MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 892 prodotti di "MAPK"
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Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Formula:C22H21F3N4O4SPurezza:99.98%Colore e forma:SolidPeso molecolare:494.49JNK3 inhibitor-3
CAS:JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formula:C26H25N7O2Purezza:98%Colore e forma:SolidPeso molecolare:467.52MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Formula:C18H22FN3O5SPurezza:98%Colore e forma:SolidPeso molecolare:411.45MEK-IN-6
CAS:MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making itFormula:C18H20FN3O4SPurezza:98%Colore e forma:SolidPeso molecolare:393.43ARS-1323-alkyne
CAS:ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.Formula:C28H27ClF2N6O3Purezza:98.00% - 99%Colore e forma:SolidPeso molecolare:569MS934
CAS:<p>MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.</p>Formula:C52H69F3IN7O6SPurezza:98%Colore e forma:SolidPeso molecolare:1104.11KRAS G12C inhibitor 40
CAS:KRAS G12C inhibitor 40 targets KRAS G12C in cancer research (WO2021129824A1, compound 70).Formula:C34H36ClFN10O2Colore e forma:SolidPeso molecolare:671.17K-Ras G12C-IN-2
CAS:K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.Formula:C21H27ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:418.92FGTI-2734
CAS:<p>FGTI-2734, a dual FT/GGT-1 inhibitor (IC50: 250/520 nM), blocks KRAS membrane binding and curbs KRAS-driven pancreatic cancer.</p>Formula:C26H31FN6O2SPurezza:99.69%Colore e forma:SolidPeso molecolare:510.63ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Formula:C28H32ClFN6O5Colore e forma:SolidPeso molecolare:587.04Ilaprazole sodium hydrate
CAS:Ilaprazole sodium hydrate (IY-81149 sodium hydrate) is a proton pump inhibitor that blocks the transport of HSV particles.Formula:C19H21N4NaO4SPurezza:99.2%Colore e forma:SolidPeso molecolare:424.45CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Formula:C55H87N15O22Purezza:98%Colore e forma:SolidPeso molecolare:1310.37ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Formula:C16H17N5O2Colore e forma:SolidPeso molecolare:311.34FGTI-2734 mesylate (1247018-19-4 free base)
CAS:FGTI-2734 mesylate hinders KRAS, overcoming resistance and targeting pancreatic tumors; inhibits FT and GGT with IC50s of 250 nM, 520 nM.Formula:C27H35FN6O5S2Purezza:98%Colore e forma:SolidPeso molecolare:606.73GNE 220
CAS:GNE-220 is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).Formula:C25H26N8Purezza:98%Colore e forma:SolidPeso molecolare:438.53HPK1-IN-12
CAS:HPK1-IN-12 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.Formula:C25H24FN5O2Colore e forma:SolidPeso molecolare:445.49XRP44X
CAS:XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Formula:C21H21ClN4OPurezza:99.67%Colore e forma:SolidPeso molecolare:380.87GNE 220 hydrochloride
CAS:<p>GNE 220 (hydrochloride) is a potent and selective inhibitor of MAP4K4 (IC50: 7 nM).</p>Formula:C25H27ClN8Colore e forma:SolidPeso molecolare:474.99SOS1/KRAS-IN-1
CAS:SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Formula:C24H26F3N5OPurezza:98%Colore e forma:SolidPeso molecolare:457.49HPK1-IN-10
CAS:HPK1-IN-10 inhibits HPK1, a MAP4K kinase from progenitor cells, with potential in treating HPK1 diseases, detailed in patent WO2021213317A1.Formula:C31H34N6O2Colore e forma:SolidPeso molecolare:522.64
