MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti di "MAPK"
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Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Formula:C23H18ClF2N3O3SPurezza:98.53% - 99.36%Colore e forma:SolidPeso molecolare:489.92SGX-523
CAS:<p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>Formula:C18H13N7SPurezza:99% - >99.99%Colore e forma:SolidPeso molecolare:359.41BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Formula:C27H28N4O2Purezza:97.84%Colore e forma:SolidPeso molecolare:440.54AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formula:C28H21N7OSPurezza:98.4% - 99.51%Colore e forma:SolidPeso molecolare:503.58SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formula:C20H21FN4O2Purezza:99.42% - 99.81%Colore e forma:SolidPeso molecolare:368.4sodium lauroyl-α-hydroxyethyl sulfonate
CAS:Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.Formula:C14H27NaO5SPurezza:≥98% - ≥98%Colore e forma:SolidPeso molecolare:330.41APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Formula:C23H21N3O3Colore e forma:SolidPeso molecolare:387.43SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Formula:C24H28N2O9SPurezza:95.65%Colore e forma:SolidPeso molecolare:520.55HPK1-IN-34
CAS:HPK1-IN-34 (Compound 143) is an inhibitor of HPK1 (Haematopoietic progenitor kinase 1) with an IC₅₀ < 0.1 μM, suitable for cancer and immunology research.Formula:C25H28N4O2SPurezza:99.39%Colore e forma:SolidPeso molecolare:448.58B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Formula:C29H24F3N5OPurezza:97.22% - 99.27%Colore e forma:SolidPeso molecolare:515.53CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Formula:C24H15F2N3Purezza:98.79%Colore e forma:SolidPeso molecolare:383.39PF-06260933
CAS:<p>PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.</p>Formula:C16H13ClN4Purezza:99.63% - 99.97%Colore e forma:SolidPeso molecolare:296.75(E/Z)-BIX02188
CAS:BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.Formula:C25H24N4O2Purezza:97.39% - 98.38%Colore e forma:SolidPeso molecolare:412.48DB07268
CAS:<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Formula:C17H15N5O2Purezza:98.2% - 98.91%Colore e forma:SolidPeso molecolare:321.33Cephradine sodium
CAS:Cephradine sodium, a semi-synthetic cephalosporin antibiotic, disrupts bacterial cell wall synthesis, causing lysis.Formula:C16H18N3NaO4SColore e forma:SolidPeso molecolare:371.39Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Formula:C24H27ClN2O3Purezza:99.23%Colore e forma:SolidPeso molecolare:426.94Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formula:C17H20F3N7O2Purezza:97.58% - 98.92%Colore e forma:SolidPeso molecolare:411.38p-Cresyl sulfate potassium
CAS:p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanineFormula:C7H7KO4SPurezza:99.38% - 99.90%Colore e forma:SolidPeso molecolare:226.29BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Formula:C22H26N6O2Purezza:98.11%Colore e forma:SolidPeso molecolare:406.48Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Formula:C23H24ClN3O3Purezza:97.98%Colore e forma:SolidPeso molecolare:425.91ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Formula:C21H31N5O2Purezza:99.56%Colore e forma:SolidPeso molecolare:385.5SR-318
CAS:<p>SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).</p>Formula:C27H33N5O2Purezza:99.74%Colore e forma:SolidPeso molecolare:459.58KO-947
CAS:<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Formula:C21H17N5OPurezza:97.84%Colore e forma:SolidPeso molecolare:355.39Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Formula:C19H20O6Purezza:99.6% - 99.71%Colore e forma:SolidPeso molecolare:344.36Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Formula:C25H17ClF4N6O3SColore e forma:SolidPeso molecolare:592.95CMPD1
CAS:CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).Formula:C22H20FNO2Purezza:99.8%Colore e forma:SolidPeso molecolare:349.4JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Formula:C29H29N7O2Purezza:99.24% - >99.99%Colore e forma:SolidPeso molecolare:507.59ARS-1620
CAS:<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Formula:C21H17ClF2N4O2Purezza:98.86%Colore e forma:SolidPeso molecolare:430.84K-Ras-IN-1
CAS:K-Ras-IN-1 is a K-Ras inhibitor.Formula:C11H13NOSPurezza:98.72%Colore e forma:SolidPeso molecolare:207.29Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Formula:C19H20F3IN2O5SPurezza:99.85% - >99.99%Colore e forma:SolidPeso molecolare:572.34N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formula:C11H15NOPurezza:99.46% - 99.84%Colore e forma:SolidPeso molecolare:177.246H05 (TFA)
CAS:6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Formula:C22H31ClF3N3O4S3Purezza:98.83%Colore e forma:SolidPeso molecolare:590.14JNK-IN-7
CAS:JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Formula:C28H27N7O2Purezza:98.02% - 99.53%Colore e forma:SolidPeso molecolare:493.56SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Formula:C27H27N5O2Purezza:95.42% - 99.06%Colore e forma:SolidPeso molecolare:453.54Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Formula:C15H16ClFIN3O3Colore e forma:SolidPeso molecolare:467.66HPK1-IN-7
CAS:<p>HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).</p>Formula:C24H22N6O4Purezza:99.79%Colore e forma:SolidPeso molecolare:458.47Talmapimod
CAS:Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.Formula:C27H30ClFN4O3Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:513AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Formula:C20H16N6SPurezza:98% - 99.02%Colore e forma:SolidPeso molecolare:372.45Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Formula:C21H22Cl2N4O2Purezza:99.31% - 99.95%Colore e forma:SolidPeso molecolare:433.331-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Formula:C9H10O2SPurezza:99.48%Colore e forma:SolidPeso molecolare:182.24Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Formula:C22H27N7O2SPurezza:99.57% - >99.99%Colore e forma:SolidPeso molecolare:453.56MK2-IN-3
CAS:MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.Formula:C21H16N4OPurezza:99.01%Colore e forma:SolidPeso molecolare:340.38I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFormula:C23H26ClF3N4O2Purezza:99.64% - 99.88%Colore e forma:SolidPeso molecolare:482.92ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formula:C22H25ClFN7O2Purezza:99.55% - 99.76%Colore e forma:SolidPeso molecolare:473.93SM-7368
CAS:<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Formula:C10H5ClN4O5SPurezza:99.64%Colore e forma:SolidPeso molecolare:328.69K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurezza:97.33% - 97.45%Colore e forma:SolidPeso molecolare:513.78BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formula:C25H28N4O2SPurezza:97.16%Colore e forma:SolidPeso molecolare:448.58TAK-715
CAS:<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Formula:C24H21N3OSPurezza:99.83%Colore e forma:SolidPeso molecolare:399.51ML-098
CAS:ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Formula:C19H19NO3Purezza:99.06% - 99.23%Colore e forma:SolidPeso molecolare:309.36KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Formula:C110H186N44O27S2Purezza:98.94%Colore e forma:SolidPeso molecolare:2621.06
