MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
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(R)-STU104
CAS:(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.Formula:C18H18O4Purezza:98.91% - 99.42%Colore e forma:SolidPeso molecolare:298.33REDX05358
CAS:REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.Formula:C26H21ClN4O3Colore e forma:SolidPeso molecolare:472.92KRAS inhibitor-3
CAS:KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.Formula:C25H27N5OColore e forma:SolidPeso molecolare:413.51Spiclomazine HCl
CAS:Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.Formula:C22H25Cl2N3OS2Colore e forma:SolidPeso molecolare:482.49PF-04880594
CAS:PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].Formula:C19H16F2N8Colore e forma:SolidPeso molecolare:394.38KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.Formula:C36H39ClN8O2Colore e forma:SolidPeso molecolare:651.2KRAS G12C inhibitor 31
CAS:KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.Formula:C25H22ClFN6O3Colore e forma:SolidPeso molecolare:508.93L-167307
CAS:L-167307 is a p38 kinase inhibitor.Formula:C22H17FN2OSPurezza:98%Colore e forma:SolidPeso molecolare:376.45KRAS4b-IN-D14
CAS:KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.Formula:C24H24ClN5O4Colore e forma:SolidPeso molecolare:481.93HPK1-IN-15
CAS:HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.Formula:C24H21ClF3N5Colore e forma:SolidPeso molecolare:471.91KRAS G12D inhibitor 13
CAS:KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).Formula:C31H33F2N7O3Colore e forma:SolidPeso molecolare:589.64KRAS G12C inhibitor 42
CAS:KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)Formula:C33H34FN7O2Colore e forma:SolidPeso molecolare:579.67p38-α MAPK-IN-4
CAS:p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.Formula:C17H13BrN2OColore e forma:SolidPeso molecolare:341.2LCRF-0004
CAS:LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.Formula:C28H18F4N6O2SColore e forma:SolidPeso molecolare:578.54KRAS G12C inhibitor 39
CAS:KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.Formula:C37H43N9O2Colore e forma:SolidPeso molecolare:645.8CBS-3595
CAS:CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.Formula:C18H17FN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:372.42GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C26H21F3N4OColore e forma:SolidPeso molecolare:462.47JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formula:C24H22N6SColore e forma:SolidPeso molecolare:426.54ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Formula:C22H18Cl2N4O2S2Colore e forma:SolidPeso molecolare:505.44JX 401
CAS:JX 401 is a p38α inhibitor.Formula:C21H25NO2SPurezza:98%Colore e forma:SolidPeso molecolare:355.49SB 204900
CAS:SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.Formula:C18H17NO2Colore e forma:SolidPeso molecolare:279.33HPK1-IN-29
CAS:"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."Formula:C26H18F3N5O2Colore e forma:SolidPeso molecolare:489.45DDO3711
CAS:"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."Formula:C42H41N9O6Colore e forma:SolidPeso molecolare:767.83KRAS G12C inhibitor 29
CAS:KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.Formula:C23H21ClFN5O2Colore e forma:SolidPeso molecolare:453.98-CPT-2Me-cAMP, sodium salt
CAS:8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.Formula:C17H16ClN5NaO6PSColore e forma:SolidPeso molecolare:507.82SCH-53870
CAS:SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.Formula:C18H18N2O4SColore e forma:SolidPeso molecolare:358.41KRAS inhibitor-16
CAS:KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.Formula:C20H16Cl2FN3O2SColore e forma:SolidPeso molecolare:452.33SOS1-IN-12
CAS:SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).Formula:C23H26F3N5Colore e forma:SolidPeso molecolare:429.48MTBT
CAS:MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.Formula:C14H11NO2S2Colore e forma:SolidPeso molecolare:289.37ARS-2102
CAS:ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Formula:C28H31ClF2N6O2Colore e forma:SolidPeso molecolare:557.03ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formula:C16H11Cl2FN4O2Colore e forma:SolidPeso molecolare:381.19KRAS inhibitor-15
CAS:KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).Formula:C20H17Cl2FN4OSColore e forma:SolidPeso molecolare:451.34(S)-p38 MAPK Inhibitor III
CAS:(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.Formula:C23H21FN4SColore e forma:SolidPeso molecolare:404.5RAS inhibitor Abd-7
CAS:Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.Formula:C23H25N3O3Colore e forma:SolidPeso molecolare:391.46RAF-IN-1
CAS:RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.Formula:C26H22F3N3O4Colore e forma:SolidPeso molecolare:497.47KRAS inhibitor-4
CAS:KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.Formula:C30H39ClN8OPurezza:98%Colore e forma:SolidPeso molecolare:563.14Anti-inflammatory agent 33
CAS:Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.Formula:C22H15N3O5SColore e forma:SolidPeso molecolare:433.44RSK2-IN-3
CAS:<p>RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.</p>Formula:C24H26N4O5Colore e forma:SolidPeso molecolare:450.49MLKL-IN-5
CAS:MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .Formula:C18H20N6O4SColore e forma:SolidPeso molecolare:416.45HPK1-IN-28
CAS:HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.Formula:C25H22F3N5O4Colore e forma:SolidPeso molecolare:513.47JTP-70902
CAS:<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Formula:C24H21BrFN5O5SColore e forma:SolidPeso molecolare:590.42Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Formula:C26H28BrF3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:565.43p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Formula:C12H4Cl6O4SColore e forma:SolidPeso molecolare:456.94KRAS inhibitor-10
CAS:KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Formula:C30H37N3O5Colore e forma:SolidPeso molecolare:519.63KRAS G12C inhibitor 45
CAS:KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Formula:C32H33F2N5O5SColore e forma:SolidPeso molecolare:637.7JNK3 inhibitor-4
CAS:<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Formula:C28H27N7OColore e forma:SolidPeso molecolare:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Formula:C26H28N6OColore e forma:SolidPeso molecolare:440.54KRAS inhibitor-17
CAS:KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Formula:C21H18Cl2FN3O2SColore e forma:SolidPeso molecolare:466.36BRAF V600E/CRAF-IN-2
CAS:Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Formula:C30H30F3N5O2Colore e forma:SolidPeso molecolare:549.59
