MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
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JNK-IN-19
CAS:<p>JNK-IN-19 (Compound Q8) is an inhibitor of c-Jun N-terminal kinase, utilized for the treatment and/or prevention of injuries prior to, during, or following surgery.</p>Formula:C22H24F3N6Na2O6PColore e forma:SolidPeso molecolare:602.41Lambertellin
CAS:Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Formula:C14H8O5Colore e forma:SolidPeso molecolare:256.21MNK1 ligand 1
CAS:MNK1ligand 1 (Compound 5) is an MNK1 ligand used in the synthesis of PROTACMNK1 degrader-1.Formula:C15H17N3OSColore e forma:SolidPeso molecolare:287.38SHR2415
SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.Formula:C23H22ClN7O2Colore e forma:SolidPeso molecolare:463.92ABS-752
CAS:ABS-752 is an effective and orally active molecular glue degrader targeting GSPT1 and NEK7. It exhibits cytotoxic properties and reduces the protein expression of GSPT1, SALL4, and NEK7. ABS-752 possesses anticancer activity and shows potential for research in hepatocellular carcinoma.Formula:C14H14FN3O3Colore e forma:SolidPeso molecolare:291.28COTI-219
CAS:COTI-219 is an oral inhibitor of KRAS with antitumor properties [1].Formula:C17H18N6SColore e forma:SolidPeso molecolare:338.43HPK1-IN-55
CAS:<p>HPK1-IN-55 (compound 19) is a selective and orally active inhibitor of hematopoietic progenitor kinase 1 (HPK1) with an IC50 of less than 0.51 nM. It exhibits exceptional kinase selectivity, being over 637 times more selective for HPK1 compared to GCK kinase and over 1022 times compared to LCK. HPK1-IN-55 possesses anti-cancer properties.</p>Formula:C30H34N8O3Colore e forma:SolidPeso molecolare:554.643JNK-IN-21
CAS:<p>JNK-IN-21 (Compound 62) is an inhibitor of JNK-1.</p>Formula:C19H16N2O2SColore e forma:SolidPeso molecolare:336.408KRAS G12C inhibitor 50
CAS:KRAS G12C inhibitor 50 is a KRAS G12C inhibitor (IC50: 46.7 nM).Formula:C31H34N8O2Colore e forma:SolidPeso molecolare:550.65KRAS G12D inhibitor 3
CAS:KRAS G12D Inhibitor 3, a compound targeting the KRAS G12D mutation, demonstrates potent antitumor efficacy with an inhibitory concentration (IC50) of less thanFormula:C34H31ClF3N5O2Colore e forma:SolidPeso molecolare:634.09Sosimerasib
CAS:<p>Sosimerasib is an inhibitor of the kirsten rat sarcoma viral oncogene homolog (KRAS) and exhibits antitumor activity.</p>Formula:C36H39ClFN7O4Colore e forma:SolidPeso molecolare:688.191ADT-1004
CAS:ADT-1004 is an inhibitor of RAS. It can be used for research involving Ras-mediated diseases.Formula:C33H36FN3O6Colore e forma:SoildPeso molecolare:589.65KRAS G12C inhibitor 15
CAS:<p>KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .</p>Formula:C25H21ClF2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:498.91MRTX849 ethoxypropanoic acid
CAS:MRTX849 is a KRAS G12C ligand and PROTAC linker for creating potent LC-2, degrading KRAS G12C with DC50 of 0.25-0.76 μM.Formula:C37H43ClFN7O5Colore e forma:SolidPeso molecolare:720.24HPK1-IN-14
CAS:HPK1-IN-14 is a potent inhibitor of HPK1. HPK1-IN-14 has potential for the study of HPK1-related diseases.Formula:C24H23FN6O2Colore e forma:SolidPeso molecolare:446.48HPK1 ligand-Linker Conjugate 1
CAS:HPK1 ligand-Linker Conjugate 1 is a synthetic target protein ligand-linker compound used in the synthesis of PROTACs, such as PROTACHPK1 Degrader-5. PROTACHPK1 Degrader-5 is a potent and orally active HPK1 PROTAC degrader with anti-tumor activity.Formula:C19H21N3O7SColore e forma:SolidPeso molecolare:435.45CK1δ-IN-9
CAS:CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.Formula:C16H12FN5Colore e forma:SolidPeso molecolare:293.298p38-α MAPK-IN-10
CAS:<p>p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.</p>Formula:C27H34Cl2N6Colore e forma:SolidPeso molecolare:513.505p38-α MAPK-IN-9
CAS:<p>p38-α MAPK-IN-9 (Compound 25a) is a p38-α MAPK inhibitor with a Ki value of 0.057 nM. It effectively inhibits LPS-induced TNFα production in hPBMC cells, exhibiting an IC50 of 18 nM.</p>Formula:C19H20N8O2Colore e forma:SolidPeso molecolare:392.414SML-10-70-1
CAS:SML-10-70-1 is a Novel Active Site Inhibitor of Oncogenic K-Ras G12C.Formula:C25H42ClN7O13P2Colore e forma:SolidPeso molecolare:746.04
