MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
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KRAS4b-PDEδ stabilizer C19
CAS:KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis viaFormula:C18H20Cl2N2O3Colore e forma:SolidPeso molecolare:383.27SCH 51344
CAS:SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].Formula:C16H20N4O3Colore e forma:SolidPeso molecolare:316.36LX-3
CAS:LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.Formula:C20H13BrN4OSColore e forma:SolidPeso molecolare:437.31KRAS G12C inhibitor 47
CAS:KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.Formula:C30H28ClFN4O3Colore e forma:SolidPeso molecolare:547.02SOS1-IN-3
CAS:<p>SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.</p>Formula:C21H21F3N4OColore e forma:SolidPeso molecolare:402.41SOS1 activator 1
CAS:<p>SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).</p>Formula:C26H32ClFN6Colore e forma:SolidPeso molecolare:483.026-T-GDP
CAS:<p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>Formula:C10H15N5O10P2SColore e forma:SolidPeso molecolare:459.27GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formula:C19H18N4O2Purezza:99.62%Colore e forma:SolidPeso molecolare:334.37Tpl2-IN-I
CAS:Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.Formula:C21H14ClFN6Purezza:98%Colore e forma:SolidPeso molecolare:404.83NSC1011
CAS:NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).Formula:C23H18N2O3Purezza:98%Colore e forma:SolidPeso molecolare:370.4AZD6703 free base
CAS:AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).Formula:C24H27N5O2Colore e forma:SolidPeso molecolare:417.5Kobe2601
CAS:Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.Formula:C13H10FN5O4SPurezza:98%Colore e forma:SolidPeso molecolare:351.31GSK329
CAS:GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.Formula:C19H14Cl2F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:472.25HCI-2184
CAS:HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.Formula:C23H28ClN7O2SPurezza:98%Colore e forma:SolidPeso molecolare:502.03GSK649A
CAS:GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.Formula:C15H12ClFN6OSPurezza:98%Colore e forma:SolidPeso molecolare:378.81CP-281384
CAS:CP-281384 is a potent, p38alpha-selective inhibitor.Formula:C18H14F2N4OPurezza:98%Colore e forma:SolidPeso molecolare:340.33RBC6
CAS:RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Formula:C16H14Cl2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:365.21CP-944629
CAS:CP-944629 is a novel, potent, and selective inhibitor of p38alpha.Formula:C19H15F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:372.34BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:282.29(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Formula:C18H16N6S2Colore e forma:SolidPeso molecolare:380.49Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurezza:98.31%Colore e forma:SolidPeso molecolare:454.53PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Formula:C14H22BO4PColore e forma:SolidPeso molecolare:296.11D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Formula:C17H15N5OSColore e forma:SolidPeso molecolare:337.4SW-034538
CAS:SW-034538 is a TAO2 inhibitor (IC 50= 300 nM).Formula:C18H20N4O3S2Colore e forma:SolidPeso molecolare:404.51BSJ-04-122
CAS:BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formula:C15H12ClN5OPurezza:98.09%Colore e forma:SolidPeso molecolare:313.74Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Formula:C13H10BrNOColore e forma:SolidPeso molecolare:276.13CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Formula:C17H12FN3O2Purezza:99.31%Colore e forma:SolidPeso molecolare:309.29BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Formula:C19H13F4IN4O4SColore e forma:SolidPeso molecolare:596.29SR-3306
CAS:SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formula:C28H26N8OPurezza:99.38% - 99.71%Colore e forma:SolidPeso molecolare:490.56GNE-1858
CAS:GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).Formula:C21H26F2N8Purezza:99.36%Colore e forma:SolidPeso molecolare:428.48Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Formula:C18H18N2O4Colore e forma:SolidPeso molecolare:326.35J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C17H9ClFN3O2SPurezza:99.90%Colore e forma:SolidPeso molecolare:373.79TAK1/MAP4K2 inhibitor 1
CAS:TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.Formula:C29H31F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:552.59RMM-46
CAS:<p>RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.</p>Formula:C24H26N4O5Purezza:98.89%Colore e forma:SolidPeso molecolare:450.49LY-2584702 hydrochloride
CAS:<p>Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.</p>Formula:C21H20ClF4N7Purezza:98%Colore e forma:SolidPeso molecolare:481.88MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Formula:C26H26N4O2Purezza:97.48%Colore e forma:SolidPeso molecolare:426.51NSC-70220
CAS:SOS1-IN-1 is an inhibitor of SOS1.Formula:C22H15NO2Purezza:98%Colore e forma:SolidPeso molecolare:325.36MNK1/2-IN-5
CAS:MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.Formula:C17H16N4O2Purezza:98.04%Colore e forma:SolidPeso molecolare:308.33MEK-IN-4
CAS:<p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>Formula:C21H18N4OSPurezza:98.35% - 99.16%Colore e forma:SolidPeso molecolare:374.46Nek2-IN-5
CAS:Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).Formula:C15H12N6OPurezza:98.11%Colore e forma:SolidPeso molecolare:292.3mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purezza:99.26%Colore e forma:SolidPeso molecolare:1948.31BI-2852
CAS:BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Formula:C31H28N6O2Purezza:98.98%Colore e forma:SolidPeso molecolare:516.59RMC-0331
CAS:RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formula:C22H25ClF3N5O3Purezza:97.84%Colore e forma:SolidPeso molecolare:499.91ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Formula:C20H16N4O2Purezza:99.71% - 99.95%Colore e forma:SolidPeso molecolare:344.37JNK-IN-11
CAS:JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formula:C12H11NO3S2Purezza:98.82%Colore e forma:SolidPeso molecolare:281.35MKK7-COV-9
CAS:MKK7-COV-9 is an MKK7 inhibitor that inhibits MKK7-induced protein-protein interactions and interrupts the activation of primary B cells in response to LPS.Formula:C18H16N4O2Purezza:99.73% - 99.83%Colore e forma:SolidPeso molecolare:320.35UR13870
CAS:<p>UR-13870 (Org 48762-0) is a p38 MAPK inhibitor that prevents bone damage in collagen-induced arthritis in mice.</p>Formula:C24H16F2N4Purezza:99.18% - >99.99%Colore e forma:SolidPeso molecolare:398.41DS12881479
CAS:DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].Formula:C16H19N3OSPurezza:99.85%Colore e forma:SolidPeso molecolare:301.41GSK2008607
CAS:<p>GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.</p>Formula:C31H28F3N7O3S2Purezza:99.36%Colore e forma:SolidPeso molecolare:667.72(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purezza:98.09%Colore e forma:SolidPeso molecolare:304.38
