-NH
CAS:GDC-6036-NH is a precursor of compound 17a /b, which is a RAS inhibitor that can be used in cancer research.Formula:C26H30ClF4N7OPurezza:99.84%Colore e forma:SolidPeso molecolare:568.01KRAS G12D inhibitor 12
KRAS G12D inhibitor 12 targets Ras protein for cancer research. (Patent WO2021108683A1, Compound 134)Formula:C23H21ClFN5O3Colore e forma:SolidPeso molecolare:469.9SOS1-IN-10
SOS1-IN-10 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 13 nM).Formula:C22H19F5N4OColore e forma:SolidPeso molecolare:450.4KRAS G12D inhibitor 1
CAS:KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D with an IC 50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1].Formula:C33H32F2N6O2Colore e forma:SolidPeso molecolare:582.64p38-α MAPK-IN-5
CAS:p38-α MAPK-IN-5: potent p38α inhibitor, IC50s: 0.1 nM (α), 0.2 nM (β), 944 nM (γ), 4100 nM (δ); anti-inflammatory, promising for asthma/COPD research.Formula:C37H49N11O2Colore e forma:SolidPeso molecolare:679.86pan-Raf/RTK inhibitor 1
CAS:<p>Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). It exhibits antiproliferative activity against various cancer cell lines and can be utilized in cancer research.</p>Formula:C29H28F3N7O3Colore e forma:SolidPeso molecolare:579.573Refametinib R enantiomer
CAS:<p>Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used</p>Formula:C19H20F3IN2O5SPurezza:99.86%Colore e forma:SolidPeso molecolare:572.34TH-Z816
CAS:TH-Z816 acts as a reversible inhibitor targeting the KRAS(G12D) mutation, exhibiting an IC50 of 14 µM. This compound is utilized in cancer research [1].Formula:C29H38N6OColore e forma:SolidPeso molecolare:486.65Dorrigocin A
CAS:Dorrigocin A, an analog of Migrastatin, inhibits the carboxymethyltransferase involved in Ras processing, reversing the morphology of Ras-transformed NIH/3T3 cells. Dorrigocin A holds potential for research as an anticancer and anti-arthritis agent.Formula:C27H41NO8Colore e forma:SolidPeso molecolare:507.616MRTX849 acid
CAS:MRTX849 acid, used to make PROTAC LC-2, effectively degrades KRAS G12C at 0.25-0.76 μM DC50.Formula:C34H37ClFN7O4Colore e forma:SolidPeso molecolare:662.16KRASG12C IN-12
CAS:KRASG12C IN-12 (compound-1) acts as an inhibitor of KRASG12C. It forms a ternary complex with intracellular CYPA and the activated mutant of KRASG12C.Formula:C29H39N5O6S2Colore e forma:SolidPeso molecolare:617.78KRAS G12D inhibitor 11
CAS:KRAS G12D inhibitor 11 targets KRAS G12D in cancer research (patent WO2021108683A1, compound 52).Formula:C29H38BN5O3Colore e forma:SolidPeso molecolare:515.45SOF-436
CAS:SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.Formula:C15H13F2NO4S2Colore e forma:SolidPeso molecolare:373.395OZO-H
CAS:OZO-H is a GST inhibitor and a potent anticancer derivative of OZO. It releases JNK1 from the GST-JNK1 complex, induces JNK1 phosphorylation, and activates c-Jun in cancer cells.Formula:C8H5NO2SColore e forma:SolidPeso molecolare:179.20KRAS G12D inhibitor 19
CAS:KRAS G12D inhibitor 19 (Compound 7) is used in cancer research [1]. As a specific inhibitor of KRAS G12D, it targets and potentially suppresses this mutation, which is frequently associated with various cancers.Formula:C35H34F2N6O3Colore e forma:SolidPeso molecolare:624.68Dioleyl phosphatidylserine
CAS:Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.Formula:C42H78NO10PColore e forma:SolidPeso molecolare:788.04Nek2/Hec1-IN-3
CAS:Nek2/Hec1-IN-3 (Compound 11-28) is an inhibitor of the Hec1/Nek2 interaction. It disrupts the binding between Nek2 and Hec1 and is applicable for research in tumor diseases.Formula:C16H13N3OSColore e forma:SolidPeso molecolare:295.36
