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MAPK

MAPK

Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.

Trovati 894 prodotti di "MAPK"

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  • Inflachromene
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    Inflachromene

    CAS:
    Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.
    Formula:C21H19N3O4
    Purezza:97.36% - 99.88%
    Colore e forma:Solid
    Peso molecolare:377.39

    Ref: TM-T24167

  • HPK1-IN-9
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    HPK1-IN-9

    CAS:
    HPK1-IN-9: Potent MAP4K family kinase inhibitor targeting hematopoietic progenitor cells; potential in HPK1 diseases. (Patent WO2021213317A1)
    Formula:C30H33N7O2
    Colore e forma:Solid
    Peso molecolare:523.63

    Ref: TM-T63670

  • ERK1/2 inhibitor 8
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    ERK1/2 inhibitor 8

    CAS:
    ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).
    Formula:C23H20ClN7O2S
    Colore e forma:Solid
    Peso molecolare:493.97

    Ref: TM-T63331

  • Cobimetinib racemate
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    Cobimetinib racemate

    CAS:
    Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated
    Formula:C21H21F3IN3O2
    Purezza:98.00% - 99.71%
    Colore e forma:Solid
    Peso molecolare:531.31

    Ref: TM-T22677

  • Deltasonamide 1
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    Deltasonamide 1

    CAS:
    Deltasonamide is a potent and selective inhibitor of PDE6δ‐KRas.
    Formula:C30H39ClN6O4S2
    Colore e forma:Solid
    Peso molecolare:647.25

    Ref: TM-T23976

  • (aS)-PH-797804
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    (aS)-PH-797804

    CAS:
    (aS)-PH-797804 is a selective inhibitor of p38 MAPK, demonstrating inhibitory concentration (IC50) values of 26 nM for p38α and 102 nM for p38β. This compound exhibits anti-inflammatory activity [1] [2].
    Formula:C22H19BrF2N2O3
    Colore e forma:Solid
    Peso molecolare:477.3

    Ref: TM-T84894

  • KRAS G12C inhibitor 51
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    KRAS G12C inhibitor 51

    CAS:
    KRAS G12C inhibitor 51 is a KRAS G12C inhibitor.
    Formula:C33H35FN6O3
    Colore e forma:Solid
    Peso molecolare:582.67

    Ref: TM-T64115

  • L 731734
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    L 731734

    CAS:
    L 731734 is a farnesyltransferase inhibitor.
    Formula:C19H38N4O3S
    Colore e forma:Solid
    Peso molecolare:402.6

    Ref: TM-T24350

  • AMG-548 dihydrochloride (864249-60-5 free base)
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    AMG-548 dihydrochloride (864249-60-5 free base)

    AMG-548 dihydrochloride: oral p38α inhibitor, Ki: 0.5 nM; less so for p38β, Ki: 36 nM; >> p38γ/δ; blocks LPS-induced TNFα, IC50: 3 nM.
    Formula:C29H29Cl2N5O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:534.48

    Ref: TM-T10298L2

  • HPK1-IN-37
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    HPK1-IN-37

    CAS:
    HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1.
    Formula:C27H35N7O4
    Colore e forma:Solid
    Peso molecolare:521.61

    Ref: TM-T79787

  • FGTI-2734 mesylate (1247018-19-4 free base)
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    FGTI-2734 mesylate (1247018-19-4 free base)

    CAS:
    FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.
    Formula:C27H35FN6O5S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:606.73

    Ref: TM-T11282L

  • KRas G12C inhibitor 1
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    KRas G12C inhibitor 1

    CAS:
    KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
    Formula:C31H38N6O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:542.67

    Ref: TM-T11776

  • TNIK&MAP4K4-IN-1
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    TNIK&MAP4K4-IN-1

    CAS:
    TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in human
    Formula:C25H23FN4O3
    Colore e forma:Solid
    Peso molecolare:446.47

    Ref: TM-T79794

  • (R)-BDP9066
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    (R)-BDP9066

    CAS:
    (R)-BDP9066 blocks MRCK to curb cancer cell spread, aiding research on diseases like cancer.
    Formula:C20H24N6
    Colore e forma:Solid
    Peso molecolare:348.44

    Ref: TM-T61182

  • TH-Z827
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    TH-Z827

    CAS:
    <p>TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C).</p>
    Formula:C30H38N6O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:498.66

    Ref: TM-T79092

  • KRAS G12C inhibitor 34
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    KRAS G12C inhibitor 34

    CAS:
    KRAS G12C inhibitor 34 is an inhibitor of KRAS G12C that can be used to study cancer research.
    Formula:C32H32ClN5O3
    Colore e forma:Solid
    Peso molecolare:570.08

    Ref: TM-T64033

  • RPR203494
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    RPR203494

    CAS:
    RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.
    Formula:C26H29FN6O4
    Colore e forma:Solid
    Peso molecolare:508.54

    Ref: TM-T69832

  • TC13172
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    TC13172

    CAS:
    TC13172 is a potent, covalent MLKL inhibitor, selective over RIPK1/RIPK3. It blocks TSZ-induced necroptosis (EC50=2nM) and MLKL oligomerization at 100nM.
    Formula:C17H16N4O5S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:388.4

    Ref: TM-T17010

  • SOS1 agonist-1
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    SOS1 agonist-1

    CAS:
    SOS1 agonist-1 (compound 79) serves as an agonist for the Son of sevenless homologue 1 (SOS1), a crucial guanine nucleotide exchange factor involved in catalyzing the GDP to GTP exchange on RAS proteins, thus regulating RAS activation. By increasing nucleotide exchange on RAS, SOS1 agonists enhance cellular RAS-GTP levels and induce biphasic signaling alterations in ERK1/2 phosphorylation, playing a pivotal role in anti-cancer activity [1].
    Formula:C26H29BrClFN4O2
    Colore e forma:Solid
    Peso molecolare:563.89

    Ref: TM-T84791

  • KRAS G12C inhibitor 5
    Targetmol
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    KRAS G12C inhibitor 5

    CAS:
    KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
    Formula:C32H37N7O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:551.68

    Ref: TM-T11780