MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
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HPK1-IN-20
CAS:HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).Formula:C26H28N6O2Colore e forma:SolidPeso molecolare:456.55Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Formula:C13H11F3N2OSColore e forma:SolidPeso molecolare:300.3PROTAC K-Ras Degrader-1
CAS:PROTAC K-Ras Degrader-1 is a PROTAC degrader based on the Cereblon E3 ligase ligand, capable of degrading K-Ras.Formula:C53H62N10O10Purezza:98.05%Colore e forma:SolidPeso molecolare:999.12NecroX-2
CAS:<p>NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.</p>Formula:C25H32N4O4S2Purezza:97.12%Colore e forma:SolidPeso molecolare:516.68ERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Formula:C28H31ClFN5O6SColore e forma:SolidPeso molecolare:620.09YN14
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with lowPurezza:98%Colore e forma:Odour SolidU0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFormula:C8H10N4S2Purezza:98%Colore e forma:SolidPeso molecolare:226.32PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Formula:C53H66FIN8O11S2Purezza:98%Colore e forma:SolidPeso molecolare:1201.17MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Colore e forma:SolidPeso molecolare:649.4BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formula:C47H62N8O4SColore e forma:SolidPeso molecolare:835.11Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormula:C18H13N3OSPurezza:99.82%Colore e forma:SolidPeso molecolare:319.38Pan-RAS-IN-6
Pan-RAS-IN-6 (compound 24) serves as a DUSP6 inhibitor, effectively reducing MAPK activation in the NCI-H1373-Luc model (DUSP6). It concurrently exhibits notable tumor growth inhibition and regression in the NSCLC brain metastasis mouse model. The compound displays high selectivity and potent inhibitory effects, particularly on KRAS mutation-associated signaling pathways. It demonstrates varied inhibitory activities against distinct KRAS mutants and their interacting proteins. The IC 50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively.Formula:C46H60N8O5SColore e forma:SolidPeso molecolare:837.08HPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Formula:C26H27N7O2Colore e forma:SolidPeso molecolare:469.54JNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formula:C32H30FN7O3Colore e forma:SolidPeso molecolare:579.62Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formula:C21H21F3IN3O2Purezza:98%Colore e forma:SolidPeso molecolare:531.318KRAS inhibitor-38
CAS:KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formula:C53H68ClF2N9O8SColore e forma:SolidPeso molecolare:1064.68PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Formula:C54H69N11O6SPurezza:98%Colore e forma:SolidPeso molecolare:1000.26KRAS G12C inhibitor 60
<p>KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, and</p>Formula:C31H30F5N7O2Purezza:98%Colore e forma:SolidPeso molecolare:627.61KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formula:C32H37ClN8O2Colore e forma:SolidPeso molecolare:601.1512-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Formula:C18H28O3Purezza:98%Colore e forma:SolidPeso molecolare:292.41
